Solving a cold case of haemolysis: Back to the basics

R. Bijleveld; J. de Kok; B. van der Zwaag; R. van Wijk; T. Diekman

Solving a cold case of haemolysis: Back to the basics

R. Bijleveld^*, J. de Kok, B. van der Zwaag, R. van Wijk, T. Diekman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Membrane disorders comprise an important group of inherited haemolytic anaemias. Diagnostic work-up starts with examination of the blood smear, followed by osmotic gradient ektacytometry. In special cases DNA analysis is performed to confirm the diagnosis. For this purpose a next-generation sequencing-based method has been developed. The combination of these techniques established the correct diagnosis in a case of haemolytic anaemia of unknown cause.

Original language	English
Pages (from-to)	86-89
Number of pages	4
Journal	Netherlands Journal of Medicine
Volume	73
Issue number	2
Publication status	Published - 2015

Keywords

Blood smear
Hemolytic anemia
Next generation sequencing

Cite this

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title = "Solving a cold case of haemolysis: Back to the basics",

abstract = "Membrane disorders comprise an important group of inherited haemolytic anaemias. Diagnostic work-up starts with examination of the blood smear, followed by osmotic gradient ektacytometry. In special cases DNA analysis is performed to confirm the diagnosis. For this purpose a next-generation sequencing-based method has been developed. The combination of these techniques established the correct diagnosis in a case of haemolytic anaemia of unknown cause.",

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year = "2015",

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T2 - Back to the basics

AU - Bijleveld, R.

AU - de Kok, J.

AU - van der Zwaag, B.

AU - van Wijk, R.

AU - Diekman, T.

PY - 2015

Y1 - 2015

N2 - Membrane disorders comprise an important group of inherited haemolytic anaemias. Diagnostic work-up starts with examination of the blood smear, followed by osmotic gradient ektacytometry. In special cases DNA analysis is performed to confirm the diagnosis. For this purpose a next-generation sequencing-based method has been developed. The combination of these techniques established the correct diagnosis in a case of haemolytic anaemia of unknown cause.

AB - Membrane disorders comprise an important group of inherited haemolytic anaemias. Diagnostic work-up starts with examination of the blood smear, followed by osmotic gradient ektacytometry. In special cases DNA analysis is performed to confirm the diagnosis. For this purpose a next-generation sequencing-based method has been developed. The combination of these techniques established the correct diagnosis in a case of haemolytic anaemia of unknown cause.

KW - Blood smear

KW - Hemolytic anemia

KW - Next generation sequencing

UR - https://www.scopus.com/pages/publications/84924565323

M3 - Article

AN - SCOPUS:84924565323

SN - 0300-2977

VL - 73

SP - 86

EP - 89

JO - Netherlands Journal of Medicine

JF - Netherlands Journal of Medicine

IS - 2

ER -

Solving a cold case of haemolysis: Back to the basics

Abstract

Keywords

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