TY - JOUR
T1 - Somatic mutations in the brain
T2 - relationship to aging?
AU - Evans, Dana A.P.
AU - Burbach, Peter
AU - van Leeuwen, Fred W.
PY - 1995/10
Y1 - 1995/10
N2 - Genetic instability is generally thought to underlie the process of aging and is predominantly associated with meiosis and mitosis. This review will discuss DNA damage and repair, somatic mutations and somatic recombination events in non-dividing neurons in relation to aging. In general it can be concluded that mutagenesis operates at high frequency in the brain. Present data do not provide clear evidence for accumulating DNA damage or a change in DNA repair activity in the brain with age. However, a linear age-related increase in frameshift mutations has been shown to occur in vasopressin neurons of the rat, revealing a novel post-mitotic mechanism.
AB - Genetic instability is generally thought to underlie the process of aging and is predominantly associated with meiosis and mitosis. This review will discuss DNA damage and repair, somatic mutations and somatic recombination events in non-dividing neurons in relation to aging. In general it can be concluded that mutagenesis operates at high frequency in the brain. Present data do not provide clear evidence for accumulating DNA damage or a change in DNA repair activity in the brain with age. However, a linear age-related increase in frameshift mutations has been shown to occur in vasopressin neurons of the rat, revealing a novel post-mitotic mechanism.
KW - Brain
KW - DNA damage
KW - DNA repair
KW - Neuron
KW - Recombination
KW - Somatic mutation
KW - Vasopressin
UR - http://www.scopus.com/inward/record.url?scp=0029132996&partnerID=8YFLogxK
U2 - 10.1016/0921-8734(95)00022-X
DO - 10.1016/0921-8734(95)00022-X
M3 - Article
C2 - 7565872
AN - SCOPUS:0029132996
SN - 0921-8734
VL - 338
SP - 173
EP - 182
JO - Mutation Research DNAging
JF - Mutation Research DNAging
IS - 1-6
ER -