TY - JOUR
T1 - Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders
AU - de Lange, Siemon C.
AU - Scholtens, Lianne H.
AU - van den Berg, Leonard H.
AU - Boks, Marco P.
AU - Bozzali, Marco
AU - Cahn, Wiepke
AU - Dannlowski, Udo
AU - Durston, Sarah
AU - Geuze, Elbert
AU - van Haren, Neeltje E.M.
AU - Hillegers, Manon H.J.
AU - Koch, Kathrin
AU - Jurado, María Ángeles
AU - Mancini, Matteo
AU - Marqués-Iturria, Idoia
AU - Meinert, Susanne
AU - Ophoff, Roel A.
AU - Reess, Tim J.
AU - Repple, Jonathan
AU - Kahn, René S.
AU - van den Heuvel, Martijn P.
N1 - Funding Information:
L.H.v.d.B. serves on scientific advisory boards for Orion, Biogen and Cytokinetics; received an educational grant from Baxalta; serves on the editorial boards of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration and the Journal of Neurology, Neurosurgery, and Psychiatry; and receives research support from the Prinses Beatrix Spierfonds, the Netherlands ALS Foundation, The European Community’s Health Seventh Framework Programme (grant agreement no. 259867) and The Netherlands Organization for Health Research and Development (Vici Scheme, JPND (SOPHIA, STRENGTH, ALSCare)). All other authors declare no competing interests.
Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2019/9
Y1 - 2019/9
N2 - Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain’s connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study comprising in total 1,033 patients and 1,154 matched controls across 8 psychiatric and 4 neurological disorders. We extracted disorder connectome fingerprints for each of these 12 disorders and combined them into a ‘cross-disorder disconnectivity involvement map’ describing the level of cross-disorder involvement of each white matter pathway of the human brain network. Network analysis revealed connections central to global network communication and integration to display high disturbance across disorders, suggesting a general cross-disorder involvement and the importance of these pathways in normal function.
AB - Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain’s connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study comprising in total 1,033 patients and 1,154 matched controls across 8 psychiatric and 4 neurological disorders. We extracted disorder connectome fingerprints for each of these 12 disorders and combined them into a ‘cross-disorder disconnectivity involvement map’ describing the level of cross-disorder involvement of each white matter pathway of the human brain network. Network analysis revealed connections central to global network communication and integration to display high disturbance across disorders, suggesting a general cross-disorder involvement and the importance of these pathways in normal function.
UR - http://www.scopus.com/inward/record.url?scp=85070236674&partnerID=8YFLogxK
U2 - 10.1038/s41562-019-0659-6
DO - 10.1038/s41562-019-0659-6
M3 - Article
C2 - 31384023
AN - SCOPUS:85070236674
SN - 2397-3374
VL - 3
SP - 988
EP - 998
JO - NATURE HUMAN BEHAVIOUR
JF - NATURE HUMAN BEHAVIOUR
IS - 9
ER -