TY - JOUR
T1 - Subjective cognitive decline, brain imaging biomarkers, and cognitive functioning in patients with a history of vascular disease
T2 - the SMART-Medea study
AU - Blom, Kim
AU - Koek, Huiberdina L
AU - Zwartbol, Maarten H T
AU - van der Graaf, Yolanda
AU - Kesseler, Lara
AU - Biessels, Geert Jan
AU - Geerlings, Mirjam I
N1 - Funding Information:
Financial support was received by the Alzheimer Nederland—Internationale Stichting Alzheimer Onderzoek (AN-ISAO) (Grant number 12504 ). The SMART study was supported by a grant from the Netherlands Organization for Scientific Research-Medical Sciences (project No. 904-65–095 ). The funding sources had no involvement in writing of this article or the decision to submit it for publication.
Funding Information:
The authors gratefully acknowledge the contribution of the SMART research nurses; R. van Petersen (data manager); B.G.F. Dinther (vascular manager) and the participants of the SMART Study Group: Y. van der Graaf, MD, PhD; D.E. Grobbee, MD, PhD; G.E.H.M. Rutten, MD, PhD, Julius Center for Health Sciences and Primary care; F.L.J. Visseren, MD, PhD, Department of Internal Medicine; G.J. de Borst, MD, PhD, Department of Vascular Surgery; L.J. Kappelle, MD, PhD, Department of Neurology; T. Leiner, MD, PhD, Department of Radiology; P.A. Doevendans, MD, PhD, Department of Cardiology. Financial support was received by the Alzheimer Nederland—Internationale Stichting Alzheimer Onderzoek (AN-ISAO) (Grant number 12504). The SMART study was supported by a grant from the Netherlands Organization for Scientific Research-Medical Sciences (project No. 904-65–095). The funding sources had no involvement in writing of this article or the decision to submit it for publication.
Publisher Copyright:
© 2019 The Authors
PY - 2019/12
Y1 - 2019/12
N2 - We estimated associations of subjective cognitive decline (SCD) with neuroimaging markers of dementia and cognitive functioning in patients with a history of vascular disease without objective cognitive impairment. Within the Second Manifestations of ARTerial disease-Memory, depression and aging study, 599 patients (62 ± 9 years) had 1.5 T brain magnetic resonance imaging and cognitive testing at the baseline and after 8 years of follow-up. Using multiple regression analyses, we estimated cross-sectional and longitudinal associations of SCD according to research criteria with volumes of total brain, hippocampus, white matter hyperintensities, and presence of lacunes and with memory, executive functioning, information processing speed, and working memory. SCD was associated with increased risk of lacunes at the baseline (relative risk = 1.48, 95% confidence interval: 1.03; 2.12) but not during follow-up. No significant associations with volumes of white matter hyperintensities, total brain, or hippocampus were observed. SCD was cross-sectionally associated with poorer executive functioning and speed but not during follow-up. More prospective studies are needed to further elucidate the relationship between SCD, brain imaging markers, and cognitive decline and the role of SCD in the preclinical stage of Alzheimer's disease.
AB - We estimated associations of subjective cognitive decline (SCD) with neuroimaging markers of dementia and cognitive functioning in patients with a history of vascular disease without objective cognitive impairment. Within the Second Manifestations of ARTerial disease-Memory, depression and aging study, 599 patients (62 ± 9 years) had 1.5 T brain magnetic resonance imaging and cognitive testing at the baseline and after 8 years of follow-up. Using multiple regression analyses, we estimated cross-sectional and longitudinal associations of SCD according to research criteria with volumes of total brain, hippocampus, white matter hyperintensities, and presence of lacunes and with memory, executive functioning, information processing speed, and working memory. SCD was associated with increased risk of lacunes at the baseline (relative risk = 1.48, 95% confidence interval: 1.03; 2.12) but not during follow-up. No significant associations with volumes of white matter hyperintensities, total brain, or hippocampus were observed. SCD was cross-sectionally associated with poorer executive functioning and speed but not during follow-up. More prospective studies are needed to further elucidate the relationship between SCD, brain imaging markers, and cognitive decline and the role of SCD in the preclinical stage of Alzheimer's disease.
KW - Brain volume
KW - Cognition
KW - Hippocampal volume
KW - Lacunes of presumed vascular origin
KW - Subjective cognitive decline
KW - White matter hyperintensities
UR - https://www.scopus.com/pages/publications/85071569235
U2 - 10.1016/j.neurobiolaging.2019.07.011
DO - 10.1016/j.neurobiolaging.2019.07.011
M3 - Article
C2 - 31479862
SN - 0197-4580
VL - 84
SP - 33
EP - 40
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -