Systematic Review and Meta-Analysis of Liver Resection for Colorectal Metastases in Elderly Patients

Tim van Tuil, Ali A. Dhaif, Wouter W. te Riele, Bert van Ramshorst, Hjalmar C. van Santvoort

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: This systematic review and meta-analysis evaluated the short- and long-term outcomes of liver resection for colorectal liver metastases (CRLM) in elderly patients. Methods: A PubMed, EMBASE, and Cochrane Library search was performed from January 1995 to April 2017, for studies comparing both short- and long-term outcomes in younger and elderly patients undergoing liver resection for CRLM. Results: Eleven studies comparing patients aged <70 years with patients aged >70 years and 4 studies comparing patients aged <75 years with patients aged >75 years were included. Postoperative morbidity was similar in patients aged >70 years (27 vs. 30%; p = 0.35) but higher in patients aged >75 years (21 vs. 32%; p = 0.001). Postoperative mortality was higher in both patients aged >70 years (2 vs. 4%; p = 0.01) and in patients aged >75 years (1 vs. 6%; p = 0.02). Mean 5-year overall survival was lower in patients aged >70 years (40 vs. 32%; p < 0.001) but equal in patients aged >75 years (42 vs. 32%; p = 0.06). Conclusion: Although postoperative morbidity and mortality were increased with higher age, liver resection for CRLM seems justified in selected elderly patients.

Original languageEnglish
Pages (from-to)111-123
Number of pages13
JournalDigestive Surgery
Volume36
Issue number2
DOIs
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • Cancer
  • Liver
  • Surgery

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