Structure-function analysis of the feline herpesvirus virulence factors gE and gI

J D Mijnes; R J de Groot

Structure-function analysis of the feline herpesvirus virulence factors gE and gI

J D Mijnes
, R J de Groot

Infection & Immunity

Research output: Contribution to journal › Review article › peer-review

Abstract

The biosynthesis and function of the gE-gI complex of feline herpesvirus (FHV) was studied by heterologous expression of the cloned genes in the vaccinia virus-based vTF7-3 expression system and by analysis of FHV recombinants. This work has led to the identification of domains in gI involved in complex formation with gE, and to a model for the disulfide-bonded structure of gI. The effects of mutations in gI on gE-gI-dependent cell-to-cell transmission are discussed.

Original language	English
Pages (from-to)	89-91
Number of pages	3
Journal	Veterinary Microbiology
Volume	69
Issue number	1-2
Publication status	Published - 1 Sept 1999

Keywords

Animals
Cats
Cell Communication
Herpesviridae
Membrane Proteins
Molecular Weight
Structure-Activity Relationship
Viral Envelope Proteins
Journal Article
Review

Cite this

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title = "Structure-function analysis of the feline herpesvirus virulence factors gE and gI",

abstract = "The biosynthesis and function of the gE-gI complex of feline herpesvirus (FHV) was studied by heterologous expression of the cloned genes in the vaccinia virus-based vTF7-3 expression system and by analysis of FHV recombinants. This work has led to the identification of domains in gI involved in complex formation with gE, and to a model for the disulfide-bonded structure of gI. The effects of mutations in gI on gE-gI-dependent cell-to-cell transmission are discussed.",

keywords = "Animals, Cats, Cell Communication, Herpesviridae, Membrane Proteins, Molecular Weight, Structure-Activity Relationship, Viral Envelope Proteins, Journal Article, Review",

author = "Mijnes, \{J D\} and \{de Groot\}, \{R J\}",

year = "1999",

month = sep,

day = "1",

language = "English",

volume = "69",

pages = "89--91",

journal = "Veterinary Microbiology",

issn = "0378-1135",

publisher = "Elsevier",

number = "1-2",

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TY - JOUR

T1 - Structure-function analysis of the feline herpesvirus virulence factors gE and gI

AU - Mijnes, J D

AU - de Groot, R J

PY - 1999/9/1

Y1 - 1999/9/1

N2 - The biosynthesis and function of the gE-gI complex of feline herpesvirus (FHV) was studied by heterologous expression of the cloned genes in the vaccinia virus-based vTF7-3 expression system and by analysis of FHV recombinants. This work has led to the identification of domains in gI involved in complex formation with gE, and to a model for the disulfide-bonded structure of gI. The effects of mutations in gI on gE-gI-dependent cell-to-cell transmission are discussed.

AB - The biosynthesis and function of the gE-gI complex of feline herpesvirus (FHV) was studied by heterologous expression of the cloned genes in the vaccinia virus-based vTF7-3 expression system and by analysis of FHV recombinants. This work has led to the identification of domains in gI involved in complex formation with gE, and to a model for the disulfide-bonded structure of gI. The effects of mutations in gI on gE-gI-dependent cell-to-cell transmission are discussed.

KW - Animals

KW - Cats

KW - Cell Communication

KW - Herpesviridae

KW - Membrane Proteins

KW - Molecular Weight

KW - Structure-Activity Relationship

KW - Viral Envelope Proteins

KW - Journal Article

KW - Review

M3 - Review article

C2 - 10515275

SN - 0378-1135

VL - 69

SP - 89

EP - 91

JO - Veterinary Microbiology

JF - Veterinary Microbiology

IS - 1-2

ER -

Structure-function analysis of the feline herpesvirus virulence factors gE and gI

Abstract

Keywords

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