Spatially resolved transcriptomics and beyond

Nicola Crosetto; Magda Bienko; Alexander van Oudenaarden

doi:10.1038/nrg3832

Spatially resolved transcriptomics and beyond

Nicola Crosetto, Magda Bienko, Alexander van Oudenaarden

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Considerable progress in sequencing technologies makes it now possible to study the genomic and transcriptomic landscape of single cells. However, to better understand the complexity of multicellular organisms, we must devise ways to perform high-throughput measurements while preserving spatial information about the tissue context or subcellular localization of analysed nucleic acids. In this Innovation article, we summarize pioneering technologies that enable spatially resolved transcriptomics and discuss how these methods have the potential to extend beyond transcriptomics to encompass spatially resolved genomics, proteomics and possibly other omic disciplines.

Original language	English
Pages (from-to)	57-66
Number of pages	10
Journal	Nature Reviews. Genetics
Volume	16
Issue number	1
DOIs	https://doi.org/10.1038/nrg3832
Publication status	Published - Jan 2015

Keywords

Gene Expression Profiling
High-Throughput Screening Assays
Molecular Imaging
Sequence Analysis
Single-Cell Analysis
Spatial Analysis

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10.1038/nrg3832

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KW - High-Throughput Screening Assays

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KW - Sequence Analysis

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Spatially resolved transcriptomics and beyond

Abstract

Keywords

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