Standardized uptake values in FDG PET/CT for prosthetic heart valve endocarditis: a call for standardization

Asbjørn M. Scholtens; Laurens E Swart; Henryk J Te Kolste; Ricardo P J Budde; Marnix G E H Lam; Hein J Verberne

doi:10.1007/s12350-017-0932-x

Standardized uptake values in FDG PET/CT for prosthetic heart valve endocarditis: a call for standardization

Asbjørn M. Scholtens, Laurens E Swart, Henryk J Te Kolste, Ricardo P J Budde, Marnix G E H Lam, Hein J Verberne

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The significance of and threshold values for the standardized uptake value (SUV) in FDG PET/CT to diagnose prosthetic heart valve (PHV) endocarditis (PVE) are unclear at present.

METHODS: A literature search was performed in the PubMed and EMBASE medical databases, comprising the following terms: (FDG OR *fluorode* OR *fluoro-de*) AND (endocarditis OR prosthetic heart valve OR valve replacement). Studies reporting SUVs correlated to the diagnosis of PVE were selected for analysis.

RESULTS: 8 studies were included, with a total of 330 PHVs assessed. SUVs for PVE varied substantially across studies due to differences in acquisition, reconstruction, and measurement protocols, with median SUVmax values for rejected PVE ranging from 0.5 to 4.9 and for definite PVE ranging from 4.2 to 7.4.

CONCLUSION: Reported SUV values for PVE are not interchangeable between sites, and further standardization of quantification is desirable. To this end, optimal protocols for patient preparation, image acquisition, and reconstruction and measurement methods need to be standardized across centers.

Original language	English
Pages (from-to)	2084-2091
Number of pages	8
Journal	Journal of Nuclear Cardiology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1007/s12350-017-0932-x
Publication status	Published - 2018

Keywords

18F-fluorodeoxyglucose
EARL
computed tomography
endocarditis
positron emission tomography
prosthetic heart valve

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title = "Standardized uptake values in FDG PET/CT for prosthetic heart valve endocarditis: a call for standardization",

abstract = "BACKGROUND: The significance of and threshold values for the standardized uptake value (SUV) in FDG PET/CT to diagnose prosthetic heart valve (PHV) endocarditis (PVE) are unclear at present.METHODS: A literature search was performed in the PubMed and EMBASE medical databases, comprising the following terms: (FDG OR *fluorode* OR *fluoro-de*) AND (endocarditis OR prosthetic heart valve OR valve replacement). Studies reporting SUVs correlated to the diagnosis of PVE were selected for analysis.RESULTS: 8 studies were included, with a total of 330 PHVs assessed. SUVs for PVE varied substantially across studies due to differences in acquisition, reconstruction, and measurement protocols, with median SUVmax values for rejected PVE ranging from 0.5 to 4.9 and for definite PVE ranging from 4.2 to 7.4.CONCLUSION: Reported SUV values for PVE are not interchangeable between sites, and further standardization of quantification is desirable. To this end, optimal protocols for patient preparation, image acquisition, and reconstruction and measurement methods need to be standardized across centers.",

keywords = "18F-fluorodeoxyglucose, EARL, computed tomography, endocarditis, positron emission tomography, prosthetic heart valve",

author = "Scholtens, {Asbj{\o}rn M.} and Swart, {Laurens E} and Kolste, {Henryk J Te} and Budde, {Ricardo P J} and Lam, {Marnix G E H} and Verberne, {Hein J}",

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year = "2018",

doi = "10.1007/s12350-017-0932-x",

language = "English",

volume = "25",

pages = "2084--2091",

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T1 - Standardized uptake values in FDG PET/CT for prosthetic heart valve endocarditis

T2 - a call for standardization

AU - Scholtens, Asbjørn M.

AU - Swart, Laurens E

AU - Kolste, Henryk J Te

AU - Budde, Ricardo P J

AU - Lam, Marnix G E H

AU - Verberne, Hein J

PY - 2018

Y1 - 2018

N2 - BACKGROUND: The significance of and threshold values for the standardized uptake value (SUV) in FDG PET/CT to diagnose prosthetic heart valve (PHV) endocarditis (PVE) are unclear at present.METHODS: A literature search was performed in the PubMed and EMBASE medical databases, comprising the following terms: (FDG OR *fluorode* OR *fluoro-de*) AND (endocarditis OR prosthetic heart valve OR valve replacement). Studies reporting SUVs correlated to the diagnosis of PVE were selected for analysis.RESULTS: 8 studies were included, with a total of 330 PHVs assessed. SUVs for PVE varied substantially across studies due to differences in acquisition, reconstruction, and measurement protocols, with median SUVmax values for rejected PVE ranging from 0.5 to 4.9 and for definite PVE ranging from 4.2 to 7.4.CONCLUSION: Reported SUV values for PVE are not interchangeable between sites, and further standardization of quantification is desirable. To this end, optimal protocols for patient preparation, image acquisition, and reconstruction and measurement methods need to be standardized across centers.

AB - BACKGROUND: The significance of and threshold values for the standardized uptake value (SUV) in FDG PET/CT to diagnose prosthetic heart valve (PHV) endocarditis (PVE) are unclear at present.METHODS: A literature search was performed in the PubMed and EMBASE medical databases, comprising the following terms: (FDG OR *fluorode* OR *fluoro-de*) AND (endocarditis OR prosthetic heart valve OR valve replacement). Studies reporting SUVs correlated to the diagnosis of PVE were selected for analysis.RESULTS: 8 studies were included, with a total of 330 PHVs assessed. SUVs for PVE varied substantially across studies due to differences in acquisition, reconstruction, and measurement protocols, with median SUVmax values for rejected PVE ranging from 0.5 to 4.9 and for definite PVE ranging from 4.2 to 7.4.CONCLUSION: Reported SUV values for PVE are not interchangeable between sites, and further standardization of quantification is desirable. To this end, optimal protocols for patient preparation, image acquisition, and reconstruction and measurement methods need to be standardized across centers.

KW - 18F-fluorodeoxyglucose

KW - EARL

KW - computed tomography

KW - endocarditis

KW - positron emission tomography

KW - prosthetic heart valve

U2 - 10.1007/s12350-017-0932-x

DO - 10.1007/s12350-017-0932-x

M3 - Article

C2 - 28585026

SN - 1071-3581

VL - 25

SP - 2084

EP - 2091

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

IS - 6

ER -

Standardized uptake values in FDG PET/CT for prosthetic heart valve endocarditis: a call for standardization

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