@article{22af7ef3417142f59b3c43994ae446e4,
title = "Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group",
abstract = "Males and females with alcohol dependence have distinct mental health and cognitive problems. Animal models of addiction postulate that the underlying neurobiological mechanisms are partially distinct, but there is little evidence of sex differences in humans with alcohol dependence as most neuroimaging studies have been conducted in males. We examined hippocampal and amygdala subregions in a large sample of 966 people from the ENIGMA Addiction Working Group. This comprised 643 people with alcohol dependence (225 females), and a comparison group of 323 people without alcohol dependence (98 females). Males with alcohol dependence had smaller volumes of the total amygdala and its basolateral nucleus than male controls, that exacerbated with alcohol dose. Alcohol dependence was also associated with smaller volumes of the hippocampus and its CA1 and subiculum subfield volumes in both males and females. In summary, hippocampal and amygdalar subregions may be sensitive to both shared and distinct mechanisms in alcohol-dependent males and females.",
keywords = "Alcoholism, Amygdala, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Neuroanatomy, Sex Characteristics",
author = "Sally Grace and Rossetti, {Maria Gloria} and Nicholas Allen and Albert Batalla and Marcella Bellani and Paolo Brambilla and Yann Chye and Janna Cousijn and Goudriaan, {Anna E.} and Robert Hester and Kent Hutchison and Izelle Labuschagne and Reza Momenan and Rocio Martin-Santos and Peter Rendell and Nadia Solowij and Rajita Sinha and Li, {Chiang shan Ray} and Lianne Schmaal and Zsuzsika Sjoerds and Chao Suo and Gill Terrett and {van Holst}, {Ruth J.} and Veltman, {Dick J.} and Murat Y{\"u}cel and Paul Thompson and Patricia Conrod and Scott Mackey and Hugh Garavan and Valentina Lorenzetti",
note = "Funding Information: Paul Thomson received grant support from Biogen, Inc., for work unrelated to this manuscript. Funding Information: We thank Diny Thomson, Danielle Tichelaar, Emily Robinson, Emily Watt, Iris Starcheus, Jamie Gladwell, John Tzaferis, Kirsty Kearney, and Simone Mizzi for their significant contributions to the image quality checks. We thank Preveetha Patalay for her helpful contributions to the statistical modelling; Philip Saemann for providing comments on code to generate the images for visual inspection; and Juan Dominguez for his helpful comments on the code to perform the FreeSurfer segmentation. This work was supported by the MASSIVE HPC facility (www.massive.org.au). This work was also supported by funding from the U.S. National Institute of Health (NIH R01DA047119) and the U.S. National Institute of Mental Health (NIH/NIMH R01MH116147). Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = mar,
day = "4",
doi = "10.1038/s41398-021-01204-1",
language = "English",
volume = "11",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",
number = "1",
}