Stem cell therapy for ischemic heart disease

Rutger J. Hassink; Joshua D. Dowell; Aart Brutel De la Rivière; Pieter A. Doevendans; Loren J. Field

doi:10.1016/j.molmed.2003.08.002

Stem cell therapy for ischemic heart disease

Rutger J. Hassink^*, Joshua D. Dowell, Aart Brutel De la Rivière, Pieter A. Doevendans, Loren J. Field

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Recent experimental and clinical observations have suggested that cell transplantation could be of therapeutic value for the treatment of heart disease. This approach was based on the idea that transplanted donor cardiomyocytes would integrate with the host myocardium and thereby directly contribute to cardiac function. Surprisingly, the observation that non-cardiomyogenic cells could also improve cardiac function indicates that functional integration of donor cells might not be required to achieve a beneficial effect. More recently, several observations have suggested the presence of a greater than anticipated developmental repertoire in adult-derived stem cells, which, if further validated, would offer unprecedented opportunities for the restoration of cardiac function in diseased hearts. Here, we discuss current issues regarding the potential use of stem cell transplantation for the treatment of ischemic heart disease.

Original language	English
Pages (from-to)	436-441
Number of pages	6
Journal	Trends in molecular medicine
Volume	9
Issue number	10
DOIs	https://doi.org/10.1016/j.molmed.2003.08.002
Publication status	Published - Oct 2003

Keywords

Econometric and Statistical Methods: General
Geneeskunde(GENK)
Bescherming en bevordering van de menselijke gezondheid
Other medical specialities

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10.1016/j.molmed.2003.08.002

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title = "Stem cell therapy for ischemic heart disease",

abstract = "Recent experimental and clinical observations have suggested that cell transplantation could be of therapeutic value for the treatment of heart disease. This approach was based on the idea that transplanted donor cardiomyocytes would integrate with the host myocardium and thereby directly contribute to cardiac function. Surprisingly, the observation that non-cardiomyogenic cells could also improve cardiac function indicates that functional integration of donor cells might not be required to achieve a beneficial effect. More recently, several observations have suggested the presence of a greater than anticipated developmental repertoire in adult-derived stem cells, which, if further validated, would offer unprecedented opportunities for the restoration of cardiac function in diseased hearts. Here, we discuss current issues regarding the potential use of stem cell transplantation for the treatment of ischemic heart disease.",

keywords = "Econometric and Statistical Methods: General, Geneeskunde(GENK), Bescherming en bevordering van de menselijke gezondheid, Other medical specialities",

author = "Hassink, \{Rutger J.\} and Dowell, \{Joshua D.\} and \{De la Rivi{\`e}re\}, \{Aart Brutel\} and Doevendans, \{Pieter A.\} and Field, \{Loren J.\}",

year = "2003",

month = oct,

doi = "10.1016/j.molmed.2003.08.002",

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pages = "436--441",

journal = "Trends in molecular medicine",

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T1 - Stem cell therapy for ischemic heart disease

AU - Hassink, Rutger J.

AU - Dowell, Joshua D.

AU - De la Rivière, Aart Brutel

AU - Doevendans, Pieter A.

AU - Field, Loren J.

PY - 2003/10

Y1 - 2003/10

N2 - Recent experimental and clinical observations have suggested that cell transplantation could be of therapeutic value for the treatment of heart disease. This approach was based on the idea that transplanted donor cardiomyocytes would integrate with the host myocardium and thereby directly contribute to cardiac function. Surprisingly, the observation that non-cardiomyogenic cells could also improve cardiac function indicates that functional integration of donor cells might not be required to achieve a beneficial effect. More recently, several observations have suggested the presence of a greater than anticipated developmental repertoire in adult-derived stem cells, which, if further validated, would offer unprecedented opportunities for the restoration of cardiac function in diseased hearts. Here, we discuss current issues regarding the potential use of stem cell transplantation for the treatment of ischemic heart disease.

AB - Recent experimental and clinical observations have suggested that cell transplantation could be of therapeutic value for the treatment of heart disease. This approach was based on the idea that transplanted donor cardiomyocytes would integrate with the host myocardium and thereby directly contribute to cardiac function. Surprisingly, the observation that non-cardiomyogenic cells could also improve cardiac function indicates that functional integration of donor cells might not be required to achieve a beneficial effect. More recently, several observations have suggested the presence of a greater than anticipated developmental repertoire in adult-derived stem cells, which, if further validated, would offer unprecedented opportunities for the restoration of cardiac function in diseased hearts. Here, we discuss current issues regarding the potential use of stem cell transplantation for the treatment of ischemic heart disease.

KW - Econometric and Statistical Methods: General

KW - Geneeskunde(GENK)

KW - Bescherming en bevordering van de menselijke gezondheid

KW - Other medical specialities

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U2 - 10.1016/j.molmed.2003.08.002

DO - 10.1016/j.molmed.2003.08.002

M3 - Review article

C2 - 14557056

SN - 1471-4914

VL - 9

SP - 436

EP - 441

JO - Trends in molecular medicine

JF - Trends in molecular medicine

IS - 10

ER -

Stem cell therapy for ischemic heart disease

Abstract

Keywords

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