Sodium intake affects urinary albumin excretion especially in overweight subjects

J. C. Verhave; H. L. Hillege; J. G.M. Burgerhof; W. M.T. Janssen; R. T. Gansevoort; G. J. Navis; D. De Zeeuw; P. E. De Jong; W. H. Van Gilst; R. H. Henning; R.O.B. Gans; S. J.L. Bakker; A. J. Smit; A. M. Van Roon; E. M. Stuveling; D. J. Van Veldhuisen; A. J. Van Boven; F. W. Asselbergs; C. P. Baljé-Volkers; R. P.F. Dullaart; G. J. Te Meerman; G. T. Spijker; V. Fidler; L. T.W. De Jong-Van Den Berg; M. J. Postma; J. Van Den Berg; J. H.J. Muntinga; D. E. Grobbee

doi:10.1111/j.1365-2796.2004.01390.x

Sodium intake affects urinary albumin excretion especially in overweight subjects

J. C. Verhave, H. L. Hillege, J. G.M. Burgerhof, W. M.T. Janssen, R. T. Gansevoort, G. J. Navis, D. De Zeeuw, P. E. De Jong^*, W. H. Van Gilst, R. H. Henning, R.O.B. Gans, S. J.L. Bakker, A. J. Smit, A. M. Van Roon, E. M. Stuveling, D. J. Van Veldhuisen, A. J. Van Boven, F. W. Asselbergs, C. P. Baljé-Volkers, R. P.F. DullaartG. J. Te Meerman, G. T. Spijker, V. Fidler, L. T.W. De Jong-Van Den Berg, M. J. Postma, J. Van Den Berg, J. H.J. Muntinga, D. E. Grobbee

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objectives. To examine the relationship between sodium intake and urinary albumin excretion, being an established risk marker for later cardiovascular morbidity and mortality. Design. Cross-sectional cohort study using linear regression analysis. Setting. University hospital outpatient clinic. Subjects. A cohort drawn from the general population, consisting of 7850 subjects 28-75 years of age, all inhabitants of the city of Groningen, the Netherlands. The cohort is enriched for the presence of subjects with elevated urinary albumin concentration. Results. The results show a positive relationship between dietary sodium intake and urinary albumin excretion. The association was independent of other cardiovascular risk factors (such as sex, age, blood pressure, body mass index (BMI), waist-to-hip ratio, serum cholesterol, plasma glucose and smoking) and other food constituents (calcium, potassium and protein). The relationship between sodium intake and urinary albumin excretion was steeper in subjects with a higher BMI compared with a lower BMI. Conclusions. Sodium intake is positively related to urinary albumin excretion. This relation is more pronounced in subjects with a higher BMI. These results suggest that high sodium intake may unfavourably influences cardiovascular prognosis especially in overweight and obese subjects.

Original language	English
Pages (from-to)	324-330
Number of pages	7
Journal	Journal of Internal Medicine
Volume	256
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2796.2004.01390.x
Publication status	Published - 1 Oct 2004

Keywords

Cardiovascular risk factor
Microalbuminuria
Obesity
Urinary sodium excretion

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Verhave, J. C., Hillege, H. L., Burgerhof, J. G. M., Janssen, W. M. T., Gansevoort, R. T., Navis, G. J., De Zeeuw, D., De Jong, P. E., Van Gilst, W. H., Henning, R. H., Gans, R. O. B., Bakker, S. J. L., Smit, A. J., Van Roon, A. M., Stuveling, E. M., Van Veldhuisen, D. J., Van Boven, A. J., Asselbergs, F. W., Baljé-Volkers, C. P., ... Grobbee, D. E. (2004). Sodium intake affects urinary albumin excretion especially in overweight subjects. Journal of Internal Medicine, 256(4), 324-330. https://doi.org/10.1111/j.1365-2796.2004.01390.x

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title = "Sodium intake affects urinary albumin excretion especially in overweight subjects",

abstract = "Objectives. To examine the relationship between sodium intake and urinary albumin excretion, being an established risk marker for later cardiovascular morbidity and mortality. Design. Cross-sectional cohort study using linear regression analysis. Setting. University hospital outpatient clinic. Subjects. A cohort drawn from the general population, consisting of 7850 subjects 28-75 years of age, all inhabitants of the city of Groningen, the Netherlands. The cohort is enriched for the presence of subjects with elevated urinary albumin concentration. Results. The results show a positive relationship between dietary sodium intake and urinary albumin excretion. The association was independent of other cardiovascular risk factors (such as sex, age, blood pressure, body mass index (BMI), waist-to-hip ratio, serum cholesterol, plasma glucose and smoking) and other food constituents (calcium, potassium and protein). The relationship between sodium intake and urinary albumin excretion was steeper in subjects with a higher BMI compared with a lower BMI. Conclusions. Sodium intake is positively related to urinary albumin excretion. This relation is more pronounced in subjects with a higher BMI. These results suggest that high sodium intake may unfavourably influences cardiovascular prognosis especially in overweight and obese subjects.",

keywords = "Cardiovascular risk factor, Microalbuminuria, Obesity, Urinary sodium excretion",

author = "Verhave, {J. C.} and Hillege, {H. L.} and Burgerhof, {J. G.M.} and Janssen, {W. M.T.} and Gansevoort, {R. T.} and Navis, {G. J.} and {De Zeeuw}, D. and {De Jong}, {P. E.} and {Van Gilst}, {W. H.} and Henning, {R. H.} and R.O.B. Gans and Bakker, {S. J.L.} and Smit, {A. J.} and {Van Roon}, {A. M.} and Stuveling, {E. M.} and {Van Veldhuisen}, {D. J.} and {Van Boven}, {A. J.} and Asselbergs, {F. W.} and Balj{\'e}-Volkers, {C. P.} and Dullaart, {R. P.F.} and {Te Meerman}, {G. J.} and Spijker, {G. T.} and V. Fidler and {De Jong-Van Den Berg}, {L. T.W.} and Postma, {M. J.} and {Van Den Berg}, J. and Muntinga, {J. H.J.} and Grobbee, {D. E.}",

year = "2004",

month = oct,

day = "1",

doi = "10.1111/j.1365-2796.2004.01390.x",

language = "English",

volume = "256",

pages = "324--330",

journal = "Journal of Internal Medicine",

issn = "0954-6820",

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Verhave, JC, Hillege, HL, Burgerhof, JGM, Janssen, WMT, Gansevoort, RT, Navis, GJ, De Zeeuw, D, De Jong, PE, Van Gilst, WH, Henning, RH, Gans, ROB, Bakker, SJL, Smit, AJ, Van Roon, AM, Stuveling, EM, Van Veldhuisen, DJ, Van Boven, AJ, Asselbergs, FW, Baljé-Volkers, CP, Dullaart, RPF, Te Meerman, GJ, Spijker, GT, Fidler, V, De Jong-Van Den Berg, LTW, Postma, MJ, Van Den Berg, J, Muntinga, JHJ & Grobbee, DE 2004, 'Sodium intake affects urinary albumin excretion especially in overweight subjects', Journal of Internal Medicine, vol. 256, no. 4, pp. 324-330. https://doi.org/10.1111/j.1365-2796.2004.01390.x

TY - JOUR

T1 - Sodium intake affects urinary albumin excretion especially in overweight subjects

AU - Verhave, J. C.

AU - Hillege, H. L.

AU - Burgerhof, J. G.M.

AU - Janssen, W. M.T.

AU - Gansevoort, R. T.

AU - Navis, G. J.

AU - De Zeeuw, D.

AU - De Jong, P. E.

AU - Van Gilst, W. H.

AU - Henning, R. H.

AU - Gans, R.O.B.

AU - Bakker, S. J.L.

AU - Smit, A. J.

AU - Van Roon, A. M.

AU - Stuveling, E. M.

AU - Van Veldhuisen, D. J.

AU - Van Boven, A. J.

AU - Asselbergs, F. W.

AU - Baljé-Volkers, C. P.

AU - Dullaart, R. P.F.

AU - Te Meerman, G. J.

AU - Spijker, G. T.

AU - Fidler, V.

AU - De Jong-Van Den Berg, L. T.W.

AU - Postma, M. J.

AU - Van Den Berg, J.

AU - Muntinga, J. H.J.

AU - Grobbee, D. E.

PY - 2004/10/1

Y1 - 2004/10/1

N2 - Objectives. To examine the relationship between sodium intake and urinary albumin excretion, being an established risk marker for later cardiovascular morbidity and mortality. Design. Cross-sectional cohort study using linear regression analysis. Setting. University hospital outpatient clinic. Subjects. A cohort drawn from the general population, consisting of 7850 subjects 28-75 years of age, all inhabitants of the city of Groningen, the Netherlands. The cohort is enriched for the presence of subjects with elevated urinary albumin concentration. Results. The results show a positive relationship between dietary sodium intake and urinary albumin excretion. The association was independent of other cardiovascular risk factors (such as sex, age, blood pressure, body mass index (BMI), waist-to-hip ratio, serum cholesterol, plasma glucose and smoking) and other food constituents (calcium, potassium and protein). The relationship between sodium intake and urinary albumin excretion was steeper in subjects with a higher BMI compared with a lower BMI. Conclusions. Sodium intake is positively related to urinary albumin excretion. This relation is more pronounced in subjects with a higher BMI. These results suggest that high sodium intake may unfavourably influences cardiovascular prognosis especially in overweight and obese subjects.

AB - Objectives. To examine the relationship between sodium intake and urinary albumin excretion, being an established risk marker for later cardiovascular morbidity and mortality. Design. Cross-sectional cohort study using linear regression analysis. Setting. University hospital outpatient clinic. Subjects. A cohort drawn from the general population, consisting of 7850 subjects 28-75 years of age, all inhabitants of the city of Groningen, the Netherlands. The cohort is enriched for the presence of subjects with elevated urinary albumin concentration. Results. The results show a positive relationship between dietary sodium intake and urinary albumin excretion. The association was independent of other cardiovascular risk factors (such as sex, age, blood pressure, body mass index (BMI), waist-to-hip ratio, serum cholesterol, plasma glucose and smoking) and other food constituents (calcium, potassium and protein). The relationship between sodium intake and urinary albumin excretion was steeper in subjects with a higher BMI compared with a lower BMI. Conclusions. Sodium intake is positively related to urinary albumin excretion. This relation is more pronounced in subjects with a higher BMI. These results suggest that high sodium intake may unfavourably influences cardiovascular prognosis especially in overweight and obese subjects.

KW - Cardiovascular risk factor

KW - Microalbuminuria

KW - Obesity

KW - Urinary sodium excretion

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U2 - 10.1111/j.1365-2796.2004.01390.x

DO - 10.1111/j.1365-2796.2004.01390.x

M3 - Article

C2 - 15367175

AN - SCOPUS:4644300219

SN - 0954-6820

VL - 256

SP - 324

EP - 330

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

IS - 4

ER -

Sodium intake affects urinary albumin excretion especially in overweight subjects

Abstract

Keywords

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