TY - JOUR
T1 - Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe
T2 - Results From the BiomarCaRE Consortium
AU - Magnussen, Christina
AU - Niiranen, Teemu J.
AU - Ojeda, Francisco M.
AU - Gianfagna, Francesco
AU - Blankenberg, Stefan
AU - Vartiainen, Erkki
AU - Sans, Susana
AU - Pasterkamp, Gerard
AU - Hughes, Maria
AU - Costanzo, Simona
AU - Donati, Maria Benedetta
AU - Jousilahti, Pekka
AU - Linneberg, Allan
AU - Palosaari, Tarja
AU - de Gaetano, Giovanni
AU - Bobak, Martin
AU - den Ruijter, Hester M.
AU - Jørgensen, Torben
AU - Söderberg, Stefan
AU - Kuulasmaa, Kari
AU - Zeller, Tanja
AU - Iacoviello, Licia
AU - Salomaa, Veikko
AU - Schnabel, Renate B.
N1 - Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
PY - 2019/3
Y1 - 2019/3
N2 - OBJECTIVES: This study investigates differences between women and men in heart failure (HF) risk and mortality.BACKGROUND: Sex differences in HF epidemiology are insufficiently understood.METHODS: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro-B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men.RESULTS: Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9%]) than in men (n = 2,771 [7.3%]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (HR) according to SD in women of 1.09 (95% confidence interval [CI]: 1.05 to 1.14) versus HR of 1.19 (95% CI: 1.14 to 1.24) in men; heart rate HR of 0.98 (95% CI: 0.93 to 1.03) in women versus HR of 1.09 (95% CI: 1.04 to 1.13) in men; CRP HR of 1.10 (95% CI: 1.00 to 1.20) in women versus HR of 1.32 (95% CI: 1.24 to 1.41) in men; and NT-proBNP HR of 1.54 (95% CI: 1.37 to 1.74) in women versus HR of 1.89 (95% CI: 1.75 to 2.05) in men. Population-attributable risk of all risk factors combined was 59.0% in women and 62.9% in men.CONCLUSIONS: Women had a lower risk for HF than men. Sex differences were seen for systolic blood pressure, heart rate, CRP, and NT-proBNP, with a lower HF risk in women.
AB - OBJECTIVES: This study investigates differences between women and men in heart failure (HF) risk and mortality.BACKGROUND: Sex differences in HF epidemiology are insufficiently understood.METHODS: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro-B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men.RESULTS: Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9%]) than in men (n = 2,771 [7.3%]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (HR) according to SD in women of 1.09 (95% confidence interval [CI]: 1.05 to 1.14) versus HR of 1.19 (95% CI: 1.14 to 1.24) in men; heart rate HR of 0.98 (95% CI: 0.93 to 1.03) in women versus HR of 1.09 (95% CI: 1.04 to 1.13) in men; CRP HR of 1.10 (95% CI: 1.00 to 1.20) in women versus HR of 1.32 (95% CI: 1.24 to 1.41) in men; and NT-proBNP HR of 1.54 (95% CI: 1.37 to 1.74) in women versus HR of 1.89 (95% CI: 1.75 to 2.05) in men. Population-attributable risk of all risk factors combined was 59.0% in women and 62.9% in men.CONCLUSIONS: Women had a lower risk for HF than men. Sex differences were seen for systolic blood pressure, heart rate, CRP, and NT-proBNP, with a lower HF risk in women.
KW - biomarkers
KW - cohort
KW - epidemiology
KW - heart failure
KW - mortality
KW - sex
UR - http://www.scopus.com/inward/record.url?scp=85061563131&partnerID=8YFLogxK
U2 - 10.1016/j.jchf.2018.08.008
DO - 10.1016/j.jchf.2018.08.008
M3 - Article
C2 - 30819375
SN - 2213-1779
VL - 7
SP - 204
EP - 213
JO - JACC. Heart failure
JF - JACC. Heart failure
IS - 3
ER -