Serum inflammatory mediators correlate with disease activity in electrical status epilepticus in sleep (ESES) syndrome

Bart van den Munckhof; Evelien E de Vries; Kees P J Braun; H Myrthe Boss; Michèl A Willemsen; Annet  van Royen; Wilco de Jager; Floor E Jansen

doi:10.1111/epi.13274

Serum inflammatory mediators correlate with disease activity in electrical status epilepticus in sleep (ESES) syndrome

Bart van den Munckhof
, Evelien E de Vries
, Kees P J Braun
, H Myrthe Boss
, Michèl A Willemsen
, Annet van Royen
, Wilco de Jager
, Floor E Jansen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)-1α, IL-6, IL-10, chemokine (C-C motif) ligand (CCL)2 and chemokine (C-X-C motif) ligand (CXCL)8/IL-8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow-up analyses in five patients revealed a significant decrease of IL-6 levels after immunomodulating treatment. IL-6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL-6 correlates with disease activity and immunomodulating treatment efficacy.

Original language	English
Pages (from-to)	e45–e50
Journal	Epilepsia
Volume	57
Issue number	2
DOIs	https://doi.org/10.1111/epi.13274
Publication status	Published - Feb 2016

Keywords

Cytokines
Electrical status epilepticus during sleep
ESES
Continuous spikes and waves during sleep
CSWS
Landau-Kleffner syndrome

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10.1111/epi.13274

MunckhofFinal published version, 283 KBLicence: Taverne

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title = "Serum inflammatory mediators correlate with disease activity in electrical status epilepticus in sleep (ESES) syndrome",

abstract = "We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)-1α, IL-6, IL-10, chemokine (C-C motif) ligand (CCL)2 and chemokine (C-X-C motif) ligand (CXCL)8/IL-8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow-up analyses in five patients revealed a significant decrease of IL-6 levels after immunomodulating treatment. IL-6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL-6 correlates with disease activity and immunomodulating treatment efficacy.",

keywords = "Cytokines, Electrical status epilepticus during sleep, ESES, Continuous spikes and waves during sleep, CSWS, Landau-Kleffner syndrome",

author = "\{van den Munckhof\}, Bart and \{de Vries\}, \{Evelien E\} and Braun, \{Kees P J\} and Boss, \{H Myrthe\} and Willemsen, \{Mich{\`e}l A\} and \{van Royen\}, Annet and \{de Jager\}, Wilco and Jansen, \{Floor E\}",

note = "Wiley Periodicals, Inc. {\textcopyright} 2015 International League Against Epilepsy.",

year = "2016",

month = feb,

doi = "10.1111/epi.13274",

language = "English",

volume = "57",

pages = " e45–e50",

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T1 - Serum inflammatory mediators correlate with disease activity in electrical status epilepticus in sleep (ESES) syndrome

AU - van den Munckhof, Bart

AU - de Vries, Evelien E

AU - Braun, Kees P J

AU - Boss, H Myrthe

AU - Willemsen, Michèl A

AU - van Royen, Annet

AU - de Jager, Wilco

AU - Jansen, Floor E

PY - 2016/2

Y1 - 2016/2

N2 - We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)-1α, IL-6, IL-10, chemokine (C-C motif) ligand (CCL)2 and chemokine (C-X-C motif) ligand (CXCL)8/IL-8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow-up analyses in five patients revealed a significant decrease of IL-6 levels after immunomodulating treatment. IL-6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL-6 correlates with disease activity and immunomodulating treatment efficacy.

AB - We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)-1α, IL-6, IL-10, chemokine (C-C motif) ligand (CCL)2 and chemokine (C-X-C motif) ligand (CXCL)8/IL-8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow-up analyses in five patients revealed a significant decrease of IL-6 levels after immunomodulating treatment. IL-6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL-6 correlates with disease activity and immunomodulating treatment efficacy.

KW - Cytokines

KW - Electrical status epilepticus during sleep

KW - ESES

KW - Continuous spikes and waves during sleep

KW - CSWS

KW - Landau-Kleffner syndrome

U2 - 10.1111/epi.13274

DO - 10.1111/epi.13274

M3 - Article

C2 - 26666401

SN - 0013-9580

VL - 57

SP - e45–e50

JO - Epilepsia

JF - Epilepsia

IS - 2

ER -

Serum inflammatory mediators correlate with disease activity in electrical status epilepticus in sleep (ESES) syndrome

Abstract

Keywords

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