Socioeconomic Inequalities in the External Exposome in European Cohorts: The EXPANSE Project

Apolline Saucy; Fabián Coloma; Sergio Olmos; Christofer Åström; Natalia Blay; Jolanda M. A. Boer; Payam Dadvand; Jeroen de Bont; Rafael de Cid; Kees de Hoogh; Konstantina Dimakopoulou; Ulrike Gehring; Anke Huss; Dorina Ibi; Klea Katsouyanni; Gerard Koppelman; Petter Ljungman; Erik Melén; Mark Nieuwenhuijsen; Federica Nobile; Annette Peters; Regina Pickford; Roel Vermeulen; Danielle Vienneau; Jelle Vlaanderen; Kathrin Wolf; Zhebin Yu; Evangelia Samoli; Massimo Stafoggia; Cathryn Tonne

doi:10.1021/acs.est.4c01509

Socioeconomic Inequalities in the External Exposome in European Cohorts: The EXPANSE Project

Apolline Saucy^*, Fabián Coloma, Sergio Olmos, Christofer Åström, Natalia Blay, Jolanda M. A. Boer, Payam Dadvand, Jeroen de Bont, Rafael de Cid, Kees de Hoogh, Konstantina Dimakopoulou, Ulrike Gehring, Anke Huss, Dorina Ibi, Klea Katsouyanni, Gerard Koppelman, Petter Ljungman, Erik Melén, Mark Nieuwenhuijsen, Federica NobileAnnette Peters, Regina Pickford, Roel Vermeulen, Danielle Vienneau, Jelle Vlaanderen, Kathrin Wolf, Zhebin Yu, Evangelia Samoli, Massimo Stafoggia, Cathryn Tonne

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Socioeconomic inequalities in the exposome have been found to be complex and highly context-specific, but studies have not been conducted in large population-wide cohorts from multiple countries. This study aims to examine the external exposome, encompassing individual and environmental factors influencing health over the life course, and to perform dimension reduction to derive interpretable characterization of the external exposome for multicountry epidemiological studies. Analyzing data from over 25 million individuals across seven European countries including 12 administrative and traditional cohorts, we utilized domain-specific principal component analysis (PCA) to define the external exposome, focusing on air pollution, the built environment, and air temperature. We conducted linear regression to estimate the association between individual- and area-level socioeconomic position and each domain of the external exposome. Consistent exposure patterns were observed within countries, indicating the representativeness of traditional cohorts for air pollution and the built environment. However, cohorts with limited geographical coverage and Southern European countries displayed lower temperature variability, especially in the cold season, compared to Northern European countries and cohorts including a wide range of urban and rural areas. The individual- and area-level socioeconomic determinants (i.e., education, income, and unemployment rate) of the urban exposome exhibited significant variability across the European region, with area-level indicators showing stronger associations than individual variables. While the PCA approach facilitated common interpretations of the external exposome for air pollution and the built environment, it was less effective for air temperature. The diverse socioeconomic determinants suggest regional variations in environmental health inequities, emphasizing the need for targeted interventions across European countries.

Original language	English
Pages (from-to)	16248-16257
Number of pages	10
Journal	Environmental Science and Technology
Volume	58
Issue number	37
DOIs	https://doi.org/10.1021/acs.est.4c01509
Publication status	Published - 17 Sept 2024
Externally published	Yes

Keywords

European cohorts
environmental health equity
external exposome
socioeconomic determinants

Access to Document

10.1021/acs.est.4c01509Licence: CC BY

Cite this

Saucy, A., Coloma, F., Olmos, S., Åström, C., Blay, N., Boer, J. M. A., Dadvand, P., de Bont, J., de Cid, R., de Hoogh, K., Dimakopoulou, K., Gehring, U., Huss, A., Ibi, D., Katsouyanni, K., Koppelman, G., Ljungman, P., Melén, E., Nieuwenhuijsen, M., ... Tonne, C. (2024). Socioeconomic Inequalities in the External Exposome in European Cohorts: The EXPANSE Project. Environmental Science and Technology, 58(37), 16248-16257. https://doi.org/10.1021/acs.est.4c01509

@article{59d54cfb16a24caaae3d55be971e6312,

title = "Socioeconomic Inequalities in the External Exposome in European Cohorts: The EXPANSE Project",

abstract = "Socioeconomic inequalities in the exposome have been found to be complex and highly context-specific, but studies have not been conducted in large population-wide cohorts from multiple countries. This study aims to examine the external exposome, encompassing individual and environmental factors influencing health over the life course, and to perform dimension reduction to derive interpretable characterization of the external exposome for multicountry epidemiological studies. Analyzing data from over 25 million individuals across seven European countries including 12 administrative and traditional cohorts, we utilized domain-specific principal component analysis (PCA) to define the external exposome, focusing on air pollution, the built environment, and air temperature. We conducted linear regression to estimate the association between individual- and area-level socioeconomic position and each domain of the external exposome. Consistent exposure patterns were observed within countries, indicating the representativeness of traditional cohorts for air pollution and the built environment. However, cohorts with limited geographical coverage and Southern European countries displayed lower temperature variability, especially in the cold season, compared to Northern European countries and cohorts including a wide range of urban and rural areas. The individual- and area-level socioeconomic determinants (i.e., education, income, and unemployment rate) of the urban exposome exhibited significant variability across the European region, with area-level indicators showing stronger associations than individual variables. While the PCA approach facilitated common interpretations of the external exposome for air pollution and the built environment, it was less effective for air temperature. The diverse socioeconomic determinants suggest regional variations in environmental health inequities, emphasizing the need for targeted interventions across European countries.",

keywords = "European cohorts, environmental health equity, external exposome, socioeconomic determinants",

author = "Apolline Saucy and Fabi{\'a}n Coloma and Sergio Olmos and Christofer {\AA}str{\"o}m and Natalia Blay and Boer, {Jolanda M. A.} and Payam Dadvand and {de Bont}, Jeroen and {de Cid}, Rafael and {de Hoogh}, Kees and Konstantina Dimakopoulou and Ulrike Gehring and Anke Huss and Dorina Ibi and Klea Katsouyanni and Gerard Koppelman and Petter Ljungman and Erik Mel{\'e}n and Mark Nieuwenhuijsen and Federica Nobile and Annette Peters and Regina Pickford and Roel Vermeulen and Danielle Vienneau and Jelle Vlaanderen and Kathrin Wolf and Zhebin Yu and Evangelia Samoli and Massimo Stafoggia and Cathryn Tonne",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Published by American Chemical Society.",

year = "2024",

month = sep,

day = "17",

doi = "10.1021/acs.est.4c01509",

language = "English",

volume = "58",

pages = "16248--16257",

journal = "Environmental Science and Technology",

issn = "0013-936X",

publisher = "American Chemical Society",

number = "37",

}

Saucy, A, Coloma, F, Olmos, S, Åström, C, Blay, N, Boer, JMA, Dadvand, P, de Bont, J, de Cid, R, de Hoogh, K, Dimakopoulou, K, Gehring, U, Huss, A, Ibi, D, Katsouyanni, K, Koppelman, G, Ljungman, P, Melén, E, Nieuwenhuijsen, M, Nobile, F, Peters, A, Pickford, R, Vermeulen, R , Vienneau, D, Vlaanderen, J, Wolf, K, Yu, Z, Samoli, E, Stafoggia, M & Tonne, C 2024, 'Socioeconomic Inequalities in the External Exposome in European Cohorts: The EXPANSE Project', Environmental Science and Technology, vol. 58, no. 37, pp. 16248-16257. https://doi.org/10.1021/acs.est.4c01509

TY - JOUR

T1 - Socioeconomic Inequalities in the External Exposome in European Cohorts: The EXPANSE Project

AU - Saucy, Apolline

AU - Coloma, Fabián

AU - Olmos, Sergio

AU - Åström, Christofer

AU - Blay, Natalia

AU - Boer, Jolanda M. A.

AU - Dadvand, Payam

AU - de Bont, Jeroen

AU - de Cid, Rafael

AU - de Hoogh, Kees

AU - Dimakopoulou, Konstantina

AU - Gehring, Ulrike

AU - Huss, Anke

AU - Ibi, Dorina

AU - Katsouyanni, Klea

AU - Koppelman, Gerard

AU - Ljungman, Petter

AU - Melén, Erik

AU - Nieuwenhuijsen, Mark

AU - Nobile, Federica

AU - Peters, Annette

AU - Pickford, Regina

AU - Vermeulen, Roel

AU - Vienneau, Danielle

AU - Vlaanderen, Jelle

AU - Wolf, Kathrin

AU - Yu, Zhebin

AU - Samoli, Evangelia

AU - Stafoggia, Massimo

AU - Tonne, Cathryn

PY - 2024/9/17

Y1 - 2024/9/17

N2 - Socioeconomic inequalities in the exposome have been found to be complex and highly context-specific, but studies have not been conducted in large population-wide cohorts from multiple countries. This study aims to examine the external exposome, encompassing individual and environmental factors influencing health over the life course, and to perform dimension reduction to derive interpretable characterization of the external exposome for multicountry epidemiological studies. Analyzing data from over 25 million individuals across seven European countries including 12 administrative and traditional cohorts, we utilized domain-specific principal component analysis (PCA) to define the external exposome, focusing on air pollution, the built environment, and air temperature. We conducted linear regression to estimate the association between individual- and area-level socioeconomic position and each domain of the external exposome. Consistent exposure patterns were observed within countries, indicating the representativeness of traditional cohorts for air pollution and the built environment. However, cohorts with limited geographical coverage and Southern European countries displayed lower temperature variability, especially in the cold season, compared to Northern European countries and cohorts including a wide range of urban and rural areas. The individual- and area-level socioeconomic determinants (i.e., education, income, and unemployment rate) of the urban exposome exhibited significant variability across the European region, with area-level indicators showing stronger associations than individual variables. While the PCA approach facilitated common interpretations of the external exposome for air pollution and the built environment, it was less effective for air temperature. The diverse socioeconomic determinants suggest regional variations in environmental health inequities, emphasizing the need for targeted interventions across European countries.

AB - Socioeconomic inequalities in the exposome have been found to be complex and highly context-specific, but studies have not been conducted in large population-wide cohorts from multiple countries. This study aims to examine the external exposome, encompassing individual and environmental factors influencing health over the life course, and to perform dimension reduction to derive interpretable characterization of the external exposome for multicountry epidemiological studies. Analyzing data from over 25 million individuals across seven European countries including 12 administrative and traditional cohorts, we utilized domain-specific principal component analysis (PCA) to define the external exposome, focusing on air pollution, the built environment, and air temperature. We conducted linear regression to estimate the association between individual- and area-level socioeconomic position and each domain of the external exposome. Consistent exposure patterns were observed within countries, indicating the representativeness of traditional cohorts for air pollution and the built environment. However, cohorts with limited geographical coverage and Southern European countries displayed lower temperature variability, especially in the cold season, compared to Northern European countries and cohorts including a wide range of urban and rural areas. The individual- and area-level socioeconomic determinants (i.e., education, income, and unemployment rate) of the urban exposome exhibited significant variability across the European region, with area-level indicators showing stronger associations than individual variables. While the PCA approach facilitated common interpretations of the external exposome for air pollution and the built environment, it was less effective for air temperature. The diverse socioeconomic determinants suggest regional variations in environmental health inequities, emphasizing the need for targeted interventions across European countries.

KW - European cohorts

KW - environmental health equity

KW - external exposome

KW - socioeconomic determinants

U2 - 10.1021/acs.est.4c01509

DO - 10.1021/acs.est.4c01509

M3 - Article

SN - 0013-936X

VL - 58

SP - 16248

EP - 16257

JO - Environmental Science and Technology

JF - Environmental Science and Technology

IS - 37

ER -

Socioeconomic Inequalities in the External Exposome in European Cohorts: The EXPANSE Project

Abstract

Keywords

Access to Document

Fingerprint

Cite this