89Zr-nanocolloidal albumin-based PET/CT lymphoscintigraphy for sentinel node detection in head and neck cancer: Preclinical results

Derrek A. Heuveling; Gerard W.M. Visser; Marian Baclayon; Wouter H. Roos; Gijs J.L. Wuite; Otto S. Hoekstra; C. René Leemans; Remco De Bree; Guus A.M.S. Van Dongen

doi:10.2967/jnumed.111.089557

⁸⁹Zr-nanocolloidal albumin-based PET/CT lymphoscintigraphy for sentinel node detection in head and neck cancer: Preclinical results

Derrek A. Heuveling, Gerard W.M. Visser, Marian Baclayon, Wouter H. Roos, Gijs J.L. Wuite, Otto S. Hoekstra, C. René Leemans, Remco De Bree, Guus A.M.S. Van Dongen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

Abstract

Identifying sentinel nodes near the primary tumor remains a problem in, for example, head and neck cancer because of the limited resolution of current lymphoscintigraphic imaging when using ^99mTc-nanocolloidal albumin. This study describes the development and evaluation of a nanocolloidal albumin-based tracer specifically dedicated for high-resolution PET detection. Methods: ⁸⁹Zr was coupled to nanocolloidal albumin via the bifunctional chelate p-isothiocyanatobenzyldesferrioxamine B. Quality control tests, including particle size measurements, and in vivo biodistribution and imaging experiments in a rabbit lymphogenic metastasis model were performed. Results: Coupling of ⁸⁹Zr to nanocolloidal albumin appeared to be efficient, resulting in a stable product with a radiochemical purity greater than 95%, without affecting the particle size. PET showed distinguished uptake of ⁸⁹Zr-nanocolloidal albumin in the sentinel nodes, with visualization of lymphatic vessels, and with a biodistribution comparable to ^99mTc-nanocolloidal albumin. Conclusion: ⁸⁹Zr- nanocolloidal albumin is a promising tracer for sentinel node detection by PET.

Original language	English
Pages (from-to)	1580-1584
Number of pages	5
Journal	Journal of Nuclear Medicine
Volume	52
Issue number	10
DOIs	https://doi.org/10.2967/jnumed.111.089557
Publication status	Published - 1 Oct 2011

Keywords

Zr
Head and neck cancer
Nanocoll
PET/CT
Sentinel node

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Heuveling, D. A., Visser, G. W. M., Baclayon, M., Roos, W. H., Wuite, G. J. L., Hoekstra, O. S., Leemans, C. R., De Bree, R., & Van Dongen, G. A. M. S. (2011). ⁸⁹Zr-nanocolloidal albumin-based PET/CT lymphoscintigraphy for sentinel node detection in head and neck cancer: Preclinical results. Journal of Nuclear Medicine, 52(10), 1580-1584. https://doi.org/10.2967/jnumed.111.089557

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title = "89Zr-nanocolloidal albumin-based PET/CT lymphoscintigraphy for sentinel node detection in head and neck cancer: Preclinical results",

abstract = "Identifying sentinel nodes near the primary tumor remains a problem in, for example, head and neck cancer because of the limited resolution of current lymphoscintigraphic imaging when using 99mTc-nanocolloidal albumin. This study describes the development and evaluation of a nanocolloidal albumin-based tracer specifically dedicated for high-resolution PET detection. Methods: 89Zr was coupled to nanocolloidal albumin via the bifunctional chelate p-isothiocyanatobenzyldesferrioxamine B. Quality control tests, including particle size measurements, and in vivo biodistribution and imaging experiments in a rabbit lymphogenic metastasis model were performed. Results: Coupling of 89Zr to nanocolloidal albumin appeared to be efficient, resulting in a stable product with a radiochemical purity greater than 95%, without affecting the particle size. PET showed distinguished uptake of 89Zr-nanocolloidal albumin in the sentinel nodes, with visualization of lymphatic vessels, and with a biodistribution comparable to 99mTc-nanocolloidal albumin. Conclusion: 89Zr- nanocolloidal albumin is a promising tracer for sentinel node detection by PET.",

keywords = "Zr, Head and neck cancer, Nanocoll, PET/CT, Sentinel node",

author = "Heuveling, {Derrek A.} and Visser, {Gerard W.M.} and Marian Baclayon and Roos, {Wouter H.} and Wuite, {Gijs J.L.} and Hoekstra, {Otto S.} and Leemans, {C. Ren{\'e}} and {De Bree}, Remco and {Van Dongen}, {Guus A.M.S.}",

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doi = "10.2967/jnumed.111.089557",

language = "English",

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T1 - 89Zr-nanocolloidal albumin-based PET/CT lymphoscintigraphy for sentinel node detection in head and neck cancer

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AU - Heuveling, Derrek A.

AU - Visser, Gerard W.M.

AU - Baclayon, Marian

AU - Roos, Wouter H.

AU - Wuite, Gijs J.L.

AU - Hoekstra, Otto S.

AU - Leemans, C. René

AU - De Bree, Remco

AU - Van Dongen, Guus A.M.S.

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N2 - Identifying sentinel nodes near the primary tumor remains a problem in, for example, head and neck cancer because of the limited resolution of current lymphoscintigraphic imaging when using 99mTc-nanocolloidal albumin. This study describes the development and evaluation of a nanocolloidal albumin-based tracer specifically dedicated for high-resolution PET detection. Methods: 89Zr was coupled to nanocolloidal albumin via the bifunctional chelate p-isothiocyanatobenzyldesferrioxamine B. Quality control tests, including particle size measurements, and in vivo biodistribution and imaging experiments in a rabbit lymphogenic metastasis model were performed. Results: Coupling of 89Zr to nanocolloidal albumin appeared to be efficient, resulting in a stable product with a radiochemical purity greater than 95%, without affecting the particle size. PET showed distinguished uptake of 89Zr-nanocolloidal albumin in the sentinel nodes, with visualization of lymphatic vessels, and with a biodistribution comparable to 99mTc-nanocolloidal albumin. Conclusion: 89Zr- nanocolloidal albumin is a promising tracer for sentinel node detection by PET.

AB - Identifying sentinel nodes near the primary tumor remains a problem in, for example, head and neck cancer because of the limited resolution of current lymphoscintigraphic imaging when using 99mTc-nanocolloidal albumin. This study describes the development and evaluation of a nanocolloidal albumin-based tracer specifically dedicated for high-resolution PET detection. Methods: 89Zr was coupled to nanocolloidal albumin via the bifunctional chelate p-isothiocyanatobenzyldesferrioxamine B. Quality control tests, including particle size measurements, and in vivo biodistribution and imaging experiments in a rabbit lymphogenic metastasis model were performed. Results: Coupling of 89Zr to nanocolloidal albumin appeared to be efficient, resulting in a stable product with a radiochemical purity greater than 95%, without affecting the particle size. PET showed distinguished uptake of 89Zr-nanocolloidal albumin in the sentinel nodes, with visualization of lymphatic vessels, and with a biodistribution comparable to 99mTc-nanocolloidal albumin. Conclusion: 89Zr- nanocolloidal albumin is a promising tracer for sentinel node detection by PET.

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⁸⁹Zr-nanocolloidal albumin-based PET/CT lymphoscintigraphy for sentinel node detection in head and neck cancer: Preclinical results

Abstract

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