TY - JOUR
T1 - Surgical and molecular pathology of pancreatic neoplasms
AU - Hackeng, Wenzel M.
AU - Hruban, Ralph H.
AU - Offerhaus, G. Johan A
AU - Brosens, Lodewijk A A
PY - 2016/6/7
Y1 - 2016/6/7
N2 - BACKGROUND: Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance.MAIN BODY: Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These advances have not only confirmed the traditional histologic classification system, but also opened new doors to early diagnosis and targeted treatment.CONCLUSION: This review discusses the histopathology, genetic and epigenetic alterations and potential treatment targets of the five major malignant pancreatic tumors - pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumor, solid-pseudopapillary neoplasm, acinar cell carcinoma and pancreatoblastoma.
AB - BACKGROUND: Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance.MAIN BODY: Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These advances have not only confirmed the traditional histologic classification system, but also opened new doors to early diagnosis and targeted treatment.CONCLUSION: This review discusses the histopathology, genetic and epigenetic alterations and potential treatment targets of the five major malignant pancreatic tumors - pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumor, solid-pseudopapillary neoplasm, acinar cell carcinoma and pancreatoblastoma.
KW - Acinar cell carcinoma
KW - Genetics
KW - Histology
KW - Methylation
KW - MicroRNA
KW - Pancreas
KW - Pancreatic cancer
KW - Pancreatic neuroendocrine tumor
KW - Sequencing
KW - Solid-pseudopapillary neoplasm
UR - http://www.scopus.com/inward/record.url?scp=84974559944&partnerID=8YFLogxK
U2 - 10.1186/s13000-016-0497-z
DO - 10.1186/s13000-016-0497-z
M3 - Article
C2 - 27267993
AN - SCOPUS:84974559944
SN - 1746-1596
VL - 11
JO - Diagnostic Pathology
JF - Diagnostic Pathology
M1 - 11:47
ER -