Study design for the identification of loci affecting human longevity

B. T. Heijmans; C. Kluft; M. L. Bots; A. M. Lagaay; A. Brand; D. E. Grobbee; D. L. Knook; P. E. Slagboom

doi:10.1016/S0268-9499(96)80038-5

Study design for the identification of loci affecting human longevity

B. T. Heijmans, C. Kluft, M. L. Bots, A. M. Lagaay, A. Brand, D. E. Grobbee, D. L. Knook, P. E. Slagboom^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The genetic component of human longevity is estimated at 30%. Which genes are involved in determining human longevity, however, is largely unknown. Genes that may affect human survival are susceptibility loci for major age related pathologies. Many studies are being performed to identify such loci for cardiovascular disease, dementia and diabetes. In order to establish how these loci relate to survival, we have initiated a genetic association study in populations of the oldest old. On the basis of the study design optimised approaches to identify loci affecting human longevity are discussed.

Original language	English
Pages (from-to)	19-20
Number of pages	2
Journal	Fibrinolysis
Volume	10
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/S0268-9499(96)80038-5
Publication status	Published - 1 Jan 1996

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title = "Study design for the identification of loci affecting human longevity",

abstract = "The genetic component of human longevity is estimated at 30%. Which genes are involved in determining human longevity, however, is largely unknown. Genes that may affect human survival are susceptibility loci for major age related pathologies. Many studies are being performed to identify such loci for cardiovascular disease, dementia and diabetes. In order to establish how these loci relate to survival, we have initiated a genetic association study in populations of the oldest old. On the basis of the study design optimised approaches to identify loci affecting human longevity are discussed.",

author = "Heijmans, {B. T.} and C. Kluft and Bots, {M. L.} and Lagaay, {A. M.} and A. Brand and Grobbee, {D. E.} and Knook, {D. L.} and Slagboom, {P. E.}",

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AU - Kluft, C.

AU - Bots, M. L.

AU - Lagaay, A. M.

AU - Brand, A.

AU - Grobbee, D. E.

AU - Knook, D. L.

AU - Slagboom, P. E.

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AB - The genetic component of human longevity is estimated at 30%. Which genes are involved in determining human longevity, however, is largely unknown. Genes that may affect human survival are susceptibility loci for major age related pathologies. Many studies are being performed to identify such loci for cardiovascular disease, dementia and diabetes. In order to establish how these loci relate to survival, we have initiated a genetic association study in populations of the oldest old. On the basis of the study design optimised approaches to identify loci affecting human longevity are discussed.

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ER -

Study design for the identification of loci affecting human longevity

Abstract

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