Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

Mark W. Logue; Sanne J H van Rooij; Emily L. Dennis; Sarah L. Davis; Jasmeet P. Hayes; Jennifer S. Stevens; Maria Densmore; Courtney C. Haswell; Jonathan Ipser; Saskia B.J. Koch; Mayuresh Korgaonkar; Lauren A.M. Lebois; Matthew Peverill; Justin T. Baker; Premika S W Boedhoe; Jessie L. Frijling; Staci A. Gruber; Ilan Harpaz-Rotem; Neda Jahanshad; Sheri Koopowitz; Ifat Levy; Laura Nawijn; Lauren O'Connor; Miranda Olff; David H. Salat; Margaret A. Sheridan; Jeffrey M. Spielberg; Mirjam van Zuiden; Sherry R. Winternitz; Jonathan D. Wolff; Erika J. Wolf; Xin Wang; Kristen Wrocklage; Chadi G. Abdallah; Richard A. Bryant; Elbert Geuze; Tanja Jovanovic; Milissa L. Kaufman; Anthony P. King; John H. Krystal; Jim Lagopoulos; Maxwell Bennett; Ruth Lanius; Israel Liberzon; Regina E. McGlinchey; Katie A. McLaughlin; William P. Milberg; Mark W. Miller; Kerry J Ressler; Dick J. Veltman; Dan J Stein; Kathleen Thomaes; Paul M. Thompson; Rajendra A. Morey

doi:10.1016/j.biopsych.2017.09.006

Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

Mark W. Logue, Sanne J H van Rooij, Emily L. Dennis, Sarah L. Davis, Jasmeet P. Hayes, Jennifer S. Stevens, Maria Densmore, Courtney C. Haswell, Jonathan Ipser, Saskia B.J. Koch, Mayuresh Korgaonkar, Lauren A.M. Lebois, Matthew Peverill, Justin T. Baker, Premika S W Boedhoe, Jessie L. Frijling, Staci A. Gruber, Ilan Harpaz-Rotem, Neda Jahanshad, Sheri KoopowitzIfat Levy, Laura Nawijn, Lauren O'Connor, Miranda Olff, David H. Salat, Margaret A. Sheridan, Jeffrey M. Spielberg, Mirjam van Zuiden, Sherry R. Winternitz, Jonathan D. Wolff, Erika J. Wolf, Xin Wang, Kristen Wrocklage, Chadi G. Abdallah, Richard A. Bryant, Elbert Geuze, Tanja Jovanovic, Milissa L. Kaufman, Anthony P. King, John H. Krystal, Jim Lagopoulos, Maxwell Bennett, Ruth Lanius, Israel Liberzon, Regina E. McGlinchey, Katie A. McLaughlin, William P. Milberg, Mark W. Miller, Kerry J Ressler, Dick J. Veltman, Dan J Stein, Kathleen Thomaes, Paul M. Thompson, Rajendra A. Morey^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

Original language	English
Pages (from-to)	244-253
Number of pages	10
Journal	Biological Psychiatry
Volume	83
Issue number	3
DOIs	https://doi.org/10.1016/j.biopsych.2017.09.006
Publication status	Published - 1 Feb 2018

Keywords

Amygdala
Childhood trauma
Gender differences
Hippocampus
PTSD
Structural MRI

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10.1016/j.biopsych.2017.09.006

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Logue, M. W., van Rooij, S. J. H., Dennis, E. L., Davis, S. L., Hayes, J. P., Stevens, J. S., Densmore, M., Haswell, C. C., Ipser, J., Koch, S. B. J., Korgaonkar, M., Lebois, L. A. M., Peverill, M., Baker, J. T., Boedhoe, P. S. W., Frijling, J. L., Gruber, S. A., Harpaz-Rotem, I., Jahanshad, N., ... Morey, R. A. (2018). Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. Biological Psychiatry, 83(3), 244-253. https://doi.org/10.1016/j.biopsych.2017.09.006

@article{64ac579c7e984f228bfa11838a5f1418,

title = "Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia",

abstract = "Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.",

keywords = "Amygdala, Childhood trauma, Gender differences, Hippocampus, PTSD, Structural MRI",

author = "Logue, {Mark W.} and {van Rooij}, {Sanne J H} and Dennis, {Emily L.} and Davis, {Sarah L.} and Hayes, {Jasmeet P.} and Stevens, {Jennifer S.} and Maria Densmore and Haswell, {Courtney C.} and Jonathan Ipser and Koch, {Saskia B.J.} and Mayuresh Korgaonkar and Lebois, {Lauren A.M.} and Matthew Peverill and Baker, {Justin T.} and Boedhoe, {Premika S W} and Frijling, {Jessie L.} and Gruber, {Staci A.} and Ilan Harpaz-Rotem and Neda Jahanshad and Sheri Koopowitz and Ifat Levy and Laura Nawijn and Lauren O'Connor and Miranda Olff and Salat, {David H.} and Sheridan, {Margaret A.} and Spielberg, {Jeffrey M.} and {van Zuiden}, Mirjam and Winternitz, {Sherry R.} and Wolff, {Jonathan D.} and Wolf, {Erika J.} and Xin Wang and Kristen Wrocklage and Abdallah, {Chadi G.} and Bryant, {Richard A.} and Elbert Geuze and Tanja Jovanovic and Kaufman, {Milissa L.} and King, {Anthony P.} and Krystal, {John H.} and Jim Lagopoulos and Maxwell Bennett and Ruth Lanius and Israel Liberzon and McGlinchey, {Regina E.} and McLaughlin, {Katie A.} and Milberg, {William P.} and Miller, {Mark W.} and Ressler, {Kerry J} and Veltman, {Dick J.} and Stein, {Dan J} and Kathleen Thomaes and Thompson, {Paul M.} and Morey, {Rajendra A.}",

note = "Funding Information: This work was supported by the Netherlands Organization for Health Research and Development ZonMw Grant Nos. 40-00812-98-10041 (to MO) and 100-020-002 (to KT); Academic Medical Center Research Council File No. 110614 (to MO); MRC Unit on Anxiety & Stress Disorders (to DJS); Bill and Melinda Gates Foundation Grant No. OPP 1017641 (to DJS); Department of Defense Grant No. W81XWH-12-2-0012 (to PMT); National Institute for Mental Health Grant No. R01-MH111671-01 and VISN6 MIRECC (to RAM); VA Merit Grant Nos. 1I01RX000389-01 (to RAM) and 1I01CX000748-01A1 (to RAM); National Institute of Neurological Disorders and Stroke Grant Nos. 5R01NS086885-02 and K23 MH073091-01 (to RAM); National Institute of Mental Health Grant Nos. MH071537 (to KJR), MH098212 (to TJ), F32 MH101976 (to JSS), R21MH112956-01 (to KJR), R21MH102834 (to MWM), K01-MH092526 (to KAM), and R01-MH103291 (to KAM); National Center for Research Resources Grant No. M01RR00039 (to KJR); National Center for Advancing Translational Sciences Grant No. UL1TR000454 (to JSS); Anonymous Women{\textquoteright}s Health Fund McLean Hospital (to MLK); Frazier Foundation Grant for Mood and Anxiety Research McLean Hospital (to MLK); O{\textquoteright}Keefe Family Foundation, Trauma Scholars Fund McLean Hospital (to MLK); National Health and Medical Research Council Grant No. 1073041 (to RAB), VA Biomedical Laboratory Research and Development Grant No. I01BX003477 (to MWL); Traumatic Brain Injury National Network Research Center Grant No. B9254-C (to REM and WPM); Child Health Research Award (to KAM); Charles H. Hood Foundation (to KAM); Young Investigator Grant, Brain and Behavior Foundation (to KAM); Telecommunication and Advanced Technology Research Center Grant No. W81XWH-08-2-0208 (to APK); Center for Computation in Medicine and Biology (to APK); Dutch Ministry of Defence (to EG); VA National Center for PTSD (to KW, CGA, and JHK); Canadian Institutes of Health Research (to MD); and Canadian Institute for Military and Veteran Health Research (to MD and RL). Publisher Copyright: {\textcopyright} 2017",

year = "2018",

month = feb,

day = "1",

doi = "10.1016/j.biopsych.2017.09.006",

language = "English",

volume = "83",

pages = "244--253",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier",

number = "3",

}

Logue, MW, van Rooij, SJH, Dennis, EL, Davis, SL, Hayes, JP, Stevens, JS, Densmore, M, Haswell, CC, Ipser, J, Koch, SBJ, Korgaonkar, M, Lebois, LAM, Peverill, M, Baker, JT, Boedhoe, PSW, Frijling, JL, Gruber, SA, Harpaz-Rotem, I, Jahanshad, N, Koopowitz, S, Levy, I, Nawijn, L, O'Connor, L, Olff, M, Salat, DH, Sheridan, MA, Spielberg, JM, van Zuiden, M, Winternitz, SR, Wolff, JD, Wolf, EJ, Wang, X, Wrocklage, K, Abdallah, CG, Bryant, RA, Geuze, E, Jovanovic, T, Kaufman, ML, King, AP, Krystal, JH, Lagopoulos, J, Bennett, M, Lanius, R, Liberzon, I, McGlinchey, RE, McLaughlin, KA, Milberg, WP, Miller, MW, Ressler, KJ, Veltman, DJ, Stein, DJ, Thomaes, K, Thompson, PM & Morey, RA 2018, 'Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia', Biological Psychiatry, vol. 83, no. 3, pp. 244-253. https://doi.org/10.1016/j.biopsych.2017.09.006

Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. / Logue, Mark W.; van Rooij, Sanne J H; Dennis, Emily L. et al.
In: Biological Psychiatry, Vol. 83, No. 3, 01.02.2018, p. 244-253.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Smaller Hippocampal Volume in Posttraumatic Stress Disorder

T2 - A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

AU - Logue, Mark W.

AU - van Rooij, Sanne J H

AU - Dennis, Emily L.

AU - Davis, Sarah L.

AU - Hayes, Jasmeet P.

AU - Stevens, Jennifer S.

AU - Densmore, Maria

AU - Haswell, Courtney C.

AU - Ipser, Jonathan

AU - Koch, Saskia B.J.

AU - Korgaonkar, Mayuresh

AU - Lebois, Lauren A.M.

AU - Peverill, Matthew

AU - Baker, Justin T.

AU - Boedhoe, Premika S W

AU - Frijling, Jessie L.

AU - Gruber, Staci A.

AU - Harpaz-Rotem, Ilan

AU - Jahanshad, Neda

AU - Koopowitz, Sheri

AU - Levy, Ifat

AU - Nawijn, Laura

AU - O'Connor, Lauren

AU - Olff, Miranda

AU - Salat, David H.

AU - Sheridan, Margaret A.

AU - Spielberg, Jeffrey M.

AU - van Zuiden, Mirjam

AU - Winternitz, Sherry R.

AU - Wolff, Jonathan D.

AU - Wolf, Erika J.

AU - Wang, Xin

AU - Wrocklage, Kristen

AU - Abdallah, Chadi G.

AU - Bryant, Richard A.

AU - Geuze, Elbert

AU - Jovanovic, Tanja

AU - Kaufman, Milissa L.

AU - King, Anthony P.

AU - Krystal, John H.

AU - Lagopoulos, Jim

AU - Bennett, Maxwell

AU - Lanius, Ruth

AU - Liberzon, Israel

AU - McGlinchey, Regina E.

AU - McLaughlin, Katie A.

AU - Milberg, William P.

AU - Miller, Mark W.

AU - Ressler, Kerry J

AU - Veltman, Dick J.

AU - Stein, Dan J

AU - Thomaes, Kathleen

AU - Thompson, Paul M.

AU - Morey, Rajendra A.

N1 - Funding Information: This work was supported by the Netherlands Organization for Health Research and Development ZonMw Grant Nos. 40-00812-98-10041 (to MO) and 100-020-002 (to KT); Academic Medical Center Research Council File No. 110614 (to MO); MRC Unit on Anxiety & Stress Disorders (to DJS); Bill and Melinda Gates Foundation Grant No. OPP 1017641 (to DJS); Department of Defense Grant No. W81XWH-12-2-0012 (to PMT); National Institute for Mental Health Grant No. R01-MH111671-01 and VISN6 MIRECC (to RAM); VA Merit Grant Nos. 1I01RX000389-01 (to RAM) and 1I01CX000748-01A1 (to RAM); National Institute of Neurological Disorders and Stroke Grant Nos. 5R01NS086885-02 and K23 MH073091-01 (to RAM); National Institute of Mental Health Grant Nos. MH071537 (to KJR), MH098212 (to TJ), F32 MH101976 (to JSS), R21MH112956-01 (to KJR), R21MH102834 (to MWM), K01-MH092526 (to KAM), and R01-MH103291 (to KAM); National Center for Research Resources Grant No. M01RR00039 (to KJR); National Center for Advancing Translational Sciences Grant No. UL1TR000454 (to JSS); Anonymous Women’s Health Fund McLean Hospital (to MLK); Frazier Foundation Grant for Mood and Anxiety Research McLean Hospital (to MLK); O’Keefe Family Foundation, Trauma Scholars Fund McLean Hospital (to MLK); National Health and Medical Research Council Grant No. 1073041 (to RAB), VA Biomedical Laboratory Research and Development Grant No. I01BX003477 (to MWL); Traumatic Brain Injury National Network Research Center Grant No. B9254-C (to REM and WPM); Child Health Research Award (to KAM); Charles H. Hood Foundation (to KAM); Young Investigator Grant, Brain and Behavior Foundation (to KAM); Telecommunication and Advanced Technology Research Center Grant No. W81XWH-08-2-0208 (to APK); Center for Computation in Medicine and Biology (to APK); Dutch Ministry of Defence (to EG); VA National Center for PTSD (to KW, CGA, and JHK); Canadian Institutes of Health Research (to MD); and Canadian Institute for Military and Veteran Health Research (to MD and RL). Publisher Copyright: © 2017

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

AB - Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

KW - Amygdala

KW - Childhood trauma

KW - Gender differences

KW - Hippocampus

KW - PTSD

KW - Structural MRI

UR - http://www.scopus.com/inward/record.url?scp=85034845116&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2017.09.006

DO - 10.1016/j.biopsych.2017.09.006

M3 - Article

AN - SCOPUS:85034845116

SN - 0006-3223

VL - 83

SP - 244

EP - 253

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 3

ER -

Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

Abstract

Keywords

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