Structure and chromosome location of Smtn, the mouse smoothelin gene

S Rensen; G Merkx; P Doevendans; A Geurts Van Kessel; G van Eys

doi:15619

Structure and chromosome location of Smtn, the mouse smoothelin gene

S Rensen, G Merkx, P Doevendans, A Geurts Van Kessel, G van Eys

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Smoothelins are cytoskeleton-associated proteins that are found in contractile smooth muscle. Two isoforms have been identified: smoothelin-A, expressed in visceral tissues and smoothelin-B, found in vascular tissues. The mouse smoothelin gene (Smtn) was isolated and characterized. It was assigned to chromosome 11 band A2-A3 by fluorescence in situ hybridization. The gene consists of 20 exons and spans 23 kb. Its structure is conserved between mouse and human. The proximal promoter of both smoothelin-A and smoothelin-B contains several transcription factor-binding sites but lacks a consensus TATA box.

Original language	English
Pages (from-to)	225-9
Number of pages	5
Journal	Cytogenetics and Cell Genetics
Volume	89
Issue number	3-4
DOIs	https://doi.org/15619
Publication status	Published - 2000

Keywords

Animals
Base Sequence
Chromosome Mapping
Cloning, Molecular
Cytoskeletal Proteins
DNA
Exons
Genes
In Situ Hybridization, Fluorescence
Introns
Mice
Molecular Sequence Data
Muscle Proteins
Promoter Regions, Genetic
Sequence Alignment
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid

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15619

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title = "Structure and chromosome location of Smtn, the mouse smoothelin gene",

abstract = "Smoothelins are cytoskeleton-associated proteins that are found in contractile smooth muscle. Two isoforms have been identified: smoothelin-A, expressed in visceral tissues and smoothelin-B, found in vascular tissues. The mouse smoothelin gene (Smtn) was isolated and characterized. It was assigned to chromosome 11 band A2-A3 by fluorescence in situ hybridization. The gene consists of 20 exons and spans 23 kb. Its structure is conserved between mouse and human. The proximal promoter of both smoothelin-A and smoothelin-B contains several transcription factor-binding sites but lacks a consensus TATA box.",

keywords = "Animals, Base Sequence, Chromosome Mapping, Cloning, Molecular, Cytoskeletal Proteins, DNA, Exons, Genes, In Situ Hybridization, Fluorescence, Introns, Mice, Molecular Sequence Data, Muscle Proteins, Promoter Regions, Genetic, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Nucleic Acid",

author = "S Rensen and G Merkx and P Doevendans and \{Geurts Van Kessel\}, A and \{van Eys\}, G",

year = "2000",

doi = "15619",

language = "English",

volume = "89",

pages = "225--9",

journal = "Cytogenetics and Cell Genetics",

issn = "0301-0171",

publisher = "S. Karger AG",

number = "3-4",

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TY - JOUR

T1 - Structure and chromosome location of Smtn, the mouse smoothelin gene

AU - Rensen, S

AU - Merkx, G

AU - Doevendans, P

AU - Geurts Van Kessel, A

AU - van Eys, G

PY - 2000

Y1 - 2000

N2 - Smoothelins are cytoskeleton-associated proteins that are found in contractile smooth muscle. Two isoforms have been identified: smoothelin-A, expressed in visceral tissues and smoothelin-B, found in vascular tissues. The mouse smoothelin gene (Smtn) was isolated and characterized. It was assigned to chromosome 11 band A2-A3 by fluorescence in situ hybridization. The gene consists of 20 exons and spans 23 kb. Its structure is conserved between mouse and human. The proximal promoter of both smoothelin-A and smoothelin-B contains several transcription factor-binding sites but lacks a consensus TATA box.

AB - Smoothelins are cytoskeleton-associated proteins that are found in contractile smooth muscle. Two isoforms have been identified: smoothelin-A, expressed in visceral tissues and smoothelin-B, found in vascular tissues. The mouse smoothelin gene (Smtn) was isolated and characterized. It was assigned to chromosome 11 band A2-A3 by fluorescence in situ hybridization. The gene consists of 20 exons and spans 23 kb. Its structure is conserved between mouse and human. The proximal promoter of both smoothelin-A and smoothelin-B contains several transcription factor-binding sites but lacks a consensus TATA box.

KW - Animals

KW - Base Sequence

KW - Chromosome Mapping

KW - Cloning, Molecular

KW - Cytoskeletal Proteins

KW - DNA

KW - Exons

KW - Genes

KW - In Situ Hybridization, Fluorescence

KW - Introns

KW - Mice

KW - Molecular Sequence Data

KW - Muscle Proteins

KW - Promoter Regions, Genetic

KW - Sequence Alignment

KW - Sequence Analysis, DNA

KW - Sequence Homology, Nucleic Acid

U2 - 15619

DO - 15619

M3 - Article

C2 - 10965129

SN - 0301-0171

VL - 89

SP - 225

EP - 229

JO - Cytogenetics and Cell Genetics

JF - Cytogenetics and Cell Genetics

IS - 3-4

ER -

Structure and chromosome location of Smtn, the mouse smoothelin gene

Abstract

Keywords

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