Signaling switches: Metabolism regulates gastruloid self-organization

María J Rodríguez Colman; Katharina F Sonnen

doi:10.1016/j.stem.2025.04.005

Signaling switches: Metabolism regulates gastruloid self-organization

María J Rodríguez Colman^*
, Katharina F Sonnen^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

Metabolic regulation of embryonic development is increasingly recognized. Villaronga-Luque et al.1 and Stopornwongkul et al.2 show that metabolic activity influences gastruloid formation from mouse embryonic stem cells, revealing that the balance between glycolysis and oxidative phosphorylation regulates cell fate decisions during gastruloid self-organization.

Original language	English
Pages (from-to)	673-675
Number of pages	3
Journal	Cell stem cell
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2025.04.005
Publication status	Published - 1 May 2025

Keywords

Animals
Glycolysis
Mice
Mouse Embryonic Stem Cells/metabolism
Organoids/metabolism
Oxidative Phosphorylation
Signal Transduction

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10.1016/j.stem.2025.04.005

PIIS1934590925001407Final published version, 1.47 MBLicence: Taverne

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title = "Signaling switches: Metabolism regulates gastruloid self-organization",

abstract = "Metabolic regulation of embryonic development is increasingly recognized. Villaronga-Luque et al.1 and Stopornwongkul et al.2 show that metabolic activity influences gastruloid formation from mouse embryonic stem cells, revealing that the balance between glycolysis and oxidative phosphorylation regulates cell fate decisions during gastruloid self-organization.",

keywords = "Animals, Glycolysis, Mice, Mouse Embryonic Stem Cells/metabolism, Organoids/metabolism, Oxidative Phosphorylation, Signal Transduction",

author = "\{Rodr{\'i}guez Colman\}, \{Mar{\'i}a J\} and Sonnen, \{Katharina F\}",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

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doi = "10.1016/j.stem.2025.04.005",

language = "English",

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TY - JOUR

T1 - Signaling switches

T2 - Metabolism regulates gastruloid self-organization

AU - Rodríguez Colman, María J

AU - Sonnen, Katharina F

PY - 2025/5/1

Y1 - 2025/5/1

N2 - Metabolic regulation of embryonic development is increasingly recognized. Villaronga-Luque et al.1 and Stopornwongkul et al.2 show that metabolic activity influences gastruloid formation from mouse embryonic stem cells, revealing that the balance between glycolysis and oxidative phosphorylation regulates cell fate decisions during gastruloid self-organization.

AB - Metabolic regulation of embryonic development is increasingly recognized. Villaronga-Luque et al.1 and Stopornwongkul et al.2 show that metabolic activity influences gastruloid formation from mouse embryonic stem cells, revealing that the balance between glycolysis and oxidative phosphorylation regulates cell fate decisions during gastruloid self-organization.

KW - Animals

KW - Glycolysis

KW - Mice

KW - Mouse Embryonic Stem Cells/metabolism

KW - Organoids/metabolism

KW - Oxidative Phosphorylation

KW - Signal Transduction

UR - https://www.scopus.com/pages/publications/105003645890

U2 - 10.1016/j.stem.2025.04.005

DO - 10.1016/j.stem.2025.04.005

M3 - Comment/Letter to the editor

C2 - 40315829

SN - 1934-5909

VL - 32

SP - 673

EP - 675

JO - Cell stem cell

JF - Cell stem cell

IS - 5

ER -

Signaling switches: Metabolism regulates gastruloid self-organization

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Keywords

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