[18F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmation

Luisa Queiró; Caroline C.C. Hulsker; Leendert H.J. Looijenga; Ronald R. de Krijger; Marijn A. Scheijde-Vermeulen; Pascal J.H. Kusters; Annemieke S. Littooij; Jeanette van Leeuwen; Arthur J.A.T. Braat; Annelies M.C. Mavinkurve-Groothuis

doi:10.1016/j.ejcped.2026.100493

[¹⁸F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmation

Luisa Queiró
, Caroline C.C. Hulsker
, Leendert H.J. Looijenga
, Ronald R. de Krijger
, Marijn A. Scheijde-Vermeulen
, Pascal J.H. Kusters
, Annemieke S. Littooij
, Jeanette van Leeuwen
, Arthur J.A.T. Braat
, Annelies M.C. Mavinkurve-Groothuis^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Gliomatosis is a rare condition mainly associated with ovarian teratomas. It is characterized by the presence of mature glial tissue in extraovarian sites and most frequently found in the peritoneum (gliomatosis peritonei). Gliomatosis in the lymph nodes (nodal gliomatosis) has rarely been reported. We discuss a case of a 4-year-old girl with immature ovarian teratoma with concomitant gliomatosis peritonei and nodal gliomatosis, detected with magnetic resonance imaging (MRI) and Fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography ([¹⁸F]FDG PET/CT) as [¹⁸F]FDG-avid lesions. Histologic examination showed mature well differentiated glial tissue. We aim to highlight the importance of histopathologic assessment of [¹⁸F]FDG positive lesions that may initially appear metastatic.

Original language	English
Article number	100493
Number of pages	3
Journal	EJC Paediatric Oncology
Volume	7
Early online date	18 Feb 2026
DOIs	https://doi.org/10.1016/j.ejcped.2026.100493
Publication status	E-pub ahead of print - 18 Feb 2026

Keywords

Germ cell tumour
Gliomatosis peritonei
Immature teratoma
Nodal gliomatosis
[18 F]FDG-avidity

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[18F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmationFinal published version, 1.29 MBLicence: CC BY-NC

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Queiró, L., Hulsker, C. C. C., Looijenga, L. H. J., de Krijger, R. R., Scheijde-Vermeulen, M. A., Kusters, P. J. H., Littooij, A. S., van Leeuwen, J., Braat, A. J. A. T., & Mavinkurve-Groothuis, A. M. C. (2026). [¹⁸F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmation. EJC Paediatric Oncology, 7, Article 100493. Advance online publication. https://doi.org/10.1016/j.ejcped.2026.100493

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title = "[18F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmation",

abstract = "Gliomatosis is a rare condition mainly associated with ovarian teratomas. It is characterized by the presence of mature glial tissue in extraovarian sites and most frequently found in the peritoneum (gliomatosis peritonei). Gliomatosis in the lymph nodes (nodal gliomatosis) has rarely been reported. We discuss a case of a 4-year-old girl with immature ovarian teratoma with concomitant gliomatosis peritonei and nodal gliomatosis, detected with magnetic resonance imaging (MRI) and Fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography ([18F]FDG PET/CT) as [18F]FDG-avid lesions. Histologic examination showed mature well differentiated glial tissue. We aim to highlight the importance of histopathologic assessment of [18F]FDG positive lesions that may initially appear metastatic.",

keywords = "Germ cell tumour, Gliomatosis peritonei, Immature teratoma, Nodal gliomatosis, [18 F]FDG-avidity",

author = "Luisa Queir{\'o} and Hulsker, \{Caroline C.C.\} and Looijenga, \{Leendert H.J.\} and \{de Krijger\}, \{Ronald R.\} and Scheijde-Vermeulen, \{Marijn A.\} and Kusters, \{Pascal J.H.\} and Littooij, \{Annemieke S.\} and \{van Leeuwen\}, Jeanette and Braat, \{Arthur J.A.T.\} and Mavinkurve-Groothuis, \{Annelies M.C.\}",

note = "Publisher Copyright: {\textcopyright} 2026 The Authors",

year = "2026",

month = feb,

day = "18",

doi = "10.1016/j.ejcped.2026.100493",

language = "English",

volume = "7",

journal = "EJC Paediatric Oncology",

issn = "2772-610X",

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Queiró, L, Hulsker, CCC, Looijenga, LHJ, de Krijger, RR, Scheijde-Vermeulen, MA, Kusters, PJH, Littooij, AS, van Leeuwen, J, Braat, AJAT & Mavinkurve-Groothuis, AMC 2026, '[¹⁸F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmation', EJC Paediatric Oncology, vol. 7, 100493. https://doi.org/10.1016/j.ejcped.2026.100493

TY - JOUR

T1 - [18F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmation

AU - Queiró, Luisa

AU - Hulsker, Caroline C.C.

AU - Looijenga, Leendert H.J.

AU - de Krijger, Ronald R.

AU - Scheijde-Vermeulen, Marijn A.

AU - Kusters, Pascal J.H.

AU - Littooij, Annemieke S.

AU - van Leeuwen, Jeanette

AU - Braat, Arthur J.A.T.

AU - Mavinkurve-Groothuis, Annelies M.C.

PY - 2026/2/18

Y1 - 2026/2/18

N2 - Gliomatosis is a rare condition mainly associated with ovarian teratomas. It is characterized by the presence of mature glial tissue in extraovarian sites and most frequently found in the peritoneum (gliomatosis peritonei). Gliomatosis in the lymph nodes (nodal gliomatosis) has rarely been reported. We discuss a case of a 4-year-old girl with immature ovarian teratoma with concomitant gliomatosis peritonei and nodal gliomatosis, detected with magnetic resonance imaging (MRI) and Fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography ([18F]FDG PET/CT) as [18F]FDG-avid lesions. Histologic examination showed mature well differentiated glial tissue. We aim to highlight the importance of histopathologic assessment of [18F]FDG positive lesions that may initially appear metastatic.

AB - Gliomatosis is a rare condition mainly associated with ovarian teratomas. It is characterized by the presence of mature glial tissue in extraovarian sites and most frequently found in the peritoneum (gliomatosis peritonei). Gliomatosis in the lymph nodes (nodal gliomatosis) has rarely been reported. We discuss a case of a 4-year-old girl with immature ovarian teratoma with concomitant gliomatosis peritonei and nodal gliomatosis, detected with magnetic resonance imaging (MRI) and Fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography ([18F]FDG PET/CT) as [18F]FDG-avid lesions. Histologic examination showed mature well differentiated glial tissue. We aim to highlight the importance of histopathologic assessment of [18F]FDG positive lesions that may initially appear metastatic.

KW - Germ cell tumour

KW - Gliomatosis peritonei

KW - Immature teratoma

KW - Nodal gliomatosis

KW - [18 F]FDG-avidity

UR - https://www.scopus.com/pages/publications/105030481957

U2 - 10.1016/j.ejcped.2026.100493

DO - 10.1016/j.ejcped.2026.100493

M3 - Article

AN - SCOPUS:105030481957

SN - 2772-610X

VL - 7

JO - EJC Paediatric Oncology

JF - EJC Paediatric Oncology

M1 - 100493

ER -

[¹⁸F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmation

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Keywords

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