Abstract
Magnetic resonance spectroscopy (MRS) allows the non invasive examination of metabolite and ion concentrations in the heart. Total sodium (Na) content potentially allows analysis of myocardial viability, but information on Na content in chronic scar vs. normal myocardial tissue is absent. Thus, the purpose of this work was to study the changes of total myocardial Na content during scar formation after myocardial infarction in a rat model of coronary artery ligation. Rats were subjected to ligation of the left anterior descending coronary artery. At control and 1, 3, 7, 28, and 56 days postoperatively, infarcted tissue was excised, and total Na content was determined with 23Na-MRS and ion chromatography. Na content by 23Na-MRS and ion chromatography was increased to levels between 306 and 160% of control at all time points after MI (n = 6-8 each group, p < 0.01 vs. control). Na content is increased in scar tissue after chronic MI at all time points. Thus, surviving myocardium and scar can be distinguished by total Na content. This information might be used in 23Na-magnetic resonance imaging for the detection of myocardial scar as a clinical tool.
| Translated title of the contribution | 23Na magnetic resonance spectroscopy for the examination of scar formation after myocardiac infarction |
|---|---|
| Original language | German |
| Pages (from-to) | 345-348 |
| Number of pages | 4 |
| Journal | Journal fur Kardiologie |
| Volume | 8 |
| Issue number | 9 |
| Publication status | Published - 1 Oct 2001 |