STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe

Melanie Grehn, Stefano Mandija, Marcin Miszczyk, David Krug, Bartłomiej Tomasik, Kristine E Stickney, Pino Alcantara, Filippo Alongi, Matteo Anselmino, Ricardo Salgado Aranda, Brian V Balgobind, Judit Boda-Heggemann, Leif-Hendrik Boldt, Nicola Bottoni, Jakub Cvek, Olgun Elicin, Gaetano Maria De Ferrari, Rutger J Hassink, Colien Hazelaar, Gerhard HindricksCoen Hurkmans, Cinzia Iotti, Tomasz Jadczyk, Otakar Jiravsky, Raphaël Jumeau, Steen Buus Kristiansen, Mario Levis, Manuel Algara López, Julio Martí-Almor, Felix Mehrhof, Ditte Sloth Møller, Giulio Molon, Alexandre Ouss, Petr Peichl, Jiri Plasek, Pieter G Postema, Aurelio Quesada, Tobias Reichlin, Roberto Rordorf, Boris Rudic, Ardan M Saguner, Rachel M A Ter Bekke, José López Torrecilla, Esther G C Troost, Viviana Vitolo, Nicolaus Andratschke, Katja Zeppenfeld, Slawomir Blamek, Martin Fast, Ludovica de Panfilis, Oliver Blanck, Etienne Pruvot, Joost J C Verhoeff

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Abstract

The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions' experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.

Original languageEnglish
Pages (from-to)1284-1295
Number of pages12
JournalEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Volume25
Issue number4
Early online date6 Mar 2023
DOIs
Publication statusPublished - 15 Apr 2023

Keywords

  • Arrhythmias, Cardiac
  • Catheter Ablation/adverse effects
  • Heart Ventricles
  • Humans
  • Prospective Studies
  • Tachycardia, Ventricular
  • Treatment Outcome
  • Stereotactic body radiotherapy
  • Cardiac arrhythmias
  • Ventricular tachycardia
  • EU Horizon 2020
  • Consortium
  • Stereotactic arrhythmia radioablation

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