@article{9dab3ca2cc0b4431b5144c72ce5841a3,
title = "Small vessel disease lesion type and brain atrophy: The role of co-occurring amyloid",
abstract = "Introduction: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co-occurring Alzheimer's disease pathology affects this relation.Methods: In 725 memory clinic patients with SVD (mean age 67 ± 8 years, 48% female) we compared brain volumes of those with moderate/severe white matter hyperintensities (WMHs; n = 326), lacunes (n = 132) and cerebral microbleeds (n = 321) to a reference group with mild WMHs (n = 197), also considering cerebrospinal fluid (CSF) amyloid status in a subset of patients (n = 488).Results: WMHs and lacunes, but not cerebral microbleeds, were associated with smaller gray matter (GM) volumes. In analyses stratified by CSF amyloid status, WMHs and lacunes were associated with smaller total brain and GM volumes only in amyloid-negative patients. SVD-related atrophy was most evident in frontal (cortical) GM, again predominantly in amyloid-negative patients.Discussion: Amyloid status modifies the differential relation between SVD lesion type and brain atrophy in memory clinic patients.",
keywords = "Alzheimer's disease, brain atrophy, cerebral microbleeds, cerebral small vessel disease, lacunes, magnetic resonance imaging, vascular cognitive impairment, white matter hyperintensities",
author = "Rutger Heinen and Groeneveld, {Onno N} and Frederik Barkhof and {de Bresser}, Jeroen and Exalto, {Lieza G} and Kuijf, {Hugo J} and Prins, {Niels D} and Philip Scheltens and {van der Flier}, {Wiesje M} and Biessels, {Geert Jan}",
note = "Funding Information: The TRACE-VCI study is supported by Vidi grant 91711384 and Vici grant 91816616 from ZonMw, the Netherlands, Organisation for Health Research to Geert Jan Biessels and Development and grant 2010T073 from the Dutch Heart Foundation to Geert Jan Biessels. Research of the Amsterdam UMC Alzheimer Center is part of the neurodegeneration research program of the Neuroscience Campus Amsterdam. The Amsterdam UMC Alzheimer Center is supported by Stichting Alzheimer Nederland and Stichting VUMC fonds. FB is supported by the NIHR UCLH biomedical research center. Members of the TRACE-VCI study group (in alphabetical order, per department): University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands: 1) Department of Neurology: E. van den Berg, G.J. Biessels, J.M.F. Boomsma, L.G. Exalto, D.A. Ferro, C.J.M. Frijns, O.N. Groeneveld, R. Heinen, N.M. van Kalsbeek, J.H. Verwer; 2) Department of Radiology: J. de Bresser; 3) Image Sciences Institute: H.J. Kuijf; 4) Department of Geriatrics: M.E. Emmelot-Vonk, H.L. Koek. Amsterdam UMC, Amsterdam, the Netherlands: 1) Alzheimer Center and Department of Neurology: M.R. Benedictus, J. Bremer, W.M. van der Flier, A.E. Leeuwis, J. Leijenaar, N.D. Prins, P. Scheltens, B.M. Tijms; 2) Department of Radiology and Nuclear Medicine: F. Barkhof, M.P. Wattjes; 3) Department of Clinical Chemistry: C.E. Teunissen; 4) Department of Medical Psychology: T. Koene. Onze Lieve Vrouwe Gasthuis West, Amsterdam, the Netherlands: 1) Department of Neurology: J.M.F. Boomsma, H.C. Weinstein. Hospital Diakonessenhuis, Zeist, the Netherlands: M. Hamaker, R. Faaij, M. Pleizier, M. Prins, E. Vriens. Funding Information: The TRACE‐VCI study is supported by Vidi grant 91711384 and Vici grant 91816616 from ZonMw, the Netherlands, Organisation for Health Research to Geert Jan Biessels and Development and grant 2010T073 from the Dutch Heart Foundation to Geert Jan Biessels. Research of the Amsterdam UMC Alzheimer Center is part of the neurodegeneration research program of the Neuroscience Campus Amsterdam. The Amsterdam UMC Alzheimer Center is supported by Stichting Alzheimer Nederland and Stichting VUMC fonds. FB is supported by the NIHR UCLH biomedical research center. Publisher Copyright: {\textcopyright} 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2020",
doi = "10.1002/dad2.12060",
language = "English",
volume = "12",
pages = "1--11",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "John Wiley & Sons Inc.",
number = "1",
}