Successful treatment of an advanced interstitial pregnancy by sequential systemic and local administration of methotrexate

A. Hoek; F. J. Broekmans; R. H.M. Verheijen; R. Schats

doi:10.1093/oxfordjournals.humrep.a136193

Successful treatment of an advanced interstitial pregnancy by sequential systemic and local administration of methotrexate

A. Hoek^*, F. J. Broekmans, R. H.M. Verheijen, R. Schats

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

A patient is presented with an advanced interstitial pregnancy, diagnosed by transvaginal ultrasound and confirmed by laparoscopy. Amenorrhoea at the time of diagnosis was 57 days. Methotrexate was given systemically (4×50 mg i.m.). Because of persisting viability of the fetus, systemic methotrexate treatment was followed by local instillation of methotrexate into the gestational sac (50 mg). Follow-up revealed rapid human chorionic gonadotrophin regression but slow regression of fetal remnants.

Original language	English
Pages (from-to)	1864-1865
Number of pages	2
Journal	Human Reproduction
Volume	10
Issue number	7
DOIs	https://doi.org/10.1093/oxfordjournals.humrep.a136193
Publication status	Published - 1 Jan 1995
Externally published	Yes

Keywords

Ectopic pregnancy
HCG serum concentration
Interstitial pregnancy
Methotrexate
Non-surgical treatment

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10.1093/oxfordjournals.humrep.a136193

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title = "Successful treatment of an advanced interstitial pregnancy by sequential systemic and local administration of methotrexate",

abstract = "A patient is presented with an advanced interstitial pregnancy, diagnosed by transvaginal ultrasound and confirmed by laparoscopy. Amenorrhoea at the time of diagnosis was 57 days. Methotrexate was given systemically (4×50 mg i.m.). Because of persisting viability of the fetus, systemic methotrexate treatment was followed by local instillation of methotrexate into the gestational sac (50 mg). Follow-up revealed rapid human chorionic gonadotrophin regression but slow regression of fetal remnants.",

keywords = "Ectopic pregnancy, HCG serum concentration, Interstitial pregnancy, Methotrexate, Non-surgical treatment",

author = "A. Hoek and Broekmans, \{F. J.\} and Verheijen, \{R. H.M.\} and R. Schats",

year = "1995",

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doi = "10.1093/oxfordjournals.humrep.a136193",

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T1 - Successful treatment of an advanced interstitial pregnancy by sequential systemic and local administration of methotrexate

AU - Hoek, A.

AU - Broekmans, F. J.

AU - Verheijen, R. H.M.

AU - Schats, R.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - A patient is presented with an advanced interstitial pregnancy, diagnosed by transvaginal ultrasound and confirmed by laparoscopy. Amenorrhoea at the time of diagnosis was 57 days. Methotrexate was given systemically (4×50 mg i.m.). Because of persisting viability of the fetus, systemic methotrexate treatment was followed by local instillation of methotrexate into the gestational sac (50 mg). Follow-up revealed rapid human chorionic gonadotrophin regression but slow regression of fetal remnants.

AB - A patient is presented with an advanced interstitial pregnancy, diagnosed by transvaginal ultrasound and confirmed by laparoscopy. Amenorrhoea at the time of diagnosis was 57 days. Methotrexate was given systemically (4×50 mg i.m.). Because of persisting viability of the fetus, systemic methotrexate treatment was followed by local instillation of methotrexate into the gestational sac (50 mg). Follow-up revealed rapid human chorionic gonadotrophin regression but slow regression of fetal remnants.

KW - Ectopic pregnancy

KW - HCG serum concentration

KW - Interstitial pregnancy

KW - Methotrexate

KW - Non-surgical treatment

UR - https://www.scopus.com/pages/publications/0029153827

U2 - 10.1093/oxfordjournals.humrep.a136193

DO - 10.1093/oxfordjournals.humrep.a136193

M3 - Article

C2 - 8582999

AN - SCOPUS:0029153827

SN - 0268-1161

VL - 10

SP - 1864

EP - 1865

JO - Human Reproduction

JF - Human Reproduction

IS - 7

ER -

Successful treatment of an advanced interstitial pregnancy by sequential systemic and local administration of methotrexate

Abstract

Keywords

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