TY - JOUR
T1 - Should the 14-day rule for embryo research become the 28-day rule?
AU - Appleby, John B.
AU - Bredenoord, Annelien L.
N1 - Publisher Copyright:
© 2018 The Authors. Published under the terms of the CC BY 4.0 license
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - The “14-day rule”—broadly construed—is used in science policy and regulation to limit research on human embryos to a maximum period of 14 days after their creation or to the equivalent stage of development that is normally attributed to a 14-day-old embryo (Hyun et al,; Nuffield Council on Bioethics,). For several decades, the 14-day rule has been a shining example of how science policy and regulation can be developed with interdisciplinary consensus and applied across a number of countries to help fulfil an ethical and practical purpose: to facilitate efficient and ethical embryo research. However, advances in embryology and biomedical research have led to suggestions that the 14-day rule is no longer adequate (Deglincerti et al,; Shahbazi et al,; Hurlbut et al,). Therefore, should the 14-day rule be extended and, if so, where should we draw a new line for permissible embryo research? Here, we provide scientific, regulatory and ethical arguments that the 14-day rule should be extended to 28 days (or the developmental equivalent stage of a 28-day-old embryo).
AB - The “14-day rule”—broadly construed—is used in science policy and regulation to limit research on human embryos to a maximum period of 14 days after their creation or to the equivalent stage of development that is normally attributed to a 14-day-old embryo (Hyun et al,; Nuffield Council on Bioethics,). For several decades, the 14-day rule has been a shining example of how science policy and regulation can be developed with interdisciplinary consensus and applied across a number of countries to help fulfil an ethical and practical purpose: to facilitate efficient and ethical embryo research. However, advances in embryology and biomedical research have led to suggestions that the 14-day rule is no longer adequate (Deglincerti et al,; Shahbazi et al,; Hurlbut et al,). Therefore, should the 14-day rule be extended and, if so, where should we draw a new line for permissible embryo research? Here, we provide scientific, regulatory and ethical arguments that the 14-day rule should be extended to 28 days (or the developmental equivalent stage of a 28-day-old embryo).
UR - http://www.scopus.com/inward/record.url?scp=85052987803&partnerID=8YFLogxK
U2 - 10.15252/emmm.201809437
DO - 10.15252/emmm.201809437
M3 - Comment/Letter to the editor
AN - SCOPUS:85052987803
SN - 1757-4676
VL - 10
JO - Embo Molecular Medicine
JF - Embo Molecular Medicine
IS - 9
M1 - e9437
ER -