Sodium-potassium pump assessment by submaximal electrical nerve stimulation

Steven Hageman; Maria O Kovalchuk; Boudewijn T H M Sleutjes; Leonard J van Schelven; Leonard H van den Berg; Hessel Franssen

doi:10.1016/j.clinph.2018.01.016

Sodium-potassium pump assessment by submaximal electrical nerve stimulation

Steven Hageman
, Maria O Kovalchuk
, Boudewijn T H M Sleutjes
, Leonard J van Schelven
, Leonard H van den Berg
, Hessel Franssen

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: Sodium-potassium pump dysfunction in peripheral nerve is usually assessed by determining axonal hyperpolarization following maximal voluntary contraction (MVC) or maximal electrical nerve stimulation. As MVC may be unreliable and maximal electrical stimulation too painful, we assessed if hyperpolarization can also be induced by submaximal electrical nerve stimulation.

METHODS: In 8 healthy volunteers different submaximal electrical stimulus trains were given to the median nerve at the wrist, followed by 5 min assessment of thresholds for compound muscle action potentials of 20%, 40% or 60% of maximal.

RESULTS: Threshold increase after submaximal electrical nerve stimulation was most prominent after an 8 Hz train of at least 5 min duration evoking submaximal CMAPs of 60%. It induced minimal discomfort and was not painful. Threshold increase after MVC was not significantly higher than this stimulus train.

CONCLUSIONS: Submaximal electrical stimulation evokes activity dependent hyperpolarization in healthy test subjects without causing significant discomfort.

SIGNIFICANCE: Sodium-potassium pump function may be assessed using submaximal electrical stimulation.

Original language	English
Pages (from-to)	809-814
Number of pages	6
Journal	Clinical Neurophysiology
Volume	129
Issue number	4
DOIs	https://doi.org/10.1016/j.clinph.2018.01.016
Publication status	Published - Apr 2018

Keywords

Axonal hyperpolarization
Excitability
Pump test
Sodium-potassium pump
Stimulus train
Threshold tracking

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10.1016/j.clinph.2018.01.016

SodiumFinal published version, 833 KBLicence: Taverne

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title = "Sodium-potassium pump assessment by submaximal electrical nerve stimulation",

abstract = "OBJECTIVE: Sodium-potassium pump dysfunction in peripheral nerve is usually assessed by determining axonal hyperpolarization following maximal voluntary contraction (MVC) or maximal electrical nerve stimulation. As MVC may be unreliable and maximal electrical stimulation too painful, we assessed if hyperpolarization can also be induced by submaximal electrical nerve stimulation.METHODS: In 8 healthy volunteers different submaximal electrical stimulus trains were given to the median nerve at the wrist, followed by 5 min assessment of thresholds for compound muscle action potentials of 20\%, 40\% or 60\% of maximal.RESULTS: Threshold increase after submaximal electrical nerve stimulation was most prominent after an 8 Hz train of at least 5 min duration evoking submaximal CMAPs of 60\%. It induced minimal discomfort and was not painful. Threshold increase after MVC was not significantly higher than this stimulus train.CONCLUSIONS: Submaximal electrical stimulation evokes activity dependent hyperpolarization in healthy test subjects without causing significant discomfort.SIGNIFICANCE: Sodium-potassium pump function may be assessed using submaximal electrical stimulation.",

keywords = "Axonal hyperpolarization, Excitability, Pump test, Sodium-potassium pump, Stimulus train, Threshold tracking",

author = "Steven Hageman and Kovalchuk, \{Maria O\} and Sleutjes, \{Boudewijn T H M\} and \{van Schelven\}, \{Leonard J\} and \{van den Berg\}, \{Leonard H\} and Hessel Franssen",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = apr,

doi = "10.1016/j.clinph.2018.01.016",

language = "English",

volume = "129",

pages = "809--814",

journal = "Clinical Neurophysiology",

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T1 - Sodium-potassium pump assessment by submaximal electrical nerve stimulation

AU - Hageman, Steven

AU - Kovalchuk, Maria O

AU - Sleutjes, Boudewijn T H M

AU - van Schelven, Leonard J

AU - van den Berg, Leonard H

AU - Franssen, Hessel

PY - 2018/4

Y1 - 2018/4

N2 - OBJECTIVE: Sodium-potassium pump dysfunction in peripheral nerve is usually assessed by determining axonal hyperpolarization following maximal voluntary contraction (MVC) or maximal electrical nerve stimulation. As MVC may be unreliable and maximal electrical stimulation too painful, we assessed if hyperpolarization can also be induced by submaximal electrical nerve stimulation.METHODS: In 8 healthy volunteers different submaximal electrical stimulus trains were given to the median nerve at the wrist, followed by 5 min assessment of thresholds for compound muscle action potentials of 20%, 40% or 60% of maximal.RESULTS: Threshold increase after submaximal electrical nerve stimulation was most prominent after an 8 Hz train of at least 5 min duration evoking submaximal CMAPs of 60%. It induced minimal discomfort and was not painful. Threshold increase after MVC was not significantly higher than this stimulus train.CONCLUSIONS: Submaximal electrical stimulation evokes activity dependent hyperpolarization in healthy test subjects without causing significant discomfort.SIGNIFICANCE: Sodium-potassium pump function may be assessed using submaximal electrical stimulation.

AB - OBJECTIVE: Sodium-potassium pump dysfunction in peripheral nerve is usually assessed by determining axonal hyperpolarization following maximal voluntary contraction (MVC) or maximal electrical nerve stimulation. As MVC may be unreliable and maximal electrical stimulation too painful, we assessed if hyperpolarization can also be induced by submaximal electrical nerve stimulation.METHODS: In 8 healthy volunteers different submaximal electrical stimulus trains were given to the median nerve at the wrist, followed by 5 min assessment of thresholds for compound muscle action potentials of 20%, 40% or 60% of maximal.RESULTS: Threshold increase after submaximal electrical nerve stimulation was most prominent after an 8 Hz train of at least 5 min duration evoking submaximal CMAPs of 60%. It induced minimal discomfort and was not painful. Threshold increase after MVC was not significantly higher than this stimulus train.CONCLUSIONS: Submaximal electrical stimulation evokes activity dependent hyperpolarization in healthy test subjects without causing significant discomfort.SIGNIFICANCE: Sodium-potassium pump function may be assessed using submaximal electrical stimulation.

KW - Axonal hyperpolarization

KW - Excitability

KW - Pump test

KW - Sodium-potassium pump

KW - Stimulus train

KW - Threshold tracking

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U2 - 10.1016/j.clinph.2018.01.016

DO - 10.1016/j.clinph.2018.01.016

M3 - Article

C2 - 29477980

SN - 1388-2457

VL - 129

SP - 809

EP - 814

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 4

ER -

Sodium-potassium pump assessment by submaximal electrical nerve stimulation

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Keywords

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