Sofosbuvir add-on to ribavirin treatment for chronic hepatitis e virus infection in solid organ transplant recipients does not result in sustained virological response

E. M. Van Wezel; J. De Bruijne; K. Damman; M. Bijmolen; A. P. Van Den Berg; E. A.M. Verschuuren; G. A. Ruigrok; A. Riezebos-Brilman; M. Knoester

doi:10.1093/ofid/ofz346

Sofosbuvir add-on to ribavirin treatment for chronic hepatitis e virus infection in solid organ transplant recipients does not result in sustained virological response

E. M. Van Wezel^*, J. De Bruijne, K. Damman, M. Bijmolen, A. P. Van Den Berg, E. A.M. Verschuuren, G. A. Ruigrok, A. Riezebos-Brilman, M. Knoester

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Ribavirin is effective for treating immunocompromised patients with chronic hepatitis E virus infection. However, ribavirin treatment is not always successful. We describe 3 solid organ transplant recipients treated with sofosbuvir and ribavirin after failing ribavirin monotherapy. Complete elimination of hepatitis E virus could not be achieved.

Original language	English
Article number	ofz346
Journal	Open forum infectious diseases
Volume	6
Issue number	8
DOIs	https://doi.org/10.1093/ofid/ofz346
Publication status	Published - 1 Aug 2019

Keywords

chronic hepatitis E
sofosbuvir
solid organ transplant recipients

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10.1093/ofid/ofz346

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Van Wezel, E. M., De Bruijne, J., Damman, K., Bijmolen, M., Van Den Berg, A. P., Verschuuren, E. A. M., Ruigrok, G. A., Riezebos-Brilman, A., & Knoester, M. (2019). Sofosbuvir add-on to ribavirin treatment for chronic hepatitis e virus infection in solid organ transplant recipients does not result in sustained virological response. Open forum infectious diseases, 6(8), Article ofz346. https://doi.org/10.1093/ofid/ofz346

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title = "Sofosbuvir add-on to ribavirin treatment for chronic hepatitis e virus infection in solid organ transplant recipients does not result in sustained virological response",

abstract = "Ribavirin is effective for treating immunocompromised patients with chronic hepatitis E virus infection. However, ribavirin treatment is not always successful. We describe 3 solid organ transplant recipients treated with sofosbuvir and ribavirin after failing ribavirin monotherapy. Complete elimination of hepatitis E virus could not be achieved.",

keywords = "chronic hepatitis E, sofosbuvir, solid organ transplant recipients",

author = "{Van Wezel}, {E. M.} and {De Bruijne}, J. and K. Damman and M. Bijmolen and {Van Den Berg}, {A. P.} and Verschuuren, {E. A.M.} and Ruigrok, {G. A.} and A. Riezebos-Brilman and M. Knoester",

note = "{\textcopyright} The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2019",

month = aug,

day = "1",

doi = "10.1093/ofid/ofz346",

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Van Wezel, EM, De Bruijne, J, Damman, K, Bijmolen, M, Van Den Berg, AP, Verschuuren, EAM, Ruigrok, GA, Riezebos-Brilman, A & Knoester, M 2019, 'Sofosbuvir add-on to ribavirin treatment for chronic hepatitis e virus infection in solid organ transplant recipients does not result in sustained virological response', Open forum infectious diseases, vol. 6, no. 8, ofz346. https://doi.org/10.1093/ofid/ofz346

Sofosbuvir add-on to ribavirin treatment for chronic hepatitis e virus infection in solid organ transplant recipients does not result in sustained virological response. / Van Wezel, E. M.; De Bruijne, J.; Damman, K. et al.
In: Open forum infectious diseases, Vol. 6, No. 8, ofz346, 01.08.2019.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Sofosbuvir add-on to ribavirin treatment for chronic hepatitis e virus infection in solid organ transplant recipients does not result in sustained virological response

AU - Van Wezel, E. M.

AU - De Bruijne, J.

AU - Damman, K.

AU - Bijmolen, M.

AU - Van Den Berg, A. P.

AU - Verschuuren, E. A.M.

AU - Ruigrok, G. A.

AU - Riezebos-Brilman, A.

AU - Knoester, M.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Ribavirin is effective for treating immunocompromised patients with chronic hepatitis E virus infection. However, ribavirin treatment is not always successful. We describe 3 solid organ transplant recipients treated with sofosbuvir and ribavirin after failing ribavirin monotherapy. Complete elimination of hepatitis E virus could not be achieved.

AB - Ribavirin is effective for treating immunocompromised patients with chronic hepatitis E virus infection. However, ribavirin treatment is not always successful. We describe 3 solid organ transplant recipients treated with sofosbuvir and ribavirin after failing ribavirin monotherapy. Complete elimination of hepatitis E virus could not be achieved.

KW - chronic hepatitis E

KW - sofosbuvir

KW - solid organ transplant recipients

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U2 - 10.1093/ofid/ofz346

DO - 10.1093/ofid/ofz346

M3 - Article

C2 - 31404927

AN - SCOPUS:85071175454

SN - 2328-8957

VL - 6

JO - Open forum infectious diseases

JF - Open forum infectious diseases

IS - 8

M1 - ofz346

ER -

Sofosbuvir add-on to ribavirin treatment for chronic hepatitis e virus infection in solid organ transplant recipients does not result in sustained virological response

Abstract

Keywords

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