Soluble CD30 measured after lung transplantation does not predict bronchiolitis obliterans syndrome in a tacrolimus/mycophenolate mofetil-based immunosuppressive regimen

J.M. Kwakkel - van Erp; H.G. Otten; A.W.M. Paantjens; D.A. Kessel; W.G.J. van Ginkel; J.M.M. van den Bosch; E.A. van de Graaf

doi:10.1016/j.healun.2008.06.007

Soluble CD30 measured after lung transplantation does not predict bronchiolitis obliterans syndrome in a tacrolimus/mycophenolate mofetil-based immunosuppressive regimen

J.M. Kwakkel - van Erp
, H.G. Otten
, A.W.M. Paantjens
, D.A. Kessel
, W.G.J. van Ginkel
, J.M.M. van den Bosch
, E.A. van de Graaf

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The purpose of this study was to determine the utility of post-transplant serum soluble CD30 levels as a biomarker for the development of the bronchiolitis obliterans syndrome (BOS) after lung transplantation during a tacrolimus/mycophenolate mofetil-based regimen.

METHODS: Soluble CD30 (sCD30) concentrations were measured prior to transplantation and in 175 samples taken after transplantation in 7 patients developing BOS and 7 non-BOS patients closely matched for age, underlying diseases, follow-up and gender.

RESULTS: High pre-transplant sCD30 levels dropped significantly after lung transplantation, but in the post-transplant samples no differences could be detected between patients developing BOS or not, and no changes were found prior to or during the development of BOS.

CONCLUSIONS: After transplantation, sCD30 levels are consistently suppressed, but BOS is not prevented, indicating that sCD30 cannot be used as a biomarker to predict BOS after transplantation in the regimen employed.

Original language	English
Pages (from-to)	1172-1175
Number of pages	4
Journal	Journal of Heart and Lung Transplantation
Volume	27
Issue number	10
DOIs	https://doi.org/10.1016/j.healun.2008.06.007
Publication status	Published - 2008

Keywords

Adult
Antigens, CD
Biomarkers
Bronchiolitis Obliterans
Emphysema
Female
Graft Survival
Humans
Immunosuppressive Agents
Informed Consent
Ki-1 Antigen
Lung Transplantation
Male
Middle Aged
Mycophenolic Acid
Postoperative Complications
Predictive Value of Tests
Pulmonary Disease, Chronic Obstructive
Tacrolimus
Case Reports
Journal Article

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10.1016/j.healun.2008.06.007

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Kwakkel - van Erp, J. M., Otten, H. G., Paantjens, A. W. M., Kessel, D. A., van Ginkel, W. G. J., van den Bosch, J. M. M., & van de Graaf, E. A. (2008). Soluble CD30 measured after lung transplantation does not predict bronchiolitis obliterans syndrome in a tacrolimus/mycophenolate mofetil-based immunosuppressive regimen. Journal of Heart and Lung Transplantation, 27(10), 1172-1175. https://doi.org/10.1016/j.healun.2008.06.007

@article{2e94e874119e4c7eb63c0b0c678b2405,

title = "Soluble CD30 measured after lung transplantation does not predict bronchiolitis obliterans syndrome in a tacrolimus/mycophenolate mofetil-based immunosuppressive regimen",

abstract = "BACKGROUND: The purpose of this study was to determine the utility of post-transplant serum soluble CD30 levels as a biomarker for the development of the bronchiolitis obliterans syndrome (BOS) after lung transplantation during a tacrolimus/mycophenolate mofetil-based regimen.METHODS: Soluble CD30 (sCD30) concentrations were measured prior to transplantation and in 175 samples taken after transplantation in 7 patients developing BOS and 7 non-BOS patients closely matched for age, underlying diseases, follow-up and gender.RESULTS: High pre-transplant sCD30 levels dropped significantly after lung transplantation, but in the post-transplant samples no differences could be detected between patients developing BOS or not, and no changes were found prior to or during the development of BOS.CONCLUSIONS: After transplantation, sCD30 levels are consistently suppressed, but BOS is not prevented, indicating that sCD30 cannot be used as a biomarker to predict BOS after transplantation in the regimen employed.",

keywords = "Adult, Antigens, CD, Biomarkers, Bronchiolitis Obliterans, Emphysema, Female, Graft Survival, Humans, Immunosuppressive Agents, Informed Consent, Ki-1 Antigen, Lung Transplantation, Male, Middle Aged, Mycophenolic Acid, Postoperative Complications, Predictive Value of Tests, Pulmonary Disease, Chronic Obstructive, Tacrolimus, Case Reports, Journal Article",

author = "\{Kwakkel - van Erp\}, J.M. and H.G. Otten and A.W.M. Paantjens and D.A. Kessel and \{van Ginkel\}, W.G.J. and \{van den Bosch\}, J.M.M. and \{van de Graaf\}, E.A.",

year = "2008",

doi = "10.1016/j.healun.2008.06.007",

language = "English",

volume = "27",

pages = "1172--1175",

journal = "Journal of Heart and Lung Transplantation",

issn = "1053-2498",

publisher = "Elsevier",

number = "10",

}

Kwakkel - van Erp, JM, Otten, HG, Paantjens, AWM, Kessel, DA, van Ginkel, WGJ, van den Bosch, JMM & van de Graaf, EA 2008, 'Soluble CD30 measured after lung transplantation does not predict bronchiolitis obliterans syndrome in a tacrolimus/mycophenolate mofetil-based immunosuppressive regimen', Journal of Heart and Lung Transplantation, vol. 27, no. 10, pp. 1172-1175. https://doi.org/10.1016/j.healun.2008.06.007

Soluble CD30 measured after lung transplantation does not predict bronchiolitis obliterans syndrome in a tacrolimus/mycophenolate mofetil-based immunosuppressive regimen. / Kwakkel - van Erp, J.M.; Otten, H.G.; Paantjens, A.W.M. et al.
In: Journal of Heart and Lung Transplantation, Vol. 27, No. 10, 2008, p. 1172-1175.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Soluble CD30 measured after lung transplantation does not predict bronchiolitis obliterans syndrome in a tacrolimus/mycophenolate mofetil-based immunosuppressive regimen

AU - Kwakkel - van Erp, J.M.

AU - Otten, H.G.

AU - Paantjens, A.W.M.

AU - Kessel, D.A.

AU - van Ginkel, W.G.J.

AU - van den Bosch, J.M.M.

AU - van de Graaf, E.A.

PY - 2008

Y1 - 2008

N2 - BACKGROUND: The purpose of this study was to determine the utility of post-transplant serum soluble CD30 levels as a biomarker for the development of the bronchiolitis obliterans syndrome (BOS) after lung transplantation during a tacrolimus/mycophenolate mofetil-based regimen.METHODS: Soluble CD30 (sCD30) concentrations were measured prior to transplantation and in 175 samples taken after transplantation in 7 patients developing BOS and 7 non-BOS patients closely matched for age, underlying diseases, follow-up and gender.RESULTS: High pre-transplant sCD30 levels dropped significantly after lung transplantation, but in the post-transplant samples no differences could be detected between patients developing BOS or not, and no changes were found prior to or during the development of BOS.CONCLUSIONS: After transplantation, sCD30 levels are consistently suppressed, but BOS is not prevented, indicating that sCD30 cannot be used as a biomarker to predict BOS after transplantation in the regimen employed.

AB - BACKGROUND: The purpose of this study was to determine the utility of post-transplant serum soluble CD30 levels as a biomarker for the development of the bronchiolitis obliterans syndrome (BOS) after lung transplantation during a tacrolimus/mycophenolate mofetil-based regimen.METHODS: Soluble CD30 (sCD30) concentrations were measured prior to transplantation and in 175 samples taken after transplantation in 7 patients developing BOS and 7 non-BOS patients closely matched for age, underlying diseases, follow-up and gender.RESULTS: High pre-transplant sCD30 levels dropped significantly after lung transplantation, but in the post-transplant samples no differences could be detected between patients developing BOS or not, and no changes were found prior to or during the development of BOS.CONCLUSIONS: After transplantation, sCD30 levels are consistently suppressed, but BOS is not prevented, indicating that sCD30 cannot be used as a biomarker to predict BOS after transplantation in the regimen employed.

KW - Adult

KW - Antigens, CD

KW - Biomarkers

KW - Bronchiolitis Obliterans

KW - Emphysema

KW - Female

KW - Graft Survival

KW - Humans

KW - Immunosuppressive Agents

KW - Informed Consent

KW - Ki-1 Antigen

KW - Lung Transplantation

KW - Male

KW - Middle Aged

KW - Mycophenolic Acid

KW - Postoperative Complications

KW - Predictive Value of Tests

KW - Pulmonary Disease, Chronic Obstructive

KW - Tacrolimus

KW - Case Reports

KW - Journal Article

U2 - 10.1016/j.healun.2008.06.007

DO - 10.1016/j.healun.2008.06.007

M3 - Article

C2 - 18926413

SN - 1053-2498

VL - 27

SP - 1172

EP - 1175

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

IS - 10

ER -

Soluble CD30 measured after lung transplantation does not predict bronchiolitis obliterans syndrome in a tacrolimus/mycophenolate mofetil-based immunosuppressive regimen

Abstract

Keywords

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