Severity of Respiratory Infections With Seasonal Coronavirus Is Associated With Viral and Bacterial Coinfections

Emma M de Koff; Marlies A van Houten; Elisabeth A M Sanders; Debby Bogaert

doi:10.1097/INF.0000000000002940

Severity of Respiratory Infections With Seasonal Coronavirus Is Associated With Viral and Bacterial Coinfections

Emma M de Koff, Marlies A van Houten, Elisabeth A M Sanders, Debby Bogaert

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The clinical presentation of human coronavirus (HCoV) infections in children varies strongly. We show that children with an HCoV-associated lower respiratory tract infection more frequently had respiratory syncytial virus codetected and higher abundance of Haemophilus influenzae/haemolyticus than asymptomatic HCoV carriers as well as children with a non-HCoV-associated lower respiratory tract infection. Viral and bacterial cooccurrence may drive symptomatology of HCoV-associated infections including coronavirus disease 2019.

Original language	English
Pages (from-to)	e36-e39
Number of pages	4
Journal	The Pediatric infectious disease journal
Volume	40
Issue number	1
DOIs	https://doi.org/10.1097/INF.0000000000002940
Publication status	Published - Jan 2021

Keywords

SARS-CoV-2
coinfection
coronaviruses
lower respiratory tract infection
pediatrics

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10.1097/INF.0000000000002940

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title = "Severity of Respiratory Infections With Seasonal Coronavirus Is Associated With Viral and Bacterial Coinfections",

abstract = "The clinical presentation of human coronavirus (HCoV) infections in children varies strongly. We show that children with an HCoV-associated lower respiratory tract infection more frequently had respiratory syncytial virus codetected and higher abundance of Haemophilus influenzae/haemolyticus than asymptomatic HCoV carriers as well as children with a non-HCoV-associated lower respiratory tract infection. Viral and bacterial cooccurrence may drive symptomatology of HCoV-associated infections including coronavirus disease 2019.",

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AU - Sanders, Elisabeth A M

AU - Bogaert, Debby

PY - 2021/1

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AB - The clinical presentation of human coronavirus (HCoV) infections in children varies strongly. We show that children with an HCoV-associated lower respiratory tract infection more frequently had respiratory syncytial virus codetected and higher abundance of Haemophilus influenzae/haemolyticus than asymptomatic HCoV carriers as well as children with a non-HCoV-associated lower respiratory tract infection. Viral and bacterial cooccurrence may drive symptomatology of HCoV-associated infections including coronavirus disease 2019.

KW - SARS-CoV-2

KW - coinfection

KW - coronaviruses

KW - lower respiratory tract infection

KW - pediatrics

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JO - The Pediatric infectious disease journal

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ER -

Severity of Respiratory Infections With Seasonal Coronavirus Is Associated With Viral and Bacterial Coinfections

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Keywords

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