Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms

N.M. van Sorge; W.L. van der Pol; M.D. Jansen; KP Geleijns; S. Kalmijn; R.A. Hughes; JH Rees; J Pritchard; CA Vedeler; KM Myhr; C Shaw; I.N. van Schaik; J.H.J. Wokke; P.A. van Doorn; B.C. Jacobs; J.G.J. van de Winkel; L.H. van den Berg

doi:10.1016/j.jneuroim.2005.01.016

Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms

N.M. van Sorge, W.L. van der Pol, M.D. Jansen, KP Geleijns, S. Kalmijn, R.A. Hughes, JH Rees, J Pritchard, CA Vedeler, KM Myhr, C Shaw, I.N. van Schaik, J.H.J. Wokke, P.A. van Doorn, B.C. Jacobs, J.G.J. van de Winkel, L.H. van den Berg

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS.

Original language	English
Pages (from-to)	157-64
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	162
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2005.01.016
Publication status	Published - 2005

Keywords

Adult
Cohort Studies
European Continental Ancestry Group
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Guillain-Barre Syndrome
Humans
Male
Meta-Analysis as Topic
Middle Aged
Polymorphism, Genetic
Receptors, Fc
Retrospective Studies
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.jneuroim.2005.01.016

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van Sorge, N. M., van der Pol, W. L., Jansen, M. D., Geleijns, KP., Kalmijn, S., Hughes, R. A., Rees, JH., Pritchard, J., Vedeler, CA., Myhr, KM., Shaw, C., van Schaik, I. N., Wokke, J. H. J., van Doorn, P. A., Jacobs, B. C., van de Winkel, J. G. J., & van den Berg, L. H. (2005). Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms. Journal of Neuroimmunology, 162(1-2), 157-64. https://doi.org/10.1016/j.jneuroim.2005.01.016

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title = "Severity of Guillain-Barr{\'e} syndrome is associated with Fc gamma Receptor III polymorphisms",

abstract = "Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS.",

keywords = "Adult, Cohort Studies, European Continental Ancestry Group, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Guillain-Barre Syndrome, Humans, Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Genetic, Receptors, Fc, Retrospective Studies, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't",

author = "\{van Sorge\}, N.M. and \{van der Pol\}, W.L. and M.D. Jansen and KP Geleijns and S. Kalmijn and R.A. Hughes and JH Rees and J Pritchard and CA Vedeler and KM Myhr and C Shaw and \{van Schaik\}, I.N. and J.H.J. Wokke and \{van Doorn\}, P.A. and B.C. Jacobs and \{van de Winkel\}, J.G.J. and \{van den Berg\}, L.H.",

year = "2005",

doi = "10.1016/j.jneuroim.2005.01.016",

language = "English",

volume = "162",

pages = "157--64",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

van Sorge, NM, van der Pol, WL, Jansen, MD, Geleijns, KP, Kalmijn, S, Hughes, RA, Rees, JH, Pritchard, J, Vedeler, CA, Myhr, KM, Shaw, C, van Schaik, IN, Wokke, JHJ, van Doorn, PA, Jacobs, BC, van de Winkel, JGJ & van den Berg, LH 2005, 'Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms', Journal of Neuroimmunology, vol. 162, no. 1-2, pp. 157-64. https://doi.org/10.1016/j.jneuroim.2005.01.016

TY - JOUR

T1 - Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms

AU - van Sorge, N.M.

AU - van der Pol, W.L.

AU - Jansen, M.D.

AU - Geleijns, KP

AU - Kalmijn, S.

AU - Hughes, R.A.

AU - Rees, JH

AU - Pritchard, J

AU - Vedeler, CA

AU - Myhr, KM

AU - Shaw, C

AU - van Schaik, I.N.

AU - Wokke, J.H.J.

AU - van Doorn, P.A.

AU - Jacobs, B.C.

AU - van de Winkel, J.G.J.

AU - van den Berg, L.H.

PY - 2005

Y1 - 2005

N2 - Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS.

AB - Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS.

KW - Adult

KW - Cohort Studies

KW - European Continental Ancestry Group

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Guillain-Barre Syndrome

KW - Humans

KW - Male

KW - Meta-Analysis as Topic

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Receptors, Fc

KW - Retrospective Studies

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.jneuroim.2005.01.016

DO - 10.1016/j.jneuroim.2005.01.016

M3 - Article

C2 - 15833371

SN - 0165-5728

VL - 162

SP - 157

EP - 164

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms

Abstract

Keywords

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