Systematic review: accuracy of imaging tests in the diagnosis of recurrent laryngeal carcinoma after radiotherapy

Jolijn Brouwer; Lotty Hooft; Otto S Hoekstra; Ingrid I Riphagen; Jonas A Castelijns; Remco de Bree; C René Leemans

doi:10.1002/hed.20790

Systematic review: accuracy of imaging tests in the diagnosis of recurrent laryngeal carcinoma after radiotherapy

Jolijn Brouwer
, Lotty Hooft
, Otto S Hoekstra
, Ingrid I Riphagen
, Jonas A Castelijns
, Remco de Bree
, C René Leemans

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Diagnosing recurrent laryngeal tumor after radiotherapy is challenging. The most reliable method is direct laryngoscopy under general anesthesia. However, many futile laryngoscopies are performed in disease-free patients. Imaging tests selecting patients for this invasive procedure would be useful. The aim of this systematic review was summarizing the available evidence and determining the diagnostic accuracy of CT, MRI, thallium-201 (201Tl) scintigraphy, and F-18-fluorodeoxyglucose positron emission tomography (18FDG-PET).

METHODS: A systematic review was performed according to the guidelines of the Cochrane Collaboration. Two reviewers scored the articles according to A-, B-, and C-items. Statistical meta-analysis was performed producing summary pooled estimates of sensitivity and specificity.

RESULTS: There were 8 eligible studies on 18FDG-PET. The validity of the 18FDG-PET studies was reasonable; the pooled estimates (95% CI) for sensitivity and specificity were 89% and 74%.

CONCLUSION: The diagnostic accuracy of 18FDG-PET is promising and warrants a randomized trial comparing a strategy based on conventional diagnostic work-up to one based on 18FDG-PET.

Original language	English
Pages (from-to)	889-97
Number of pages	9
Journal	Head & neck
Volume	30
Issue number	7
DOIs	https://doi.org/10.1002/hed.20790
Publication status	Published - Jul 2008

Keywords

Carcinoma, Squamous Cell
Confidence Intervals
Diagnostic Imaging
Female
Fluorodeoxyglucose F18
Humans
Laryngeal Neoplasms
Magnetic Resonance Imaging
Male
Neoplasm Recurrence, Local
Observer Variation
Positron-Emission Tomography
Probability
ROC Curve
Risk Assessment
Sensitivity and Specificity
Tomography, X-Ray Computed
Journal Article
Meta-Analysis
Review

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10.1002/hed.20790

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title = "Systematic review: accuracy of imaging tests in the diagnosis of recurrent laryngeal carcinoma after radiotherapy",

abstract = "BACKGROUND: Diagnosing recurrent laryngeal tumor after radiotherapy is challenging. The most reliable method is direct laryngoscopy under general anesthesia. However, many futile laryngoscopies are performed in disease-free patients. Imaging tests selecting patients for this invasive procedure would be useful. The aim of this systematic review was summarizing the available evidence and determining the diagnostic accuracy of CT, MRI, thallium-201 (201Tl) scintigraphy, and F-18-fluorodeoxyglucose positron emission tomography (18FDG-PET).METHODS: A systematic review was performed according to the guidelines of the Cochrane Collaboration. Two reviewers scored the articles according to A-, B-, and C-items. Statistical meta-analysis was performed producing summary pooled estimates of sensitivity and specificity.RESULTS: There were 8 eligible studies on 18FDG-PET. The validity of the 18FDG-PET studies was reasonable; the pooled estimates (95\% CI) for sensitivity and specificity were 89\% and 74\%.CONCLUSION: The diagnostic accuracy of 18FDG-PET is promising and warrants a randomized trial comparing a strategy based on conventional diagnostic work-up to one based on 18FDG-PET.",

keywords = "Carcinoma, Squamous Cell, Confidence Intervals, Diagnostic Imaging, Female, Fluorodeoxyglucose F18, Humans, Laryngeal Neoplasms, Magnetic Resonance Imaging, Male, Neoplasm Recurrence, Local, Observer Variation, Positron-Emission Tomography, Probability, ROC Curve, Risk Assessment, Sensitivity and Specificity, Tomography, X-Ray Computed, Journal Article, Meta-Analysis, Review",

author = "Jolijn Brouwer and Lotty Hooft and Hoekstra, \{Otto S\} and Riphagen, \{Ingrid I\} and Castelijns, \{Jonas A\} and \{de Bree\}, Remco and Leemans, \{C Ren{\'e}\}",

year = "2008",

month = jul,

doi = "10.1002/hed.20790",

language = "English",

volume = "30",

pages = "889--97",

journal = "Head \& neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

number = "7",

}

TY - JOUR

T1 - Systematic review

T2 - accuracy of imaging tests in the diagnosis of recurrent laryngeal carcinoma after radiotherapy

AU - Brouwer, Jolijn

AU - Hooft, Lotty

AU - Hoekstra, Otto S

AU - Riphagen, Ingrid I

AU - Castelijns, Jonas A

AU - de Bree, Remco

AU - Leemans, C René

PY - 2008/7

Y1 - 2008/7

N2 - BACKGROUND: Diagnosing recurrent laryngeal tumor after radiotherapy is challenging. The most reliable method is direct laryngoscopy under general anesthesia. However, many futile laryngoscopies are performed in disease-free patients. Imaging tests selecting patients for this invasive procedure would be useful. The aim of this systematic review was summarizing the available evidence and determining the diagnostic accuracy of CT, MRI, thallium-201 (201Tl) scintigraphy, and F-18-fluorodeoxyglucose positron emission tomography (18FDG-PET).METHODS: A systematic review was performed according to the guidelines of the Cochrane Collaboration. Two reviewers scored the articles according to A-, B-, and C-items. Statistical meta-analysis was performed producing summary pooled estimates of sensitivity and specificity.RESULTS: There were 8 eligible studies on 18FDG-PET. The validity of the 18FDG-PET studies was reasonable; the pooled estimates (95% CI) for sensitivity and specificity were 89% and 74%.CONCLUSION: The diagnostic accuracy of 18FDG-PET is promising and warrants a randomized trial comparing a strategy based on conventional diagnostic work-up to one based on 18FDG-PET.

AB - BACKGROUND: Diagnosing recurrent laryngeal tumor after radiotherapy is challenging. The most reliable method is direct laryngoscopy under general anesthesia. However, many futile laryngoscopies are performed in disease-free patients. Imaging tests selecting patients for this invasive procedure would be useful. The aim of this systematic review was summarizing the available evidence and determining the diagnostic accuracy of CT, MRI, thallium-201 (201Tl) scintigraphy, and F-18-fluorodeoxyglucose positron emission tomography (18FDG-PET).METHODS: A systematic review was performed according to the guidelines of the Cochrane Collaboration. Two reviewers scored the articles according to A-, B-, and C-items. Statistical meta-analysis was performed producing summary pooled estimates of sensitivity and specificity.RESULTS: There were 8 eligible studies on 18FDG-PET. The validity of the 18FDG-PET studies was reasonable; the pooled estimates (95% CI) for sensitivity and specificity were 89% and 74%.CONCLUSION: The diagnostic accuracy of 18FDG-PET is promising and warrants a randomized trial comparing a strategy based on conventional diagnostic work-up to one based on 18FDG-PET.

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KW - Confidence Intervals

KW - Diagnostic Imaging

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Laryngeal Neoplasms

KW - Magnetic Resonance Imaging

KW - Male

KW - Neoplasm Recurrence, Local

KW - Observer Variation

KW - Positron-Emission Tomography

KW - Probability

KW - ROC Curve

KW - Risk Assessment

KW - Sensitivity and Specificity

KW - Tomography, X-Ray Computed

KW - Journal Article

KW - Meta-Analysis

KW - Review

U2 - 10.1002/hed.20790

DO - 10.1002/hed.20790

M3 - Article

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SN - 1043-3074

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SP - 889

EP - 897

JO - Head & neck

JF - Head & neck

IS - 7

ER -

Systematic review: accuracy of imaging tests in the diagnosis of recurrent laryngeal carcinoma after radiotherapy

Abstract

Keywords

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