TY - JOUR
T1 - SYN-JEM
T2 - A Quantitative Job-Exposure Matrix for Five Lung Carcinogens
AU - Peters, Susan
AU - Vermeulen, Roel
AU - Portengen, Lützen
AU - Olsson, Ann C.
AU - Kendzia, Benjamin
AU - Vincent, Raymond
AU - Savary, Barbara
AU - LavouCrossed Sign, Jcrossed D.Signrôme
AU - Cavallo, Domenico
AU - Cattaneo, Andrea
AU - Mirabelli, Dario
AU - Plato, Nils
AU - Fevotte, Joelle
AU - Pesch, Beate
AU - Brüning, Thomas
AU - Straif, Kurt
AU - Kromhout, Hans
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Objective: The use of measurement data in occupational exposure assessment allows more quantitative analyses of possible exposure-response relations. We describe a quantitative exposure assessment approach for five lung carcinogens (i.e. asbestos, chromium-VI, nickel, polycyclic aromatic hydrocarbons (by its proxy benzo(a)pyrene (BaP)) and respirable crystalline silica). A quantitative job-exposure matrix (JEM) was developed based on statistical modeling of large quantities of personal measurements. Methods: Empirical linear models were developed using personal occupational exposure measurements (n = 102306) from Europe and Canada, as well as auxiliary information like job (industry), year of sampling, region, an a priori exposure rating of each job (none, low, and high exposed), sampling and analytical methods, and sampling duration. The model outcomes were used to create a JEM with a quantitative estimate of the level of exposure by job, year, and region. Results: Decreasing time trends were observed for all agents between the 1970s and 2009, ranging from-1.2% per year for personal BaP and nickel exposures to-10.7% for asbestos (in the time period before an asbestos ban was implemented). Regional differences in exposure concentrations (adjusted for measured jobs, years of measurement, and sampling method and duration) varied by agent, ranging from a factor 3.3 for chromium-VI up to a factor 10.5 for asbestos. Conclusion: We estimated time-, job-, and region-specific exposure levels for four (asbestos, chromium-VI, nickel, and RCS) out of five considered lung carcinogens. Through statistical modeling of large amounts of personal occupational exposure measurement data we were able to derive a quantitative JEM to be used in community-based studies.
AB - Objective: The use of measurement data in occupational exposure assessment allows more quantitative analyses of possible exposure-response relations. We describe a quantitative exposure assessment approach for five lung carcinogens (i.e. asbestos, chromium-VI, nickel, polycyclic aromatic hydrocarbons (by its proxy benzo(a)pyrene (BaP)) and respirable crystalline silica). A quantitative job-exposure matrix (JEM) was developed based on statistical modeling of large quantities of personal measurements. Methods: Empirical linear models were developed using personal occupational exposure measurements (n = 102306) from Europe and Canada, as well as auxiliary information like job (industry), year of sampling, region, an a priori exposure rating of each job (none, low, and high exposed), sampling and analytical methods, and sampling duration. The model outcomes were used to create a JEM with a quantitative estimate of the level of exposure by job, year, and region. Results: Decreasing time trends were observed for all agents between the 1970s and 2009, ranging from-1.2% per year for personal BaP and nickel exposures to-10.7% for asbestos (in the time period before an asbestos ban was implemented). Regional differences in exposure concentrations (adjusted for measured jobs, years of measurement, and sampling method and duration) varied by agent, ranging from a factor 3.3 for chromium-VI up to a factor 10.5 for asbestos. Conclusion: We estimated time-, job-, and region-specific exposure levels for four (asbestos, chromium-VI, nickel, and RCS) out of five considered lung carcinogens. Through statistical modeling of large amounts of personal occupational exposure measurement data we were able to derive a quantitative JEM to be used in community-based studies.
KW - asbestos exposure
KW - chromium
KW - exposure assessment
KW - exposure assessmentmixed models
KW - nickel
KW - polycyclic aromatic hydrocarbons
KW - respirable crystalline silica
KW - retrospective exposure assessment
UR - http://www.scopus.com/inward/record.url?scp=84982953341&partnerID=8YFLogxK
U2 - 10.1093/annhyg/mew034
DO - 10.1093/annhyg/mew034
M3 - Article
C2 - 27286764
AN - SCOPUS:84982953341
SN - 0003-4878
VL - 60
SP - 795
EP - 811
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
IS - 7
ER -