@inproceedings{b01a0a26067540c586488004b2fa72cd,
title = "Silicon Central Pattern Generator Model of Cardiac Contraction Behavior",
abstract = "Synchronization of brain cells underlies the generation of key motor functions including breathing, cardiac activity and locomotion. The circuitry mechanisms underpinning this phase-locked rhythmic patterns have been studied in local circuitry networks known as Central Pattern Generators (CPGs). Biological CPGs (bCPGs) in healthy nervous systems demonstrate robustness and adaptation in response to variations in sensory feedback. This study aims at constructing biologically-plausible network models of analog hardware CPGs (hCPGs), and assimilating the membrane voltages of all constituting neurons in the network with large-scale constrained nonlinear optimization. The hCPG model exhibits a tetra-phasic behavior where the spike timings of the four neurons corresponds to the activation of the heart chambers: sino-atrial node, left atrium, left ventricle and right ventricle. We show the results of modelling electrocardiogram (ECG) recordings from anesthetized dogs. This research will facilitate designing bioelectronic implants to recover cardiac function in heart diseases. ",
keywords = "Heart, Synapses, Data models, Adaptation models, Biological system modeling",
author = "Abu-Hassan, {Kamal J.} and Taylor, {Joseph D.} and {Van Bavel}, {Joanne J.A.} and Vos, {Marc A.} and Alain Nogaret",
note = "Funding Information: * This work was supported by the European Union's Horizon 2020 Future Emerging Technologies Programme under Grant No. 732170. Publisher Copyright: {\textcopyright} 2020 IEEE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; 11th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2020 ; Conference date: 15-07-2020",
year = "2020",
month = jul,
doi = "10.1109/ESGCO49734.2020.9158033",
language = "English",
series = "2020 11th Conference of the European Study Group on Cardiovascular Oscillations: Computation and Modelling in Physiology: New Challenges and Opportunities, ESGCO 2020",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "2020 11th Conference of the European Study Group on Cardiovascular Oscillations",
address = "United States",
}