@article{e6243bd009494b61afd71b04f6fe0ac5,
title = "Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms",
abstract = "BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examination of the pancreatectomy specimen is a key component of the clinical care of IPMN patients.METHODS: Systematic literature reviews were conducted around eight topics of clinical relevance in the examination of pathological specimens in patients undergoing resection of IPMN.RESULTS: This review provides updated perspectives on morphological subtyping of IPMNs, classification of intraductal oncocytic papillary neoplasms, nomenclature for high-grade dysplasia, assessment of T stage, distinction of carcinoma associated or concomitant with IPMN, role of molecular assessment of IPMN tissue, role of intraoperative assessment by frozen section, and preoperative evaluation of cyst fluid cytology.CONCLUSIONS: This analysis provides the foundation for data-driven approaches to several challenging issues in the pathology of IPMNs.",
author = "Wood, {Laura D} and Adsay, {N Volkan} and Olca Basturk and Brosens, {Lodewijk A A} and Noriyoshi Fukushima and Seung-Mo Hong and Sung-Joo Kim and Lee, {Jae W} and Claudio Luchini and Micha{\"e}l No{\"e} and Pitman, {Martha B} and Aldo Scarpa and Singhi, {Aatur D} and Mariko Tanaka and Toru Furukawa",
note = "Funding Information: We thank Katie Lobner (Welch Medical Library, Johns Hopkins University School of Medicine) for assistance with literature search. Dr. Wood acknowledges funding support from the Sol Goldman Pancreatic Cancer Research Center and the IPMN Global Foundation. Dr. Furukawa acknowledges funding support from Japan Society for the Promotion of Science KAKENHI Grant Number JP22H02839. The authors report no conflicts of interest. Funding Information: We thank Katie Lobner (Welch Medical Library, Johns Hopkins University School of Medicine) for assistance with literature search. Dr. Wood acknowledges funding support from the Sol Goldman Pancreatic Cancer Research Center and the IPMN Global Foundation. Dr. Furukawa acknowledges funding support from Japan Society for the Promotion of Science KAKENHI Grant Number JP22H02839 . The authors report no conflicts of interest. Publisher Copyright: {\textcopyright} 2023",
year = "2023",
month = nov,
doi = "10.1016/j.pan.2023.08.002",
language = "English",
volume = "23",
pages = "878--891",
journal = "Pancreatology",
issn = "1424-3903",
publisher = "S. Karger AG",
number = "7",
}