Sickle cell patients are characterized by a reduced glycocalyx volume

Edward J. Van Beers; Max Nieuwdrop; Ashley J. Duits; Ludo M. Evers; John-John B. Schnog; Bart J. Biemond

doi:10.3324/haematol.12027

Sickle cell patients are characterized by a reduced glycocalyx volume

Edward J. Van Beers^*, Max Nieuwdrop, Ashley J. Duits, Ludo M. Evers, John-John B. Schnog, Bart J. Biemond,

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Academic › peer-review

Abstract

The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbS beta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbS beta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1x10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.

Original language	English
Pages (from-to)	307-308
Number of pages	2
Journal	Haematologica
Volume	93
Issue number	2
DOIs	https://doi.org/10.3324/haematol.12027
Publication status	Published - Feb 2008
Externally published	Yes

Keywords

ENDOTHELIAL GLYCOCALYX
DYSFUNCTION
COINCIDES
ADHESION
DISEASE

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10.3324/haematol.12027

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title = "Sickle cell patients are characterized by a reduced glycocalyx volume",

abstract = "The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbS beta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbS beta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1x10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.",

keywords = "ENDOTHELIAL GLYCOCALYX, DYSFUNCTION, COINCIDES, ADHESION, DISEASE",

author = "{Van Beers}, {Edward J.} and Max Nieuwdrop and Duits, {Ashley J.} and Evers, {Ludo M.} and Schnog, {John-John B.} and Biemond, {Bart J.}",

year = "2008",

month = feb,

doi = "10.3324/haematol.12027",

language = "English",

volume = "93",

pages = "307--308",

journal = "Haematologica",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

number = "2",

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TY - JOUR

T1 - Sickle cell patients are characterized by a reduced glycocalyx volume

AU - Van Beers, Edward J.

AU - Nieuwdrop, Max

AU - Duits, Ashley J.

AU - Evers, Ludo M.

AU - Schnog, John-John B.

AU - Biemond, Bart J.

PY - 2008/2

Y1 - 2008/2

N2 - The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbS beta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbS beta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1x10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.

AB - The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbS beta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbS beta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1x10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.

KW - ENDOTHELIAL GLYCOCALYX

KW - DYSFUNCTION

KW - COINCIDES

KW - ADHESION

KW - DISEASE

U2 - 10.3324/haematol.12027

DO - 10.3324/haematol.12027

M3 - Letter

C2 - 18245656

SN - 0390-6078

VL - 93

SP - 307

EP - 308

JO - Haematologica

JF - Haematologica

IS - 2

ER -

Sickle cell patients are characterized by a reduced glycocalyx volume

Abstract

Keywords

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