SUPPORT FOR ADRENALINE-HYPERTENSION HYPOTHESIS: 18 HOUR PRESSOR EFFECT AFTER 6 HOURS ADRENALINE INFUSION

Peter J. Blankestijn; Joke Tulen; Frans Boomsma; H. J. Ritsema Van Eck; Paul Mulder; Arie J. MAN IN'T VELD; A. H. Van Den Meiracker; Peter Moleman; Frans H.M. Derkx; Steven J. Lamberts; Maarten A.D.H. Schalekamp

doi:10.1016/S0140-6736(88)90585-5

SUPPORT FOR ADRENALINE-HYPERTENSION HYPOTHESIS: 18 HOUR PRESSOR EFFECT AFTER 6 HOURS ADRENALINE INFUSION

Peter J. Blankestijn^*, Joke Tulen, Frans Boomsma, H. J. Ritsema Van Eck, Paul Mulder, Arie J. MAN IN'T VELD, A. H. Van Den Meiracker, Peter Moleman, Frans H.M. Derkx, Steven J. Lamberts, Maarten A.D.H. Schalekamp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

In a double blind, crossover study 6 h infusions of adrenaline (15 ng/kg/min; 1 ng=5·458 pmol), noradrenaline (30 ng/kg/min; 1 ng = 5·911 pmol), and a 5% dextrose solution (5·4 ml/h), were given to ten healthy volunteers in random order 2 weeks apart. By means of intra-arterial ambulatory monitoring the haemodynamic effects were followed for 18 h after the infusions were stopped. Adrenaline, but not noradrenaline, caused a delayed and protracted pressor effect. Over the total postinfusion period systolic and diastolic arterial pressure were 6 (SEM 2)% and 7 (2)%, respectively, higher than after dextrose infusion (ANOVA, p<0·001). Thus, "stress" levels of adrenaline (230 [28] pg/ml) for 6 h cause a delayed and protracted pressor effect. These findings are strong support for the adrenaline-hypertension hypothesis in man.

Original language	English
Pages (from-to)	1386-1389
Number of pages	4
Journal	The Lancet
Volume	332
Issue number	8625
DOIs	https://doi.org/10.1016/S0140-6736(88)90585-5
Publication status	Published - 17 Dec 1988

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Blankestijn, P. J., Tulen, J., Boomsma, F., Ritsema Van Eck, H. J., Mulder, P., MAN IN'T VELD, A. J., Van Den Meiracker, A. H., Moleman, P., Derkx, F. H. M., Lamberts, S. J., & Schalekamp, M. A. D. H. (1988). SUPPORT FOR ADRENALINE-HYPERTENSION HYPOTHESIS: 18 HOUR PRESSOR EFFECT AFTER 6 HOURS ADRENALINE INFUSION. The Lancet, 332(8625), 1386-1389. https://doi.org/10.1016/S0140-6736(88)90585-5

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title = "SUPPORT FOR ADRENALINE-HYPERTENSION HYPOTHESIS: 18 HOUR PRESSOR EFFECT AFTER 6 HOURS ADRENALINE INFUSION",

abstract = "In a double blind, crossover study 6 h infusions of adrenaline (15 ng/kg/min; 1 ng=5·458 pmol), noradrenaline (30 ng/kg/min; 1 ng = 5·911 pmol), and a 5% dextrose solution (5·4 ml/h), were given to ten healthy volunteers in random order 2 weeks apart. By means of intra-arterial ambulatory monitoring the haemodynamic effects were followed for 18 h after the infusions were stopped. Adrenaline, but not noradrenaline, caused a delayed and protracted pressor effect. Over the total postinfusion period systolic and diastolic arterial pressure were 6 (SEM 2)% and 7 (2)%, respectively, higher than after dextrose infusion (ANOVA, p<0·001). Thus, {"}stress{"} levels of adrenaline (230 [28] pg/ml) for 6 h cause a delayed and protracted pressor effect. These findings are strong support for the adrenaline-hypertension hypothesis in man.",

author = "Blankestijn, {Peter J.} and Joke Tulen and Frans Boomsma and {Ritsema Van Eck}, {H. J.} and Paul Mulder and {MAN IN'T VELD}, {Arie J.} and {Van Den Meiracker}, {A. H.} and Peter Moleman and Derkx, {Frans H.M.} and Lamberts, {Steven J.} and Schalekamp, {Maarten A.D.H.}",

year = "1988",

month = dec,

day = "17",

doi = "10.1016/S0140-6736(88)90585-5",

language = "English",

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Blankestijn, PJ, Tulen, J, Boomsma, F, Ritsema Van Eck, HJ, Mulder, P, MAN IN'T VELD, AJ, Van Den Meiracker, AH, Moleman, P, Derkx, FHM, Lamberts, SJ & Schalekamp, MADH 1988, 'SUPPORT FOR ADRENALINE-HYPERTENSION HYPOTHESIS: 18 HOUR PRESSOR EFFECT AFTER 6 HOURS ADRENALINE INFUSION', The Lancet, vol. 332, no. 8625, pp. 1386-1389. https://doi.org/10.1016/S0140-6736(88)90585-5

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AU - Blankestijn, Peter J.

AU - Tulen, Joke

AU - Boomsma, Frans

AU - Ritsema Van Eck, H. J.

AU - Mulder, Paul

AU - MAN IN'T VELD, Arie J.

AU - Van Den Meiracker, A. H.

AU - Moleman, Peter

AU - Derkx, Frans H.M.

AU - Lamberts, Steven J.

AU - Schalekamp, Maarten A.D.H.

PY - 1988/12/17

Y1 - 1988/12/17

N2 - In a double blind, crossover study 6 h infusions of adrenaline (15 ng/kg/min; 1 ng=5·458 pmol), noradrenaline (30 ng/kg/min; 1 ng = 5·911 pmol), and a 5% dextrose solution (5·4 ml/h), were given to ten healthy volunteers in random order 2 weeks apart. By means of intra-arterial ambulatory monitoring the haemodynamic effects were followed for 18 h after the infusions were stopped. Adrenaline, but not noradrenaline, caused a delayed and protracted pressor effect. Over the total postinfusion period systolic and diastolic arterial pressure were 6 (SEM 2)% and 7 (2)%, respectively, higher than after dextrose infusion (ANOVA, p<0·001). Thus, "stress" levels of adrenaline (230 [28] pg/ml) for 6 h cause a delayed and protracted pressor effect. These findings are strong support for the adrenaline-hypertension hypothesis in man.

AB - In a double blind, crossover study 6 h infusions of adrenaline (15 ng/kg/min; 1 ng=5·458 pmol), noradrenaline (30 ng/kg/min; 1 ng = 5·911 pmol), and a 5% dextrose solution (5·4 ml/h), were given to ten healthy volunteers in random order 2 weeks apart. By means of intra-arterial ambulatory monitoring the haemodynamic effects were followed for 18 h after the infusions were stopped. Adrenaline, but not noradrenaline, caused a delayed and protracted pressor effect. Over the total postinfusion period systolic and diastolic arterial pressure were 6 (SEM 2)% and 7 (2)%, respectively, higher than after dextrose infusion (ANOVA, p<0·001). Thus, "stress" levels of adrenaline (230 [28] pg/ml) for 6 h cause a delayed and protracted pressor effect. These findings are strong support for the adrenaline-hypertension hypothesis in man.

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SUPPORT FOR ADRENALINE-HYPERTENSION HYPOTHESIS: 18 HOUR PRESSOR EFFECT AFTER 6 HOURS ADRENALINE INFUSION

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