Systematic review found that there was moderate evidence that vaccinating healthcare workers prevented pertussis in infants

A. van den Hoogen; J. M. Duijn; L. G.M. Bode; D. C. Vijlbrief; L. de Hooge; H. D.L. Ockhuijsen

doi:10.1111/apa.14124

Systematic review found that there was moderate evidence that vaccinating healthcare workers prevented pertussis in infants

A. van den Hoogen^*, J. M. Duijn, L. G.M. Bode, D. C. Vijlbrief, L. de Hooge, H. D.L. Ockhuijsen

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

This systematic review investigated the effectiveness of vaccinating healthcare workers against pertussis on the occurrence of nosocomial pertussis outbreaks or infections among unprotected infants. We focused on eight studies, with five different study designs, that involved 39,129 healthy adolescents and adults, 115 healthcare workers, 2000 simulated healthcare workers and a simulated population of 200,000 people. Conclusion: There was moderate evidence that tetanus–diphtheria acellular pertussis vaccinations for healthcare workers were effective in preventing pertussis in all age groups and specifically in infants. The results must be interpreted with caution due to the low quality and heterogeneity of the studies.

Original language	English
Pages (from-to)	210-218
Number of pages	9
Journal	Acta Paediatrica
Volume	107
Issue number	2
Early online date	2017
DOIs	https://doi.org/10.1111/apa.14124
Publication status	Published - 1 Feb 2018

Keywords

Adolescent
Adult
Antigens, Bacterial/immunology
Bordetella pertussis/immunology
Diphtheria-Tetanus-acellular Pertussis Vaccines/immunology
Female
Health Personnel
Humans
Immunogenicity, Vaccine
Infant
Male
Vaccination
Whooping Cough/prevention & control

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10.1111/apa.14124

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title = "Systematic review found that there was moderate evidence that vaccinating healthcare workers prevented pertussis in infants",

abstract = "This systematic review investigated the effectiveness of vaccinating healthcare workers against pertussis on the occurrence of nosocomial pertussis outbreaks or infections among unprotected infants. We focused on eight studies, with five different study designs, that involved 39,129 healthy adolescents and adults, 115 healthcare workers, 2000 simulated healthcare workers and a simulated population of 200,000 people. Conclusion: There was moderate evidence that tetanus–diphtheria acellular pertussis vaccinations for healthcare workers were effective in preventing pertussis in all age groups and specifically in infants. The results must be interpreted with caution due to the low quality and heterogeneity of the studies.",

keywords = "Adolescent, Adult, Antigens, Bacterial/immunology, Bordetella pertussis/immunology, Diphtheria-Tetanus-acellular Pertussis Vaccines/immunology, Female, Health Personnel, Humans, Immunogenicity, Vaccine, Infant, Male, Vaccination, Whooping Cough/prevention & control",

author = "{van den Hoogen}, A. and Duijn, {J. M.} and Bode, {L. G.M.} and Vijlbrief, {D. C.} and {de Hooge}, L. and Ockhuijsen, {H. D.L.}",

note = "Funding Information: This research did not receive any specific external funding. Publisher Copyright: {\textcopyright}2017 Foundation Acta P{\ae}diatrica. Published by John Wiley & Sons Ltd Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

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doi = "10.1111/apa.14124",

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AU - van den Hoogen, A.

AU - Duijn, J. M.

AU - Bode, L. G.M.

AU - Vijlbrief, D. C.

AU - de Hooge, L.

AU - Ockhuijsen, H. D.L.

N1 - Funding Information: This research did not receive any specific external funding. Publisher Copyright: ©2017 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2018/2/1

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N2 - This systematic review investigated the effectiveness of vaccinating healthcare workers against pertussis on the occurrence of nosocomial pertussis outbreaks or infections among unprotected infants. We focused on eight studies, with five different study designs, that involved 39,129 healthy adolescents and adults, 115 healthcare workers, 2000 simulated healthcare workers and a simulated population of 200,000 people. Conclusion: There was moderate evidence that tetanus–diphtheria acellular pertussis vaccinations for healthcare workers were effective in preventing pertussis in all age groups and specifically in infants. The results must be interpreted with caution due to the low quality and heterogeneity of the studies.

AB - This systematic review investigated the effectiveness of vaccinating healthcare workers against pertussis on the occurrence of nosocomial pertussis outbreaks or infections among unprotected infants. We focused on eight studies, with five different study designs, that involved 39,129 healthy adolescents and adults, 115 healthcare workers, 2000 simulated healthcare workers and a simulated population of 200,000 people. Conclusion: There was moderate evidence that tetanus–diphtheria acellular pertussis vaccinations for healthcare workers were effective in preventing pertussis in all age groups and specifically in infants. The results must be interpreted with caution due to the low quality and heterogeneity of the studies.

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KW - Adult

KW - Antigens, Bacterial/immunology

KW - Bordetella pertussis/immunology

KW - Diphtheria-Tetanus-acellular Pertussis Vaccines/immunology

KW - Female

KW - Health Personnel

KW - Humans

KW - Immunogenicity, Vaccine

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KW - Male

KW - Vaccination

KW - Whooping Cough/prevention & control

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DO - 10.1111/apa.14124

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SP - 210

EP - 218

JO - Acta Paediatrica

JF - Acta Paediatrica

IS - 2

ER -

Systematic review found that there was moderate evidence that vaccinating healthcare workers prevented pertussis in infants

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