Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region

Anne Debourgogne; Ferry Hagen; Narcisse Elenga; Laurence Long; Denis Blanchet; Vincent Veron; Olivier Lortholary; Bernard Carme; Christine Aznar

doi:10.1016/j.riam.2012.01.008

Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region

Anne Debourgogne
, Ferry Hagen
, Narcisse Elenga
, Laurence Long
, Denis Blanchet
, Vincent Veron
, Olivier Lortholary
, Bernard Carme
, Christine Aznar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Compared to the incidence in adults, cryptococcosis is rare among children. We report a case of neurocryptococcosis due to Cryptococcus gattii in a five-year-old girl without identified risk factors living in French Guiana. Neurological surgery in combination with long-term antifungal treatment with amphotericin B and 5-flucytosine successfully resolved the cryptococcal infection. Subsequent molecular characterization of the Cryptococcus isolate revealed that the infection was caused by a C. gattii genotype AFLP6B/VGIIb strain.

Original language	English
Pages (from-to)	210-3
Number of pages	4
Journal	Revista Iberoamericana de Micologia
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.riam.2012.01.008
Publication status	Published - 2012
Externally published	Yes

Keywords

Central Nervous System Fungal Infections/therapy
Child, Preschool
Cryptococcosis/therapy
Cryptococcus gattii
Female
French Guiana
Humans
Remission Induction

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10.1016/j.riam.2012.01.008

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title = "Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region",

abstract = "Compared to the incidence in adults, cryptococcosis is rare among children. We report a case of neurocryptococcosis due to Cryptococcus gattii in a five-year-old girl without identified risk factors living in French Guiana. Neurological surgery in combination with long-term antifungal treatment with amphotericin B and 5-flucytosine successfully resolved the cryptococcal infection. Subsequent molecular characterization of the Cryptococcus isolate revealed that the infection was caused by a C. gattii genotype AFLP6B/VGIIb strain.",

keywords = "Central Nervous System Fungal Infections/therapy, Child, Preschool, Cryptococcosis/therapy, Cryptococcus gattii, Female, French Guiana, Humans, Remission Induction",

author = "Anne Debourgogne and Ferry Hagen and Narcisse Elenga and Laurence Long and Denis Blanchet and Vincent Veron and Olivier Lortholary and Bernard Carme and Christine Aznar",

year = "2012",

doi = "10.1016/j.riam.2012.01.008",

language = "English",

volume = "29",

pages = "210--3",

journal = "Revista Iberoamericana de Micologia",

issn = "1130-1406",

publisher = "Asociacion Espanola de Micologia",

number = "4",

}

TY - JOUR

T1 - Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region

AU - Debourgogne, Anne

AU - Hagen, Ferry

AU - Elenga, Narcisse

AU - Long, Laurence

AU - Blanchet, Denis

AU - Veron, Vincent

AU - Lortholary, Olivier

AU - Carme, Bernard

AU - Aznar, Christine

PY - 2012

Y1 - 2012

N2 - Compared to the incidence in adults, cryptococcosis is rare among children. We report a case of neurocryptococcosis due to Cryptococcus gattii in a five-year-old girl without identified risk factors living in French Guiana. Neurological surgery in combination with long-term antifungal treatment with amphotericin B and 5-flucytosine successfully resolved the cryptococcal infection. Subsequent molecular characterization of the Cryptococcus isolate revealed that the infection was caused by a C. gattii genotype AFLP6B/VGIIb strain.

AB - Compared to the incidence in adults, cryptococcosis is rare among children. We report a case of neurocryptococcosis due to Cryptococcus gattii in a five-year-old girl without identified risk factors living in French Guiana. Neurological surgery in combination with long-term antifungal treatment with amphotericin B and 5-flucytosine successfully resolved the cryptococcal infection. Subsequent molecular characterization of the Cryptococcus isolate revealed that the infection was caused by a C. gattii genotype AFLP6B/VGIIb strain.

KW - Central Nervous System Fungal Infections/therapy

KW - Child, Preschool

KW - Cryptococcosis/therapy

KW - Cryptococcus gattii

KW - Female

KW - French Guiana

KW - Humans

KW - Remission Induction

U2 - 10.1016/j.riam.2012.01.008

DO - 10.1016/j.riam.2012.01.008

M3 - Article

C2 - 22366716

SN - 1130-1406

VL - 29

SP - 210

EP - 213

JO - Revista Iberoamericana de Micologia

JF - Revista Iberoamericana de Micologia

IS - 4

ER -

Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region

Abstract

Keywords

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