Strategies to overcome antineoplastic drug resistance

GA Cirkel

Research output: ThesisDoctoral thesis 1 (Research UU / Graduation UU)

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Abstract

This thesis focuses on various strategies to deal with cancer drug resistance and improve treatment efficacy.

Technological advances have enabled researchers to gain more insight in the immense molecular complexity of cancer and mechanisms of drug resistance. The ability to measure cancer-related molecular aberrations provides an opportunity to predict response to treatment (enabling personalized cancer medicine). In addition, improved understanding of mechanisms of resistance may lead to new rationales to test drugs or innovative treatment strategies with well-established anticancer drugs.

This thesis describes several aspects of the concept of personalized cancer medicine as well as several innovative strategies to delay drug resistance.
Original languageEnglish
Awarding Institution
  • University Medical Center (UMC) Utrecht
Supervisors/Advisors
  • Voest, EE, Primary supervisor
  • Lolkema, M.P.J.K., Co-supervisor
Award date27 Oct 2016
Publisher
Print ISBNs978-94-6233-412-0
Publication statusPublished - 27 Oct 2016

Keywords

  • personalized cancer treatment
  • drug resistance
  • clinical trials
  • biomarker discovery

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