Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms

Laura D Wood; N Volkan Adsay; Olca Basturk; Lodewijk A A Brosens; Noriyoshi Fukushima; Seung-Mo Hong; Sung-Joo Kim; Jae W Lee; Claudio Luchini; Michaël Noë; Martha B Pitman; Aldo Scarpa; Aatur D Singhi; Mariko Tanaka; Toru Furukawa

doi:10.1016/j.pan.2023.08.002

Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms

Laura D Wood^*
, N Volkan Adsay
, Olca Basturk
, Lodewijk A A Brosens
, Noriyoshi Fukushima
, Seung-Mo Hong
, Sung-Joo Kim
, Jae W Lee
, Claudio Luchini
, Michaël Noë
, Martha B Pitman
, Aldo Scarpa
, Aatur D Singhi
, Mariko Tanaka
, Toru Furukawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examination of the pancreatectomy specimen is a key component of the clinical care of IPMN patients.

METHODS: Systematic literature reviews were conducted around eight topics of clinical relevance in the examination of pathological specimens in patients undergoing resection of IPMN.

RESULTS: This review provides updated perspectives on morphological subtyping of IPMNs, classification of intraductal oncocytic papillary neoplasms, nomenclature for high-grade dysplasia, assessment of T stage, distinction of carcinoma associated or concomitant with IPMN, role of molecular assessment of IPMN tissue, role of intraoperative assessment by frozen section, and preoperative evaluation of cyst fluid cytology.

CONCLUSIONS: This analysis provides the foundation for data-driven approaches to several challenging issues in the pathology of IPMNs.

Original language	English
Pages (from-to)	878-891
Number of pages	14
Journal	Pancreatology
Volume	23
Issue number	7
Early online date	11 Aug 2023
DOIs	https://doi.org/10.1016/j.pan.2023.08.002
Publication status	Published - Nov 2023

Access to Document

10.1016/j.pan.2023.08.002

Cite this

Wood, L. D., Adsay, N. V., Basturk, O., Brosens, L. A. A., Fukushima, N., Hong, S.-M., Kim, S.-J., Lee, J. W., Luchini, C., Noë, M., Pitman, M. B., Scarpa, A., Singhi, A. D., Tanaka, M., & Furukawa, T. (2023). Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms. Pancreatology, 23(7), 878-891. https://doi.org/10.1016/j.pan.2023.08.002

@article{e6243bd009494b61afd71b04f6fe0ac5,

title = "Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms",

abstract = "BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examination of the pancreatectomy specimen is a key component of the clinical care of IPMN patients.METHODS: Systematic literature reviews were conducted around eight topics of clinical relevance in the examination of pathological specimens in patients undergoing resection of IPMN.RESULTS: This review provides updated perspectives on morphological subtyping of IPMNs, classification of intraductal oncocytic papillary neoplasms, nomenclature for high-grade dysplasia, assessment of T stage, distinction of carcinoma associated or concomitant with IPMN, role of molecular assessment of IPMN tissue, role of intraoperative assessment by frozen section, and preoperative evaluation of cyst fluid cytology.CONCLUSIONS: This analysis provides the foundation for data-driven approaches to several challenging issues in the pathology of IPMNs.",

author = "Wood, \{Laura D\} and Adsay, \{N Volkan\} and Olca Basturk and Brosens, \{Lodewijk A A\} and Noriyoshi Fukushima and Seung-Mo Hong and Sung-Joo Kim and Lee, \{Jae W\} and Claudio Luchini and Micha{\"e}l No{\"e} and Pitman, \{Martha B\} and Aldo Scarpa and Singhi, \{Aatur D\} and Mariko Tanaka and Toru Furukawa",

note = "Funding Information: We thank Katie Lobner (Welch Medical Library, Johns Hopkins University School of Medicine) for assistance with literature search. Dr. Wood acknowledges funding support from the Sol Goldman Pancreatic Cancer Research Center and the IPMN Global Foundation. Dr. Furukawa acknowledges funding support from Japan Society for the Promotion of Science KAKENHI Grant Number JP22H02839. The authors report no conflicts of interest. Funding Information: We thank Katie Lobner (Welch Medical Library, Johns Hopkins University School of Medicine) for assistance with literature search. Dr. Wood acknowledges funding support from the Sol Goldman Pancreatic Cancer Research Center and the IPMN Global Foundation. Dr. Furukawa acknowledges funding support from Japan Society for the Promotion of Science KAKENHI Grant Number JP22H02839 . The authors report no conflicts of interest. Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = nov,

doi = "10.1016/j.pan.2023.08.002",

language = "English",

volume = "23",

pages = "878--891",

journal = "Pancreatology",

issn = "1424-3903",

publisher = "Elsevier",

number = "7",

}

TY - JOUR

T1 - Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms

AU - Wood, Laura D

AU - Adsay, N Volkan

AU - Basturk, Olca

AU - Brosens, Lodewijk A A

AU - Fukushima, Noriyoshi

AU - Hong, Seung-Mo

AU - Kim, Sung-Joo

AU - Lee, Jae W

AU - Luchini, Claudio

AU - Noë, Michaël

AU - Pitman, Martha B

AU - Scarpa, Aldo

AU - Singhi, Aatur D

AU - Tanaka, Mariko

AU - Furukawa, Toru

N1 - Funding Information: We thank Katie Lobner (Welch Medical Library, Johns Hopkins University School of Medicine) for assistance with literature search. Dr. Wood acknowledges funding support from the Sol Goldman Pancreatic Cancer Research Center and the IPMN Global Foundation. Dr. Furukawa acknowledges funding support from Japan Society for the Promotion of Science KAKENHI Grant Number JP22H02839. The authors report no conflicts of interest. Funding Information: We thank Katie Lobner (Welch Medical Library, Johns Hopkins University School of Medicine) for assistance with literature search. Dr. Wood acknowledges funding support from the Sol Goldman Pancreatic Cancer Research Center and the IPMN Global Foundation. Dr. Furukawa acknowledges funding support from Japan Society for the Promotion of Science KAKENHI Grant Number JP22H02839 . The authors report no conflicts of interest. Publisher Copyright: © 2023

PY - 2023/11

Y1 - 2023/11

N2 - BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examination of the pancreatectomy specimen is a key component of the clinical care of IPMN patients.METHODS: Systematic literature reviews were conducted around eight topics of clinical relevance in the examination of pathological specimens in patients undergoing resection of IPMN.RESULTS: This review provides updated perspectives on morphological subtyping of IPMNs, classification of intraductal oncocytic papillary neoplasms, nomenclature for high-grade dysplasia, assessment of T stage, distinction of carcinoma associated or concomitant with IPMN, role of molecular assessment of IPMN tissue, role of intraoperative assessment by frozen section, and preoperative evaluation of cyst fluid cytology.CONCLUSIONS: This analysis provides the foundation for data-driven approaches to several challenging issues in the pathology of IPMNs.

AB - BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examination of the pancreatectomy specimen is a key component of the clinical care of IPMN patients.METHODS: Systematic literature reviews were conducted around eight topics of clinical relevance in the examination of pathological specimens in patients undergoing resection of IPMN.RESULTS: This review provides updated perspectives on morphological subtyping of IPMNs, classification of intraductal oncocytic papillary neoplasms, nomenclature for high-grade dysplasia, assessment of T stage, distinction of carcinoma associated or concomitant with IPMN, role of molecular assessment of IPMN tissue, role of intraoperative assessment by frozen section, and preoperative evaluation of cyst fluid cytology.CONCLUSIONS: This analysis provides the foundation for data-driven approaches to several challenging issues in the pathology of IPMNs.

UR - https://www.scopus.com/pages/publications/85168327292

U2 - 10.1016/j.pan.2023.08.002

DO - 10.1016/j.pan.2023.08.002

M3 - Article

C2 - 37604731

SN - 1424-3903

VL - 23

SP - 878

EP - 891

JO - Pancreatology

JF - Pancreatology

IS - 7

ER -

Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms

Abstract

Access to Document

Other files and links

Fingerprint

Cite this