Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development

Lucas J T Kaaij; Robin H van der Weide; René F Ketting; Elzo de Wit

doi:10.1016/j.celrep.2018.06.003

Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development

Lucas J T Kaaij, Robin H van der Weide, René F Ketting^*, Elzo de Wit^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

How do developing zebrafish embryos organize their genome? Kaaij et al. show that, early in development, when there is no transcription, the genome is highly structured; however, when the zygotic genome is activated, this organization is lost. Later in development, the genome again adopts a structured organization.

Original language	English
Pages (from-to)	1-10.e4
Journal	Cell Reports
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2018.06.003
Publication status	Published - 3 Jul 2018
Externally published	Yes

Keywords

Animals
Chromatin/metabolism
Embryonic Development/genetics
Enhancer Elements, Genetic/genetics
Epigenomics
Genome
Histone Code
Zebrafish/embryology

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10.1016/j.celrep.2018.06.003

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title = "Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development",

abstract = "How do developing zebrafish embryos organize their genome? Kaaij et al. show that, early in development, when there is no transcription, the genome is highly structured; however, when the zygotic genome is activated, this organization is lost. Later in development, the genome again adopts a structured organization.",

keywords = "Animals, Chromatin/metabolism, Embryonic Development/genetics, Enhancer Elements, Genetic/genetics, Epigenomics, Genome, Histone Code, Zebrafish/embryology",

author = "Kaaij, {Lucas J T} and {van der Weide}, {Robin H} and Ketting, {Ren{\'e} F} and {de Wit}, Elzo",

year = "2018",

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AU - Ketting, René F

AU - de Wit, Elzo

PY - 2018/7/3

Y1 - 2018/7/3

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AB - How do developing zebrafish embryos organize their genome? Kaaij et al. show that, early in development, when there is no transcription, the genome is highly structured; however, when the zygotic genome is activated, this organization is lost. Later in development, the genome again adopts a structured organization.

KW - Animals

KW - Chromatin/metabolism

KW - Embryonic Development/genetics

KW - Enhancer Elements, Genetic/genetics

KW - Epigenomics

KW - Genome

KW - Histone Code

KW - Zebrafish/embryology

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JO - Cell Reports

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Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development

Abstract

Keywords

Access to Document

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