TY - JOUR
T1 - Structural MRI Differences between Patients with and without First Rank Symptoms
T2 - A Delusion?
AU - Heering, Henriette D.
AU - Koevoets, Godefridus J. C.
AU - Koenders, Laura
AU - Machielsen, Marise W J
AU - Meijer, Carin J.
AU - Kubota, Manabu
AU - de Nijs, Jessica
AU - Cahn, Wiepke
AU - Hulshoff Pol, Hilleke E.
AU - de Haan, Lieuwe
AU - Kahn, Rene S.
AU - van Haren, Neeltje E M
PY - 2015
Y1 - 2015
N2 - OBJECTIVE: It has been suggested that specific psychotic symptom clusters may be explained by patterns of biological abnormalities. The presence of first rank symptoms (FRS) has been associated with cognitive abnormalities, e.g., deficits in self-monitoring or in the experience of agency, suggesting that a specific network of neural abnormalities might underlie FRS. Here, we investigate differences in cortical and subcortical brain volume between patients with and without FRS.METHODS: Three independent patient samples (referred to as A, B, and C) with different mean ages and in different illness stages were included, leading to a total of 348 patients within the schizophrenia-spectrum. All underwent magnetic resonance imaging of the brain. In addition, the presence of FRS was established using a diagnostic interview. Patients with (FRS+, A: n = 63, B: n = 129, and C: n = 96) and without FRS (FRS-, A: n = 35, B: n = 17, and C: n = 8) were compared on global and local cortical volumes as well as subcortical volumes, using a whole brain (cerebrum) approach.RESULTS: Nucleus accumbens volume was significantly smaller in FRS+ as compared with FRS- in sample A (p < 0.005). Furthermore, FRS+ showed a smaller volume of the pars-opercularis relative to FRS- in sample B (p < 0.001). No further significant differences were found in cortical and subcortical volumes between FRS+ and FRS- in either one of the three samples after correction for multiple comparison.CONCLUSION: Brain volume differences between patients with and without FRS are, when present, subtle, and not consistent between three independent samples. Brain abnormalities related to FRS may be too subtle to become visible through structural brain imaging.
AB - OBJECTIVE: It has been suggested that specific psychotic symptom clusters may be explained by patterns of biological abnormalities. The presence of first rank symptoms (FRS) has been associated with cognitive abnormalities, e.g., deficits in self-monitoring or in the experience of agency, suggesting that a specific network of neural abnormalities might underlie FRS. Here, we investigate differences in cortical and subcortical brain volume between patients with and without FRS.METHODS: Three independent patient samples (referred to as A, B, and C) with different mean ages and in different illness stages were included, leading to a total of 348 patients within the schizophrenia-spectrum. All underwent magnetic resonance imaging of the brain. In addition, the presence of FRS was established using a diagnostic interview. Patients with (FRS+, A: n = 63, B: n = 129, and C: n = 96) and without FRS (FRS-, A: n = 35, B: n = 17, and C: n = 8) were compared on global and local cortical volumes as well as subcortical volumes, using a whole brain (cerebrum) approach.RESULTS: Nucleus accumbens volume was significantly smaller in FRS+ as compared with FRS- in sample A (p < 0.005). Furthermore, FRS+ showed a smaller volume of the pars-opercularis relative to FRS- in sample B (p < 0.001). No further significant differences were found in cortical and subcortical volumes between FRS+ and FRS- in either one of the three samples after correction for multiple comparison.CONCLUSION: Brain volume differences between patients with and without FRS are, when present, subtle, and not consistent between three independent samples. Brain abnormalities related to FRS may be too subtle to become visible through structural brain imaging.
KW - Corticalvolumes
KW - First rank symptoms
KW - Schizophrenia
KW - Structural MRI image analysis
KW - Subcortical volume
UR - http://www.scopus.com/inward/record.url?scp=84940100824&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2015.00107
DO - 10.3389/fpsyt.2015.00107
M3 - Article
C2 - 26283974
AN - SCOPUS:84940100824
SN - 1664-0640
VL - 6
JO - Frontiers in Psychiatry [E]
JF - Frontiers in Psychiatry [E]
M1 - 107
ER -