TY - JOUR
T1 - Sesame Seed and Its Fractions for Improving Oxidative Stress in Adults
T2 - A Systematic Review and Meta-analysis of Controlled Clinical Trials
AU - Moghtaderi, Fatemeh
AU - Ramezani-Jolfaie, Nahid
AU - Raeisi-Dehkordi, Hamidreza
AU - Salehi-Abargouei, Amin
N1 - Funding Information:
Authors would like to thank the research council of Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences for the financial support of the present study.
Funding Information:
The current study was funded by Nutrition and Food Security research center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Authors would like to thank the research council of Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences for the financial support of the present study.
Publisher Copyright:
© 2019 Taylor & Francis.
PY - 2020/11/16
Y1 - 2020/11/16
N2 - It is proposed that sesame products affect oxidative stress, although the findings were inconsistent. This study aimed to summarize the effect of sesame seed and its fractions on oxidative stress parameters in human adults using systematic review and meta-analysis. PubMed, Scopus, ISI Web of Science and Google Scholar were searched up to April 2018 to identify relevant controlled clinical trials. Random effects model was used for calculating the overall effects. Fifteen clinical trials were eligible. Meta-analyses revealed that sesame consumption significantly increases enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (vitamin C, vitamin E, β-carotene, and glutathione) antioxidants (P < .05). However, no significant effect was observed on malondialdehyde (MDA) (Hedges’ g = −0.80, 95% confidence interval (CI): −1.70, 0.09; P = .078), total antioxidant capacity (WMD = 0.16, 95% CI: −0.19, 0.51; P = .365) and α-tocopherol (WMD = −0.33, 95% CI: −1.11, 0.45; P = .409) levels. It was shown that MDA levels significantly decreases only when sesame seeds were used for supplementation (Hedges’ g = −0.74, 95% CI: −1.11, −0.36, P < .001). Sesame consumption is associated with improved oxidative status. High quality randomized controlled clinical trials from diverse regions are still needed.
AB - It is proposed that sesame products affect oxidative stress, although the findings were inconsistent. This study aimed to summarize the effect of sesame seed and its fractions on oxidative stress parameters in human adults using systematic review and meta-analysis. PubMed, Scopus, ISI Web of Science and Google Scholar were searched up to April 2018 to identify relevant controlled clinical trials. Random effects model was used for calculating the overall effects. Fifteen clinical trials were eligible. Meta-analyses revealed that sesame consumption significantly increases enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (vitamin C, vitamin E, β-carotene, and glutathione) antioxidants (P < .05). However, no significant effect was observed on malondialdehyde (MDA) (Hedges’ g = −0.80, 95% confidence interval (CI): −1.70, 0.09; P = .078), total antioxidant capacity (WMD = 0.16, 95% CI: −0.19, 0.51; P = .365) and α-tocopherol (WMD = −0.33, 95% CI: −1.11, 0.45; P = .409) levels. It was shown that MDA levels significantly decreases only when sesame seeds were used for supplementation (Hedges’ g = −0.74, 95% CI: −1.11, −0.36, P < .001). Sesame consumption is associated with improved oxidative status. High quality randomized controlled clinical trials from diverse regions are still needed.
KW - Meta-analysis
KW - Oxidative stress
KW - Sesame fractions
KW - Sesame seed
KW - Systematic Review
UR - http://www.scopus.com/inward/record.url?scp=85074771324&partnerID=8YFLogxK
U2 - 10.1080/87559129.2019.1683744
DO - 10.1080/87559129.2019.1683744
M3 - Review article
AN - SCOPUS:85074771324
SN - 8755-9129
VL - 36
SP - 727
EP - 744
JO - Food Reviews International
JF - Food Reviews International
IS - 8
ER -