Survival analysis in familial ovarian cancer: a case control study

R P Zweemer; R H Verheijen; J W Coebergh; I J Jacobs; P J van Diest; J J Gille; S Skates; F H Menko; L P Ten Kate; P Kenemans

doi:10.1016/S0301-2115(01)00318-9

Survival analysis in familial ovarian cancer: a case control study

R P Zweemer, R H Verheijen, J W Coebergh, I J Jacobs, P J van Diest, J J Gille, S Skates, F H Menko, L P Ten Kate, P Kenemans

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: familial ovarian cancer patients have been found to differ from sporadic cases, clinically as well as in the molecular make-up of the tumour. Here, a case control study is performed to analyse potential differences in survival.

STUDY DESIGN: 31 families with a strong history of ovarian and/or breast cancer presenting to a family cancer clinic 44 ovarian cancer patients were included. Each patient was matched for age and stage with controls from a cancer registry. Survival rates and the effect of several prognostic factors were analysed.

RESULTS: median survival in the study group differed significantly from controls. A survival benefit for familial cases was maintained up to 5 years after diagnosis. Long-term survival was equally poor in both groups.

CONCLUSION: the difference in survival between familial ovarian cancer cases and matched controls may reflect differences in biological behaviour. This may have important implications for the management and prevention of familial ovarian cancer.

Original language	English
Pages (from-to)	219-223
Number of pages	5
Journal	European Journal of Obstetrics, Gynecology and Reproductive Biology
Volume	98
Issue number	2
DOIs	https://doi.org/10.1016/S0301-2115(01)00318-9
Publication status	Published - 2001

Keywords

BRCA1 Protein
BRCA2 Protein
Case-Control Studies
Female
Germ-Line Mutation
Humans
Middle Aged
Ovarian Neoplasms
Pedigree
Survival Rate

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10.1016/S0301-2115(01)00318-9

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title = "Survival analysis in familial ovarian cancer: a case control study",

abstract = "OBJECTIVE: familial ovarian cancer patients have been found to differ from sporadic cases, clinically as well as in the molecular make-up of the tumour. Here, a case control study is performed to analyse potential differences in survival.STUDY DESIGN: 31 families with a strong history of ovarian and/or breast cancer presenting to a family cancer clinic 44 ovarian cancer patients were included. Each patient was matched for age and stage with controls from a cancer registry. Survival rates and the effect of several prognostic factors were analysed.RESULTS: median survival in the study group differed significantly from controls. A survival benefit for familial cases was maintained up to 5 years after diagnosis. Long-term survival was equally poor in both groups.CONCLUSION: the difference in survival between familial ovarian cancer cases and matched controls may reflect differences in biological behaviour. This may have important implications for the management and prevention of familial ovarian cancer.",

keywords = "BRCA1 Protein, BRCA2 Protein, Case-Control Studies, Female, Germ-Line Mutation, Humans, Middle Aged, Ovarian Neoplasms, Pedigree, Survival Rate",

author = "Zweemer, {R P} and Verheijen, {R H} and Coebergh, {J W} and Jacobs, {I J} and {van Diest}, {P J} and Gille, {J J} and S Skates and Menko, {F H} and {Ten Kate}, {L P} and P Kenemans",

year = "2001",

doi = "10.1016/S0301-2115(01)00318-9",

language = "English",

volume = "98",

pages = "219--223",

journal = "European Journal of Obstetrics, Gynecology and Reproductive Biology",

issn = "0301-2115",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Survival analysis in familial ovarian cancer

T2 - a case control study

AU - Zweemer, R P

AU - Verheijen, R H

AU - Coebergh, J W

AU - Jacobs, I J

AU - van Diest, P J

AU - Gille, J J

AU - Skates, S

AU - Menko, F H

AU - Ten Kate, L P

AU - Kenemans, P

PY - 2001

Y1 - 2001

N2 - OBJECTIVE: familial ovarian cancer patients have been found to differ from sporadic cases, clinically as well as in the molecular make-up of the tumour. Here, a case control study is performed to analyse potential differences in survival.STUDY DESIGN: 31 families with a strong history of ovarian and/or breast cancer presenting to a family cancer clinic 44 ovarian cancer patients were included. Each patient was matched for age and stage with controls from a cancer registry. Survival rates and the effect of several prognostic factors were analysed.RESULTS: median survival in the study group differed significantly from controls. A survival benefit for familial cases was maintained up to 5 years after diagnosis. Long-term survival was equally poor in both groups.CONCLUSION: the difference in survival between familial ovarian cancer cases and matched controls may reflect differences in biological behaviour. This may have important implications for the management and prevention of familial ovarian cancer.

AB - OBJECTIVE: familial ovarian cancer patients have been found to differ from sporadic cases, clinically as well as in the molecular make-up of the tumour. Here, a case control study is performed to analyse potential differences in survival.STUDY DESIGN: 31 families with a strong history of ovarian and/or breast cancer presenting to a family cancer clinic 44 ovarian cancer patients were included. Each patient was matched for age and stage with controls from a cancer registry. Survival rates and the effect of several prognostic factors were analysed.RESULTS: median survival in the study group differed significantly from controls. A survival benefit for familial cases was maintained up to 5 years after diagnosis. Long-term survival was equally poor in both groups.CONCLUSION: the difference in survival between familial ovarian cancer cases and matched controls may reflect differences in biological behaviour. This may have important implications for the management and prevention of familial ovarian cancer.

KW - BRCA1 Protein

KW - BRCA2 Protein

KW - Case-Control Studies

KW - Female

KW - Germ-Line Mutation

KW - Humans

KW - Middle Aged

KW - Ovarian Neoplasms

KW - Pedigree

KW - Survival Rate

U2 - 10.1016/S0301-2115(01)00318-9

DO - 10.1016/S0301-2115(01)00318-9

M3 - Article

C2 - 11574135

SN - 0301-2115

VL - 98

SP - 219

EP - 223

JO - European Journal of Obstetrics, Gynecology and Reproductive Biology

JF - European Journal of Obstetrics, Gynecology and Reproductive Biology

IS - 2

ER -

Survival analysis in familial ovarian cancer: a case control study

Abstract

Keywords

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