TY - JOUR
T1 - Sleep quality trajectories from head and neck cancer diagnosis to six months after treatment
AU - Santoso, Angelina M M
AU - Jansen, Femke
AU - Lissenberg-Witte, Birgit I
AU - Baatenburg de Jong, Robert J
AU - Langendijk, Johannes A
AU - Leemans, C René
AU - Smit, Johannes H
AU - Takes, Robert P
AU - Terhaard, Chris H J
AU - van Straten, Annemieke
AU - Verdonck-de Leeuw, Irma M
N1 - Funding Information:
Funding: This study was carried out using the research infrastructure within the NETherlands Quality of life and Biomedical Cohort study in head and neck cancer (NET-QUBIC) project funded by the Dutch Cancer Society / Alpe d'Huzes (grant number VU-2013?5930). The funding body had no role in the study design, the data collection, analysis, and interpretation, nor the manuscript preparation.
Funding Information:
Funding: This study was carried out using the research infrastructure within the NETherlands Quality of life and Biomedical Cohort study in head and neck cancer (NET-QUBIC) project funded by the Dutch Cancer Society / Alpe d’Huzes (grant number VU-2013–5930 ). The funding body had no role in the study design, the data collection, analysis, and interpretation, nor the manuscript preparation.
Publisher Copyright:
© 2021 The Authors
PY - 2021/4
Y1 - 2021/4
N2 - OBJECTIVES: Patients with head and neck cancer (HNC) often report disturbances in their sleep quality, impairing their quality of life. This study aims to examine the trajectories of sleep quality from diagnosis up to 6-month after treatment, as well as the pre-treatment risk factors for poor sleep trajectories.MATERIALS AND METHODS: Sleep quality (Pittsburgh sleep quality index) was measured shortly after diagnosis (pre-treatment), and at 3 and 6 months after finishing treatment. Patients were categorized into 5 trajectory groups. We examined the association of sleep quality trajectories with sociodemographic and clinical characteristics, coping style, HNC symptoms, and psychological distress.RESULTS: Among 412 included patients, about a half either had a persistent good sleep (37.6%) or an improving (16.5%) trajectory. About a third had a persistent poor sleep (21.8%) or worsening (10.9%) sleep trajectory. The remaining patients (13.1%), alternated between good and poor sleep. Using persistent good sleep as a reference outcome, persistent poor sleepers were more likely to be woman (odds ratio [OR] = 1.98, 95% confidence interval [CI] 1.01-3.90), use painkillers prior to treatment (OR = 2.52, 95% CI 1.33-4.77), and have more pre-treatment anxiety symptoms (OR = 1.26, 95% CI 1.15-1.38).CONCLUSION: Unfavorable sleep quality trajectories are prevalent among HNC patients from pre-treatment to 6-month after treatment. A periodic sleep evaluation starting shortly after HNC diagnosis is necessary to identify persistent sleep problems, especially among high-risk group.
AB - OBJECTIVES: Patients with head and neck cancer (HNC) often report disturbances in their sleep quality, impairing their quality of life. This study aims to examine the trajectories of sleep quality from diagnosis up to 6-month after treatment, as well as the pre-treatment risk factors for poor sleep trajectories.MATERIALS AND METHODS: Sleep quality (Pittsburgh sleep quality index) was measured shortly after diagnosis (pre-treatment), and at 3 and 6 months after finishing treatment. Patients were categorized into 5 trajectory groups. We examined the association of sleep quality trajectories with sociodemographic and clinical characteristics, coping style, HNC symptoms, and psychological distress.RESULTS: Among 412 included patients, about a half either had a persistent good sleep (37.6%) or an improving (16.5%) trajectory. About a third had a persistent poor sleep (21.8%) or worsening (10.9%) sleep trajectory. The remaining patients (13.1%), alternated between good and poor sleep. Using persistent good sleep as a reference outcome, persistent poor sleepers were more likely to be woman (odds ratio [OR] = 1.98, 95% confidence interval [CI] 1.01-3.90), use painkillers prior to treatment (OR = 2.52, 95% CI 1.33-4.77), and have more pre-treatment anxiety symptoms (OR = 1.26, 95% CI 1.15-1.38).CONCLUSION: Unfavorable sleep quality trajectories are prevalent among HNC patients from pre-treatment to 6-month after treatment. A periodic sleep evaluation starting shortly after HNC diagnosis is necessary to identify persistent sleep problems, especially among high-risk group.
KW - Head and neck cancer
KW - Sleep quality
KW - Trajectory
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85100625676&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2021.105211
DO - 10.1016/j.oraloncology.2021.105211
M3 - Article
C2 - 33581506
SN - 1368-8375
VL - 115
JO - Oral Oncology
JF - Oral Oncology
M1 - 105211
ER -