Study design for the identification of loci affecting human longevity

B. T. Heijmans, C. Kluft, M. L. Bots, A. M. Lagaay, A. Brand, D. E. Grobbee, D. L. Knook, P. E. Slagboom*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The genetic component of human longevity is estimated at 30%. Which genes are involved in determining human longevity, however, is largely unknown. Genes that may affect human survival are susceptibility loci for major age related pathologies. Many studies are being performed to identify such loci for cardiovascular disease, dementia and diabetes. In order to establish how these loci relate to survival, we have initiated a genetic association study in populations of the oldest old. On the basis of the study design optimised approaches to identify loci affecting human longevity are discussed.

Original languageEnglish
Pages (from-to)19-20
Number of pages2
Issue numberSUPPL. 2
Publication statusPublished - 1 Jan 1996


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