TY - JOUR
T1 - Smokers and non-smokers with rheumatoid arthritis have similar clinical status
T2 - Data from the multinational QUEST-RA database
AU - Naranjo, A.
AU - Toloza, S.
AU - Guimaraes Da Silveira, I.
AU - Lazovskis, J.
AU - Hetland, M. L.
AU - Hamoud, H.
AU - Peets, T.
AU - Mäkinen, H.
AU - Gossec, L.
AU - Herborn, G.
AU - Skopouli, F. N.
AU - Rojkovich, B.
AU - Aggarwal, A.
AU - Minnock, P.
AU - Cazzato, M.
AU - Yamanaka, H.
AU - Oyoo, O.
AU - Rexhepi, S.
AU - Andersone, D.
AU - Baranauskaite, A.
AU - Hajjaj-Hassouni, N.
AU - Jacobs, J. W.G.
AU - Haugeberg, G.
AU - Sierakowski, S.
AU - Ionescu, R.
AU - Karateew, D.
AU - Dimic, A.
AU - Henrohn, D.
AU - Gogus, F.
AU - Badsha, H.
AU - Choy, E.
AU - Bergman, M.
AU - Sokka, T.
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Objectives To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status. Methods The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RF), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as "never smoked", "currently smoking" and "former smokers". Patient groups with different smoking status were compared for demographic and RA measures. Results Among the 7,307patients with smoking data available, status as "never smoked," "current smoker" and "former smoker" were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32;1.17-1.48, p<0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41 ;1.24-1.59, p<0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category). Conclusion RA patients who had ever smoked were more likely to have RF and nodules, but values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).
AB - Objectives To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status. Methods The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RF), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as "never smoked", "currently smoking" and "former smokers". Patient groups with different smoking status were compared for demographic and RA measures. Results Among the 7,307patients with smoking data available, status as "never smoked," "current smoker" and "former smoker" were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32;1.17-1.48, p<0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41 ;1.24-1.59, p<0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category). Conclusion RA patients who had ever smoked were more likely to have RF and nodules, but values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).
KW - DAS
KW - HAQ
KW - Rheumatoid arthritis
KW - Smoking
UR - http://www.scopus.com/inward/record.url?scp=79952632750&partnerID=8YFLogxK
M3 - Article
C2 - 21205460
AN - SCOPUS:79952632750
SN - 0392-856X
VL - 28
SP - 820
EP - 827
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
IS - 6
ER -