TY - JOUR
T1 - 18F-FDG PET, genotype-corrected ACE and sIL-2R in newly diagnosed sarcoidosis
AU - Keijsers, Ruth G.
AU - Verzijlbergen, Fred J.
AU - Oyen, Wim J.
AU - Van Den Bosch, Jules M.
AU - Ruven, Henk J.
AU - Van Velzen-Blad, Heleen
AU - Grutters, Jan C.
PY - 2009/7
Y1 - 2009/7
N2 - Purpose: Angiotensin-converting enzyme (ACE) and soluble interleukin-2 receptor (sIL-2R) are serological markers, widely used for determining sarcoidosis activity. 18F-FDG PET has proven to be a sensitive technique in the imaging of sarcoidosis. The aim of this study was to determine sensitivity of 18F-FDG PET, genotype-corrected ACE and sIL-2R in active sarcoidosis as well as their correlation. Methods: This retrospective study included 36 newly diagnosed, symptomatic sarcoidosis patients. ACE and sIL-2R levels were simultaneously obtained within 4 weeks of 18F-FDG PET. ACE was corrected for genotype and expressed as Z-score. 18F-FDG PET was visually evaluated and scored as positive or negative. Maximum and average standardized uptake values (SUVmax and SUVavg) were compared with ACE and sIL-2R. Results: 18F-FDG PET was found positive in 34 of 36 patients (94%). Thirteen pati nts (36%) showed an increased ACE with the highest sensitivity found in patients with the I/I genotype (67%). Seventeen patients (47%) showed an increased sIL-2R. No correlation was found between SUV and ACE or sIL-2R. Increased ACE and sIL-2R correlated with a positive 18F-FDG PET in 12 patients (92%) and 16 patients (94%), respectively. Conclusion: 18F-FDG PET is a very sensitive technique to assess active sarcoidosis, in contrast with ACE and sIL-2R, suggesting a pivotal role for 18F-FDG PET in future sarcoidosis assessment.
AB - Purpose: Angiotensin-converting enzyme (ACE) and soluble interleukin-2 receptor (sIL-2R) are serological markers, widely used for determining sarcoidosis activity. 18F-FDG PET has proven to be a sensitive technique in the imaging of sarcoidosis. The aim of this study was to determine sensitivity of 18F-FDG PET, genotype-corrected ACE and sIL-2R in active sarcoidosis as well as their correlation. Methods: This retrospective study included 36 newly diagnosed, symptomatic sarcoidosis patients. ACE and sIL-2R levels were simultaneously obtained within 4 weeks of 18F-FDG PET. ACE was corrected for genotype and expressed as Z-score. 18F-FDG PET was visually evaluated and scored as positive or negative. Maximum and average standardized uptake values (SUVmax and SUVavg) were compared with ACE and sIL-2R. Results: 18F-FDG PET was found positive in 34 of 36 patients (94%). Thirteen pati nts (36%) showed an increased ACE with the highest sensitivity found in patients with the I/I genotype (67%). Seventeen patients (47%) showed an increased sIL-2R. No correlation was found between SUV and ACE or sIL-2R. Increased ACE and sIL-2R correlated with a positive 18F-FDG PET in 12 patients (92%) and 16 patients (94%), respectively. Conclusion: 18F-FDG PET is a very sensitive technique to assess active sarcoidosis, in contrast with ACE and sIL-2R, suggesting a pivotal role for 18F-FDG PET in future sarcoidosis assessment.
KW - F-FDG PET
KW - Angiotensin-converting enzyme
KW - Sarcoidosis
KW - Soluble interleukin-2 receptor
UR - http://www.scopus.com/inward/record.url?scp=67349276443&partnerID=8YFLogxK
U2 - 10.1007/s00259-009-1097-x
DO - 10.1007/s00259-009-1097-x
M3 - Article
C2 - 19259660
AN - SCOPUS:67349276443
SN - 1619-7070
VL - 36
SP - 1131
EP - 1137
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
IS - 7
ER -