Set it free: DNA release from SMC complexes

A.M.O.H.H. Elbatsh

Set it free: DNA release from SMC complexes

A.M.O.H.H. Elbatsh

Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

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Abstract

SMC proteins are major constituents of chromosomes from bacteria to humans. Cohesin
and condensin are members of this family that play central roles in holding together the sister
chromatids and compacting the genome, respectively. Over the past decades the field
has witnessed great progress in understanding the mode of action of these ring-shaped
complexes. We now know that they in essence act as topological devices that execute their
functions by entrapping DNA inside their lumens. It will be key to unravel how these complexes
entrap and release DNA to further dissect the mechanisms through which they control
chromosomes. Here, we discuss the latest findings about cohesin and condensin’s DNA
entrapment and release cycles in light of the results presented in this thesis.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	Medema, René, Primary supervisor Rowland, B.D., Co-supervisor
Award date	13 Dec 2016
Publisher	Utrecht University
Print ISBNs	978-94-6233-467-0
Publication status	Published - 13 Dec 2016

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title = "Set it free: DNA release from SMC complexes",

abstract = "SMC proteins are major constituents of chromosomes from bacteria to humans. Cohesin and condensin are members of this family that play central roles in holding together the sister chromatids and compacting the genome, respectively. Over the past decades the field has witnessed great progress in understanding the mode of action of these ring-shaped complexes. We now know that they in essence act as topological devices that execute their functions by entrapping DNA inside their lumens. It will be key to unravel how these complexes entrap and release DNA to further dissect the mechanisms through which they control chromosomes. Here, we discuss the latest findings about cohesin and condensin{\textquoteright}s DNA entrapment and release cycles in light of the results presented in this thesis.",

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AU - Elbatsh, A.M.O.H.H.

PY - 2016/12/13

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N2 - SMC proteins are major constituents of chromosomes from bacteria to humans. Cohesin and condensin are members of this family that play central roles in holding together the sister chromatids and compacting the genome, respectively. Over the past decades the field has witnessed great progress in understanding the mode of action of these ring-shaped complexes. We now know that they in essence act as topological devices that execute their functions by entrapping DNA inside their lumens. It will be key to unravel how these complexes entrap and release DNA to further dissect the mechanisms through which they control chromosomes. Here, we discuss the latest findings about cohesin and condensin’s DNA entrapment and release cycles in light of the results presented in this thesis.

AB - SMC proteins are major constituents of chromosomes from bacteria to humans. Cohesin and condensin are members of this family that play central roles in holding together the sister chromatids and compacting the genome, respectively. Over the past decades the field has witnessed great progress in understanding the mode of action of these ring-shaped complexes. We now know that they in essence act as topological devices that execute their functions by entrapping DNA inside their lumens. It will be key to unravel how these complexes entrap and release DNA to further dissect the mechanisms through which they control chromosomes. Here, we discuss the latest findings about cohesin and condensin’s DNA entrapment and release cycles in light of the results presented in this thesis.

M3 - Doctoral thesis 2 (Research NOT UU / Graduation UU)

SN - 978-94-6233-467-0

PB - Utrecht University

ER -

Set it free: DNA release from SMC complexes

Abstract

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