Severe hepatitis and pure red cell aplasia in adult Still's disease: good response to immunosuppressive therapy

H L Janssen; J M van Laar; B van Hoek; G J den Ottolander; J H van Krieken; F C Breedveld

Severe hepatitis and pure red cell aplasia in adult Still's disease: good response to immunosuppressive therapy

H L Janssen, J M van Laar, B van Hoek, G J den Ottolander, J H van Krieken, F C Breedveld

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Adult-onset Still's disease is a systemic inflammatory disorder with a highly variable clinical course. Mild hepatitis and anemia are common manifestations. We describe a patient with adult Still's disease who developed a severe hepatitis and a life-threatening pure red cell aplasia. The hepatitis developed after treatment with NSAIDs was started. The patient was successfully treated with a combination of prednisone, cyclosporin, and methotrexate. Physicians should be aware that severe hepatitis and pure red cell aplasia can occur in adult Still's disease. We recommend a careful monitoring of liver functions in patients with adult Still's disease who are being treated with NSAIDs.

Original language	English
Pages (from-to)	1639-42
Number of pages	4
Journal	Digestive Diseases and Sciences
Volume	44
Issue number	8
Publication status	Published - Aug 1999
Externally published	Yes

Keywords

Adult
Anti-Inflammatory Agents
Cyclosporine
Female
Hepatitis
Humans
Immunosuppression
Immunosuppressive Agents
Methotrexate
Prednisone
Red-Cell Aplasia, Pure
Still's Disease, Adult-Onset
Case Reports
Journal Article

Cite this

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title = "Severe hepatitis and pure red cell aplasia in adult Still's disease: good response to immunosuppressive therapy",

abstract = "Adult-onset Still's disease is a systemic inflammatory disorder with a highly variable clinical course. Mild hepatitis and anemia are common manifestations. We describe a patient with adult Still's disease who developed a severe hepatitis and a life-threatening pure red cell aplasia. The hepatitis developed after treatment with NSAIDs was started. The patient was successfully treated with a combination of prednisone, cyclosporin, and methotrexate. Physicians should be aware that severe hepatitis and pure red cell aplasia can occur in adult Still's disease. We recommend a careful monitoring of liver functions in patients with adult Still's disease who are being treated with NSAIDs.",

keywords = "Adult, Anti-Inflammatory Agents, Cyclosporine, Female, Hepatitis, Humans, Immunosuppression, Immunosuppressive Agents, Methotrexate, Prednisone, Red-Cell Aplasia, Pure, Still's Disease, Adult-Onset, Case Reports, Journal Article",

author = "Janssen, {H L} and {van Laar}, {J M} and {van Hoek}, B and {den Ottolander}, {G J} and {van Krieken}, {J H} and Breedveld, {F C}",

year = "1999",

month = aug,

language = "English",

volume = "44",

pages = "1639--42",

journal = "Digestive Diseases and Sciences",

issn = "0163-2116",

publisher = "Springer New York",

number = "8",

}

TY - JOUR

T1 - Severe hepatitis and pure red cell aplasia in adult Still's disease

T2 - good response to immunosuppressive therapy

AU - Janssen, H L

AU - van Laar, J M

AU - van Hoek, B

AU - den Ottolander, G J

AU - van Krieken, J H

AU - Breedveld, F C

PY - 1999/8

Y1 - 1999/8

N2 - Adult-onset Still's disease is a systemic inflammatory disorder with a highly variable clinical course. Mild hepatitis and anemia are common manifestations. We describe a patient with adult Still's disease who developed a severe hepatitis and a life-threatening pure red cell aplasia. The hepatitis developed after treatment with NSAIDs was started. The patient was successfully treated with a combination of prednisone, cyclosporin, and methotrexate. Physicians should be aware that severe hepatitis and pure red cell aplasia can occur in adult Still's disease. We recommend a careful monitoring of liver functions in patients with adult Still's disease who are being treated with NSAIDs.

AB - Adult-onset Still's disease is a systemic inflammatory disorder with a highly variable clinical course. Mild hepatitis and anemia are common manifestations. We describe a patient with adult Still's disease who developed a severe hepatitis and a life-threatening pure red cell aplasia. The hepatitis developed after treatment with NSAIDs was started. The patient was successfully treated with a combination of prednisone, cyclosporin, and methotrexate. Physicians should be aware that severe hepatitis and pure red cell aplasia can occur in adult Still's disease. We recommend a careful monitoring of liver functions in patients with adult Still's disease who are being treated with NSAIDs.

KW - Adult

KW - Anti-Inflammatory Agents

KW - Cyclosporine

KW - Female

KW - Hepatitis

KW - Humans

KW - Immunosuppression

KW - Immunosuppressive Agents

KW - Methotrexate

KW - Prednisone

KW - Red-Cell Aplasia, Pure

KW - Still's Disease, Adult-Onset

KW - Case Reports

KW - Journal Article

M3 - Article

C2 - 10492146

SN - 0163-2116

VL - 44

SP - 1639

EP - 1642

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

IS - 8

ER -

Severe hepatitis and pure red cell aplasia in adult Still's disease: good response to immunosuppressive therapy

Abstract

Keywords

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